Meta-Analysis: Oral Contraceptive Use Not Linked to RA Onset

This article originally appeared here.
Share this content:
Meta-Analysis: Oral Contraceptive Use Not Linked to RA Onset
Meta-Analysis: Oral Contraceptive Use Not Linked to RA Onset

(HealthDay News) -- Oral contraceptive (OC) use does not appear to be associated with the risk of rheumatoid arthritis (RA), although there is an inverse association between OC use and RA severity, according to a meta-analysis published in the International Journal of Rheumatic Diseases.

In an effort to examine the correlation between OC use and development of RA, Qi Chen, from Changhai Hospital in Shanghai, and colleagues conducted a systematic review and meta-analysis based on observational studies. Data were included for 28 studies, of which 18 were case-control, three nested case-control, and seven cohort.

The researchers found that, compared with never OC users, ever, current, and past OC users had a risk of RA of 0.69 (95 percent confidence interval [CI], 0.53 to 0.89), 0.71 (95 percent CI, 0.48 to 1.06), and 0.67 (95 percent CI, 0.44 to 1.01), respectively, in case-control studies. The corresponding odds ratios were 1.00 (95 percent CI, 0.87 to 1.15), 0.93 (95 percent CI, 0.70 to 1.23), and 0.93 (95 percent CI, 0.78 to 1.12) in prospective studies. OC use was inversely associated with RA severity (odds ratio, 0.41; 95 percent CI, 0.22 to 0.78). The correlation between OC use and RA risk was independent of OC use duration.

"OC use has no protective effect on RA onset, but appears to prevent progression to severe RA," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

Rising Fatal Drug Overdoses Linked to Years of Life Lost

Rising Fatal Drug Overdoses Linked to Years of ...

Growth in fatal overdoses linked to increased mortality, years of life lost for non-Hispanic whites

Atherosclerotic CVD Mortality Higher in South Asians in the U.S.

Atherosclerotic CVD Mortality Higher in South Asians in ...

Most of the increased risk can be attributed to increased prevalence of known risk factors

Global Variation in Personal Health Care Access and Quality

Global Variation in Personal Health Care Access and ...

Highest performance in Iceland, lowest in Central African Republic, with variation in rate of progress