Modest Links for Systemic Medication Use, IOP in Glaucoma

Share this content:
Modest Links for Systemic Medication Use, IOP in Glaucoma
Modest Links for Systemic Medication Use, IOP in Glaucoma

FRIDAY, Jan. 13, 2017 (HealthDay News) -- Some systemic medication has a modest effect on intraocular pressure (IOP) among Asian patients with glaucoma, according to research published online Jan. 12 in JAMA Ophthalmology.

Henrietta Ho, M.B.B.S., from the Singapore Eye Research Institute, and colleagues conducted a post-hoc analysis to examine the correlation between systemic medication use and IOP in a multiethnic Asian population. Data were analyzed from 8,063 participants from the Singapore Epidemiology of Eye Diseases study with glaucoma from three racial/ethnic groups: Chinese (2,680 participants), Malays (2,757 participants), and Indians (2,626 participants). The correlations between IOP and medications were evaluated in models adjusted for age, sex, body mass index, ethnicity, and the medical condition for which the medication was taken.

The researchers observed an independent association for systemic β-blocker use with an IOP of 0.45 mm Hg lower. Conversely, there was a correlation for higher mean IOP with use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and sulfonylureas (0.33, 0.40, 0.21, and 0.34 mmHg higher, respectively). There was no interaction noted between medication classes for additive, synergistic, or antagonistic effects on IOP.

"At this point, the effect of systemic medication on IOP in eyes with glaucoma is not well elucidated but important," the authors write. "Our findings indicate that patients with glaucoma may potentially be at risk of higher or lower IOP, depending on medication class, and this would in turn affect management of IOP control."

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »