Misoprostol Doesn't Cut Risk of Postpartum Hemorrhage

Share this content:
Misoprostol Doesn't Cut Risk of Postpartum Hemorrhage
Misoprostol Doesn't Cut Risk of Postpartum Hemorrhage

TUESDAY, Sept. 20, 2016 (HealthDay News) -- For women in the third stage of labor, misoprostol administered with routine oxytocin does not reduce the rate of postpartum hemorrhage, according to a study published online Sept. 5 in Obstetrics & Gynecology.

Thibaud Quibel, M.D., from Poissy-Saint Germain Hospital in France, and colleagues conducted a randomized trial involving women in the first stage of labor with expected vaginal deliveries at 36 to 42 weeks of gestation. Participants received routine oxytocin and were randomized to misoprostol or placebo immediately after delivery.

After the planned interim analysis including 1,721 patients showed that misoprostol was not effective and was associated with more adverse effects, the study was discontinued. The researchers found that the rates of postpartum hemorrhage were 8.4 and 8.3 percent in the misoprostol and placebo groups, respectively (P = 0.98); severe postpartum hemorrhage rates were 1.8 and 2.4 percent, respectively (P = 0.57). Patients in the misoprostol group had maternal adverse events more frequently (fever and shivering, both P < 0.001).

"Misoprostol administered with prophylactic routine oxytocin did not reduce the rate of postpartum hemorrhage risk and increased the rate of adverse events," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

RSNA: Sleep Deprivation Appears to Affect Heart Function

RSNA: Sleep Deprivation Appears to Affect Heart Function

Small study finds lack of sleep affects blood pressure, heart rate in healthy volunteers

Three Low-Carb Meals a Day Can Lower Insulin Resistance

Three Low-Carb Meals a Day Can Lower Insulin ...

However, pre-meal exercising not helpful in reducing evening blood glucose levels

Augmented Reality, Gaming May Help Relieve Phantom Limb Pain

Augmented Reality, Gaming May Help Relieve Phantom Limb ...

Study finds exercising virtual limb can cut pain by as much as half

is free, fast, and customized just for you!

Already a member?

Sign In Now »