Model Predicts Development of Chronic Kidney Disease

Share this content:
Model Predicts Development of Chronic Kidney Disease
Model Predicts Development of Chronic Kidney Disease

THURSDAY, Nov. 16, 2017 (HealthDay News) -- A multivariable model that uses routine laboratory data is able to predict advanced chronic kidney disease after hospitalization with acute kidney injury, according to a study published online Nov. 14 in the Journal of the American Medical Association.

In order to derive and validate multivariable prediction models, Matthew T. James, M.D., Ph.D., from Foothills Medical Center in Canada, and colleagues used data from two population-based cohorts of patients with a prehospitalization estimated glomerular filtration rate of ≥45 mL/min/1.73m2 who had survived hospitalization with acute kidney injury. Risk models were derived from 9,973 patients hospitalized in Alberta and externally validated with data from 2,761 patients hospitalized in Ontario.

The researchers found that six variables were independently associated with progression of acute kidney injury to advanced chronic kidney disease: older age, female sex, higher baseline serum creatinine value, albuminuria, greater severity of acute kidney injury, and higher serum creatinine value at discharge. Inclusion of these factors in a multivariable model had a C statistic of 0.81 and improved discrimination and reclassification in the external validation cohort compared with reduced models that included age, sex, and discharge serum creatinine value alone or age, sex, and acute kidney injury stage alone.

"This model was able to predict advanced chronic kidney disease following hospitalization with acute kidney injury but requires evaluation of its utility in a clinical setting," conclude the authors.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »