Midostaurin Beneficial in Advanced Systemic Mastocytosis

Share this content:
Midostaurin Beneficial in Advanced Systemic Mastocytosis
Midostaurin Beneficial in Advanced Systemic Mastocytosis

THURSDAY, June 30, 2016 (HealthDay News) -- The experimental drug midostaurin may reverse organ damage in patients with advanced systemic mastocytosis, according to a study published in the June 30 issue of the New England Journal of Medicine.

Jason Gotlib, M.D., an associate professor of medicine-hematology at the Stanford University School of Medicine in California, and colleagues at 29 medical centers around the world recruited 116 patients with advanced systemic mastocytosis, including mast-cell leukemia. All of the patients received midostaurin.

The researchers found that, overall, 60 percent of patients responded to the drug. Of patients who had an enlarged spleen, for example, 77 percent showed a reduction in the organ's size. For the most part, patients who responded to the drug saw their symptoms improve. The exceptions were nausea and vomiting, which are the most common side effects of midostaurin.

Eighteen percent of the patients had mast-cell leukemia. They typically survived for 9.4 months, whereas the usual life expectancy is less than six months, Gotlib told HealthDay. Across the whole study group, patients typically lived for almost 2.5 years. He said future studies should try combining midostaurin with other treatments, including bone marrow transplants, which have shown promise in recent research.

Novartis, which is developing midostaurin, partially funded the study.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Aspirin, Rivaroxaban Similar After Total Hip, Knee Arthroplasty

Aspirin, Rivaroxaban Similar After Total Hip, Knee Arthroplasty

Extended prophylaxis with aspirin no different from rivaroxaban for preventing venous thromboembolism

Odds of ARDS Up After Cardiac Surgery During Flu Season

Odds of ARDS Up After Cardiac Surgery During ...

Cardiac surgery during flu season is independent risk factor for acute respiratory distress syndrome

In A-Fib Patients, Stroke Risk Higher for Blacks Than Whites

In A-Fib Patients, Stroke Risk Higher for Blacks ...

Higher risk of ischemic stroke seen before, after atrial fibrillation diagnosis compared with whites

is free, fast, and customized just for you!

Already a member?

Sign In Now »