Melanoma Staging Undergoes Evidence-Based Revision

Share this content:
Melanoma Staging Undergoes Evidence-Based Revision
Melanoma Staging Undergoes Evidence-Based Revision

FRIDAY, Oct. 20, 2017 (HealthDay News) -- The American Joint Committee on Cancer (AJCC) melanoma staging system has been revised, according to a report published online Oct. 13 in CA: A Cancer Journal for Clinicians.

Jeffrey E. Gershenwald, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues from the AJCC Melanoma Expert Panel assembled a large database of >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Changes in the eighth edition Cancer Staging Manual were based upon analysis of this database.

Key changes include recording tumor thickness measurements to the nearest 0.1 mm; new definitions of T1a and T1b (T1a, <0.8 mm without ulceration; T1b, 0.8 to 1 mm with or without ulceration or <0.8 mm with ulceration); revision of pathological (but not clinical) stage IA to include T1b N0 M0; N category descriptors "microscopic" and "macroscopic" for regional node metastasis are redefined as "clinically occult" and "clinically apparent"; prognostic stage III groupings are based on N category criteria and T category criteria and increased from three to four subgroups (stages IIIA-IIID); N subcategory definitions are revised, with the presence of microsatellites, satellites, or in-transit metastases now categorized as N1c, N2c, or N3c based on the number of tumor-involved regional lymph nodes, if any; additional descriptors for each M1 subcategory designation for lactate dehydrogenase; and a new M1d designation for central nervous system metastases.

"This evidence-based revision of the AJCC melanoma staging system will guide patient treatment, provide better prognostic estimates, and refine stratification of patients entering clinical trials," conclude the authors.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality ...

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination ...

Pharmacies can address cost barriers to vaccination by providing vaccines at lower cost

Single Blood Sample Test May Help ID Undiagnosed Diabetes

Single Blood Sample Test May Help ID Undiagnosed ...

Single-sample confirmatory definition associated with high positive predictive value

is free, fast, and customized just for you!




Already a member?

Sign In Now »