Midlife PSA Levels Predict Future Lethal Prostate Cancer

This article originally appeared here.
Share this content:
Midlife PSA Levels Predict Future Lethal Prostate Cancer
Midlife PSA Levels Predict Future Lethal Prostate Cancer

TUESDAY, June 14, 2016 (HealthDay News) -- Prostate-specific antigen (PSA) levels in midlife predict future lethal prostate cancer (PCa) risk, according to a study published online June 13 in the Journal of Clinical Oncology.

Mark A. Preston, M.D., M.P.H., from Brigham and Women's Hospital in Boston, and colleagues conducted a nested case-control study among men aged 40 to 59 years who gave blood before being randomized in the Physicians' Health Study trial of aspirin and β-carotene. Baseline PSA levels were available for 234 patients with PCa and 711 controls matched for age; the authors then rematched 71 patients with lethal PCa to 213 controls.

The researchers found that for men aged 40 to 49, 50 to 54, and 55 to 59 years, the median PSA among controls was 0.68, 0.88, and 0.96 ng/mL. There was a strong correlation between the risk of lethal PCa and baseline PSA in midlife: comparing PSA in the >90th percentile versus less than or equal to median correlated with odds ratios of 8.7, 12.6, and 6.9 at 40 to 49 years, 50 to 54 years, and 55 to 59 years, respectively. For men aged 40 to 49, 50 to 54, and 55 to 59 years, a total of 82, 71, and 86 percent, respectively, of lethal cases occurred among those with PSA above the median.

"Risk-stratified screening on the basis of midlife PSA should be considered in men age 45 to 59 years," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

Grade B recommendation suggests substantial net benefit for screening for pre-eclampsia

Evidence Suggests Sodium Guidelines Are Misguided

Evidence Suggests Sodium Guidelines Are Misguided

Dietary sodium intake inversely associated with systolic, diastolic blood pressure in long term

Waiting 10 Months for Colonoscopy May Raise CRC Risk

Waiting 10 Months for Colonoscopy May Raise CRC ...

After positive FIT result, colonoscopy at 10 months also tied to more advanced disease

is free, fast, and customized just for you!

Already a member?

Sign In Now »