Metabolic Syndrome Common in Young Women With Lupus

This article originally appeared here.
Share this content:
Metabolic Syndrome Common in Young Women With Lupus
Metabolic Syndrome Common in Young Women With Lupus

THURSDAY, Sept. 17, 2015 (HealthDay News) -- Metabolic syndrome is common in young, premenopausal women with systemic lupus erythematosus (SLE), and chloroquine appears to protect against metabolic syndrome in these women, according to a study published online Aug. 26 in Arthritis Care & Research.

Luciana F. Muniz, M.D., from Faculdade de Medicina da Universidade de Sao Paulo in Brazil, and colleagues evaluated the frequency of metabolic syndrome and disease- or therapy-related factors in 103 premenopausal SLE patients (<40 years) and 35 healthy, premenopausal, age-matched women.

The researchers found a higher frequency of metabolic syndrome in the SLE group (22.3 percent versus 5.7 percent; P=0.03). Compared with those without metabolic syndrome, SLE patients with metabolic syndrome had higher SLE Disease Activity Index scores (P=0.006), more frequently had previous renal disease (73.9 percent versus 51.2 percent; P=0.05) and current renal disease (34.8 percent versus 10 percent; P=0.008), and had higher current prednisone dose (P=0.018) and cumulative prednisone dose (P=0.023). Chloroquine was less frequently used in metabolic syndrome-SLE patients (65.2 percent versus 90 percent; P=0.008). In multivariate analysis, only current chloroquine use (prevalence ratio [PR], 0.29) and cumulative prednisone were associated with metabolic syndrome (PR, 1.02).

"Chloroquine has a protective effect on the prevalence of metabolic syndrome in these patients, and this benefit counteracts the deleterious effect of glucocorticoids in a dose-dependent manner," the authors conclude.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Hormonal Contraception May Raise Depression Risk

Hormonal Contraception May Raise Depression Risk

Study also ties hormonal patches, IUDs to greater antidepressant use, especially in teens

Dose-Dependent Link Between Cannabis Use, Psychosis Relapse

Dose-Dependent Link Between Cannabis Use, Psychosis Relapse

But researchers note effect is small, and the research isn't definitive

Systolic Blood Pressure Variability Linked to Mortality, Morbidity

Systolic Blood Pressure Variability Linked to Mortality, Morbidity

Increased SBP variability tied to mortality, coronary heart disease, stroke, end-stage renal disease

is free, fast, and customized just for you!

Already a member?

Sign In Now »