Metabolites Linked to Renal Decline, Time to ESRD in T1DM

Share this content:
Metabolites Linked to Renal Decline, Time to ESRD in T1DM
Metabolites Linked to Renal Decline, Time to ESRD in T1DM

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- Serum levels of seven modified metabolites are associated with renal function decline and time to end-stage renal disease (ESRD) among patients with type 1 diabetes (T1D), according to a study published online Jan. 13 in Diabetes Care.

Monika A. Niewczas, M.D., Ph.D., from the Joslin Diabetes Center in Boston, and colleagues examined serum metabolomic profiles associated with variation in renal function decline in 158 patients with T1D with proteinuria and chronic kidney disease stage 3. Participants were followed for 11 years to determine the estimated glomerular filtration rate slopes and to ascertain time to ESRD onset.

The researchers detected 110 amino acids and purine and pyrimidine metabolites in at least 80 percent of participants. There was an association for serum levels of seven modified metabolites (C-glycosyltryptophan, pseudouridine, O-sulfotyrosine, N-acetylthreonine, N-acetylserine, N6-carbamoylthreonyladenine, and N6-acetyllysine) with renal function decline and time to ESRD (P < 0.001), which was independent of relevant clinical covariates. The significant metabolites correlated with one another and with tubular injury indices.

"This prospective cohort study in participants with T1D, proteinuria, and impaired renal function at baseline demonstrated that patients with increased circulating levels of certain modified metabolites experience faster renal function decline, leading to ESRD," the authors write. "Whether some of these candidate metabolites are risk factors or just prognostic biomarkers of progression to ESRD in T1D needs to be determined."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves Zejula for Certain Female Cancers

FDA Approves Zejula for Certain Female Cancers

PARP inhibitor may help fight tumors affecting the ovaries, fallopian tubes, or peritoneum

USPSTF: Evidence Lacking for Celiac Dz Screen in Asymptomatic

USPSTF: Evidence Lacking for Celiac Dz Screen in ...

Insufficient evidence for weighing benefits, harms of screening for celiac disease in asymptomatic

Lap, Abdominal Hysterectomy Equal for Early Endometrial CA

Lap, Abdominal Hysterectomy Equal for Early Endometrial CA

Equivalent disease-free survival at 4.5 years for stage I endometrial cancer with TAH, TLH

is free, fast, and customized just for you!

Already a member?

Sign In Now »