Mitochondria-Targeted Iron Chelator Offers Photoprotection

This article originally appeared here.
Share this content:
Mitochondria-Targeted Iron Chelator Offers Photoprotection
Mitochondria-Targeted Iron Chelator Offers Photoprotection

FRIDAY, July 29, 2016 (HealthDay News) -- A mitochondria-targeted iron chelator can protect primary skin fibroblasts against the harmful effects of ultraviolet A (UVA), according to a study published in the August issue of the Journal of Investigative Dermatology.

Olivier Reelfs, Ph.D., from the University of Bath in the United Kingdom, and colleagues designed a mitochondria-targeted hexadentate iron chelator linked to mitochondria-homing SS-like peptides. They evaluated the photoprotective potential of this compound against UVA-induced oxidative damage and cell death in cultured primary skin fibroblasts.

The researchers found that the compound provided protection against UVA-induced mitochondrial damage, depletion of adenosine triphosphate, and the ensuing necrotic cell death. This effect was fully related to the iron-chelating property in the mitochondria.

"This mitochondria-targeted iron chelator has therefore promising potential for skin photoprotection against the deleterious effects of the UVA component of sunlight," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Clinician Awareness of Exercise Addiction May Be Lacking

Clinician Awareness of Exercise Addiction May Be Lacking

Screening questions should focus on emotional connection to exercise, whether it interferes with life

Overall Vagotomy Not Linked to Risk of Parkinson's Disease

Overall Vagotomy Not Linked to Risk of Parkinson's ...

But there is a trend toward lower risk of Parkinson's for patients with truncal vagotomy

Pediatricians Missing Elevated Blood Lead Levels in U.S.

Pediatricians Missing Elevated Blood Lead Levels in U.S.

In 23 of 39 reporting states, pediatric care providers identified fewer than half of children with EBLL

is free, fast, and customized just for you!

Already a member?

Sign In Now »