Mechanisms ID'd for Curcumin Resensitization of Cancer Cells

Share this content:
Mechanisms ID'd for Curcumin Resensitization of Cancer Cells
Mechanisms ID'd for Curcumin Resensitization of Cancer Cells

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Curcumin can resensitize chemoresistant pancreatic ductal adenocarcinoma (PDAC) cells through inhibition of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis, according to a study published online July 17 in Carcinogenesis.

Noting that curcumin can overcome de-novo chemoresistance and resensitize tumors to chemotherapeutic agents, Kazuhiro Yoshida, M.D., from the Baylor University Medical Center in Dallas, and colleagues examined the underlying mechanisms for curcumin-mediated chemosensitization.

The researchers reported the resensitization of chemoresistant PDAC cells by curcumin through inhibition of the PRC2-PVT1-c-Myc axis. Curcumin sensitized chemoresistant cancer cells inhibited expression of the PRC2 subunit enhancer of zeste homolog-2 and its related long non-coding RNA PVT1 using gemcitabine-resistant PDAC cell lines. Curcumin also prevented spheroid formation and down-regulated several genes driving self-renewal. In vitro findings were confirmed in a xenograft mouse model, with inhibition of gemcitabine-resistant tumor growth by curcumin.

"Overall, this study establishes clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »