Metformin Eligibility Up With eGFR Versus Serum Creatinine

This article originally appeared here.
Share this content:
Metformin Eligibility Up With eGFR Versus Serum Creatinine
Metformin Eligibility Up With eGFR Versus Serum Creatinine

THURSDAY, Nov. 5, 2015 (HealthDay News) -- Use of estimated glomerular filtration rate (eGFR) rather than serum creatinine (sCr) can expand metformin eligibility, according to a study published in the November issue of Diabetes Care.

Delphine S. Tuot, M.D., from the University of California in San Francisco, and colleagues examined the potential impact of recommendations to use eGFR rather than sCr to determine metformin eligibility. Metformin eligibility was examined among 3,902 adults with diabetes from the 1999 to 2010 National Health and Nutrition Examination Surveys using conventional sCr thresholds and eGFR categories. Different eGFR equations were used to estimate creatinine clearance (CrCl), including four-variable Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine (CKD-EPIcr), and CKD-EPI cystatin C, as well as Cockcroft-Gault (CG).

The researchers found that MDRD eGFR ≥45 mL/min/1.73 m² was most common for men and non-Hispanic blacks among adults with sCr above conventional cut-offs (adjusted odds ratios, 33.3 versus women and 14.8 versus whites, respectively). An MDRD eGFR <30 mL/min/1.73 m² was not seen among individuals with sCr below conventional cut-offs. The population of individuals for whom metformin is likely safe was expanded with all estimating equations, ranging from 86,900 (CKD-EPIcr) to 834,800 (CG).

"The use of eGFR or CrCl to determine metformin eligibility instead of sCr can expand the adult population with diabetes for whom metformin is likely safe, particularly among non-Hispanic blacks and men," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

CDC: No Change in Level of Uninsured in U.S. in 2017

CDC: No Change in Level of Uninsured in ...

Five percent of children uninsured in 2017, 41.3 and 55.0 percent had public and private coverage

Age-Related Racial Disparity Examined in Childhood Suicide

Age-Related Racial Disparity Examined in Childhood Suicide

Significantly higher incidence of suicide for black children aged 5 to 12; lower rate for black teens

Moral Distress for Docs Providing Emergency-Only Hemodialysis

Moral Distress for Docs Providing Emergency-Only Hemodialysis

Docs describe burnout and emotional exhaustion; moral distress at seeing suffering and injustice

is free, fast, and customized just for you!

Already a member?

Sign In Now »