More Rapid Decline in Kidney Function for Diagnosed Diabetes

Share this content:
More Rapid Decline in Kidney Function for Diagnosed Diabetes
More Rapid Decline in Kidney Function for Diagnosed Diabetes

THURSDAY, June 7, 2018 (HealthDay News) -- Individuals with diagnosed diabetes have more rapid kidney function decline than those without diabetes, according to a study published online June 1 in Diabetes Care.

Bethany Warren, from Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues classified 15,517 participants in the community-based Atherosclerosis Risk in Communities study by diabetes status at baseline. Estimated glomerular filtration rate (eGFR) trajectories were quantified at four visits over 26 years.

The researchers found that over the full study period, the adjusted mean eGFR decline was −1.4 mL/min/1.73 m²/year among participants without diabetes, −1.8 mL/min/1.73 m²/year among those with undiagnosed diabetes, and −2.5 mL/min/1.73 m²/year for those with diagnosed diabetes. Risk factors for steeper eGFR decline among participants with diagnosed diabetes included African-American race, APOL1 high-risk genotype, systolic blood pressure ≥140 mm Hg, insulin use, and higher hemoglobin A1c.

"Among people with diagnosed diabetes, steeper declines were seen in those with modifiable risk factors, including hypertension and glycemic control, suggesting areas for continued targeting in kidney disease prevention," the authors write.

Reagents for the 1,5-anhydroglucitol assays were donated by the GlycoMark Corp.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality ...

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination ...

Pharmacies can address cost barriers to vaccination by providing vaccines at lower cost

Single Blood Sample Test May Help ID Undiagnosed Diabetes

Single Blood Sample Test May Help ID Undiagnosed ...

Single-sample confirmatory definition associated with high positive predictive value

is free, fast, and customized just for you!




Already a member?

Sign In Now »