Metamizole Could Be Alternative to Classical NSAIDs

This article originally appeared here.
Share this content:
Metamizole Could Be Alternative to Classical NSAIDs
Metamizole Could Be Alternative to Classical NSAIDs

THURSDAY, July 14, 2016 (HealthDay News) -- Metamizole seems to be safer than other nonsteroidal anti-inflammatory drugs (NSAIDs) and causes fewer gastric and duodenal ulcers in postoperative pain management, according to a review published online June 27 in Pain Practice.

Noting that use of metamizole has been discouraged because of the risk for agranulocytosis, Jorieke Konijnenbelt-Peters, M.D., Ph.D., from Canisius Wilhelmina Ziekenhuis in Nijmegen, Netherlands, and colleagues conducted a systematic literature review to examine whether metamizole could be an alternative to classical NSAIDs in postoperative pain management.

The researchers found that there were fewer gastric and duodenal ulcers with metamizole versus other nonselective NSAIDs, with a limited risk of bleeding. It was unknown whether metamizole was safer than a nonselective NSAID together with a proton pump inhibitor. In healthy volunteers, the drug appeared to be safe for renal function, but data were lacking for high-risk patients (such as those with heart or renal failure). The incidence of metamizole-induced agranulocytosis was controversial, but in this selected group of patients, the risk was likely limited to short-term postoperative use.

"Although firm evidence is lacking, metamizole may be safer for the upper intestinal tract and kidneys than other NSAIDs, and could alternatively be used in patients with an increased risk for stomach or renal problems," the authors write. "The risk for metamizole-induced agranulocytosis is judged to be acceptable."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Warns Against Children Taking Codeine, Tramadol

FDA Warns Against Children Taking Codeine, Tramadol

Agency strengthens warning labels on these medications to address dangers

Trump Administration Offers Grants to Fight Opioid Crisis

Trump Administration Offers Grants to Fight Opioid Crisis

Money to be used to train health professionals, foster prescription drug monitoring programs

NYC to Raise Cigarette Prices to Highest in the United States

NYC to Raise Cigarette Prices to Highest in ...

Price of pack to jump from $10.50 to $13.00

is free, fast, and customized just for you!

Already a member?

Sign In Now »