Midostaurin Beneficial in Advanced Systemic Mastocytosis

Share this content:
Midostaurin Beneficial in Advanced Systemic Mastocytosis
Midostaurin Beneficial in Advanced Systemic Mastocytosis

THURSDAY, June 30, 2016 (HealthDay News) -- The experimental drug midostaurin may reverse organ damage in patients with advanced systemic mastocytosis, according to a study published in the June 30 issue of the New England Journal of Medicine.

Jason Gotlib, M.D., an associate professor of medicine-hematology at the Stanford University School of Medicine in California, and colleagues at 29 medical centers around the world recruited 116 patients with advanced systemic mastocytosis, including mast-cell leukemia. All of the patients received midostaurin.

The researchers found that, overall, 60 percent of patients responded to the drug. Of patients who had an enlarged spleen, for example, 77 percent showed a reduction in the organ's size. For the most part, patients who responded to the drug saw their symptoms improve. The exceptions were nausea and vomiting, which are the most common side effects of midostaurin.

Eighteen percent of the patients had mast-cell leukemia. They typically survived for 9.4 months, whereas the usual life expectancy is less than six months, Gotlib told HealthDay. Across the whole study group, patients typically lived for almost 2.5 years. He said future studies should try combining midostaurin with other treatments, including bone marrow transplants, which have shown promise in recent research.

Novartis, which is developing midostaurin, partially funded the study.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »