May 2016 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for May 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

AHRQ Communication Toolkit Can Help After Patient Harm Occurs

TUESDAY, May 31, 2016 (HealthDay News) -- A new communication toolkit created by the Agency for Healthcare Research and Quality (AHRQ) can help health care organizations and providers communicate with patients and families when harm occurs to patients.

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Glucocorticoid Use Ups Diabetes Risk in Rheumatoid Arthritis

TUESDAY, May 31, 2016 (HealthDay News) -- For patients with rheumatoid arthritis (RA), glucocorticoid treatment is associated with increased risk of diabetes mellitus (DM), according to a study published in the May issue of Arthritis & Rheumatology.

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Remaining Uninsured May Be Difficult to Reach Via ACA

FRIDAY, May 27, 2016 (HealthDay News) -- Uninsurance rates have decreased since the introduction of the Affordable Care Act (ACA), but reaching the remaining uninsured may prove challenging, according to a health policy brief published online May 23 in Health Affairs.

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Higher HDL-C Linked to Cardiac Risk With LDL-C <2.0 mmol/L

FRIDAY, May 27, 2016 (HealthDay News) -- For patients with type 2 diabetes with low-density lipoprotein cholesterol (LDL-C) levels <2.0 mmol/L, higher high-density lipoprotein cholesterol (HDL-C) is associated with increased risk for cardiovascular events and all-cause mortality, according to a study published online May 23 in Diabetes Care.

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Hip Fracture Incidence Up With Non-Dialysis-Requiring CKD

FRIDAY, May 27, 2016 (HealthDay News) -- The incidence of hip fracture and post-hip fracture mortality are increased for patients with non-dialysis-requiring chronic kidney disease (CKD), according to a study published online May 4 in the Journal of Bone and Mineral Research.

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Recognition of Patient Expertise Can Improve Adherence

FRIDAY, May 27, 2016 (HealthDay News) -- Recognizing the unique role of patients and their expertise within the physician-patient interaction can help to prevent non-adherence based on disagreement, according to an article published online May 18 in the Journal of Evaluation in Clinical Practice.

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Renal Function Decline Linked to Major Adverse CV Events

THURSDAY, May 26, 2016 (HealthDay News) -- The risk of major adverse cardiovascular events (MACE) is increased with renal function decline, according to a study published online May 23 in Diabetes Care.

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Prolactin Receptor Signaling Linked to Expansion of β-Cells

THURSDAY, May 26, 2016 (HealthDay News) -- Prolactin receptor (PRLR) signaling plays a role in expansion of maternal β-cells during pregnancy, according to a study published online May 23 in Diabetes.

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Study Upholds Link Between Air Pollution and Higher CVD Risk

WEDNESDAY, May 25, 2016 (HealthDay News) -- Air pollution can worsen cardiovascular disease risk factors, especially in patients with diabetes, according to a study published online May 24 in the Journal of Clinical Endocrinology & Metabolism.

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Low Levels of Hormone Associated With Teen Obesity

WEDNESDAY, May 25, 2016 (HealthDay News) -- Obese adolescents may have lower levels of the hormone spexin than normal-weight adolescents, according to research published online May 24 in the Journal of Clinical Endocrinology & Metabolism.

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Guidelines Issued for Recommending Metabolic Surgery

WEDNESDAY, May 25, 2016 (HealthDay News) -- Weight-loss surgery quickly improves glycemic control in patients with type 2 diabetes, and should be recommended or considered as a treatment for certain obese patients with diabetes, according to a report in the June issue of Diabetes Care.

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City Planning for Walkability May Help Curb Diabetes Rates

WEDNESDAY, May 25, 2016 (HealthDay News) -- Pedestrian-friendly ("walkable") neighborhoods have reduced rates of diabetes, according to research published in the May 24/31 issue of the Journal of the American Medical Association.

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Plastics Chemical BBP Exposure May 'Program' Obesity

WEDNESDAY, May 25, 2016 (HealthDay News) -- Benzyl butyl phthalate (BBP) regulates the mesenchymal stem cell (MSC) toward adipogenesis by inducing epigenetic stress, according to research published online May 6 in Molecular and Cellular Endocrinology.

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Health Coaches Can Help Increase Patient Engagement

TUESDAY, May 24, 2016 (HealthDay News) -- Introducing health coaches who can take on responsibilities to advance lifestyle changes, prevention, and patient health can help to increase patient satisfaction and engagement, according to the American Medical Association.

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Metformin Combats Adipose Tissue Expansion Via AMPK

TUESDAY, May 24, 2016 (HealthDay News) -- AMPK activation by metformin is associated with inhibition of interstitial fibrosis and suppression of transforming growth factor β-1 (TGF-β1), according to a study published online May 13 in Diabetes.

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AAP Recommends at Least One Full-Time Nurse in Every School

MONDAY, May 23, 2016 (HealthDay News) -- Every school should have at least one full-time registered nurse, according to a new American Academy of Pediatrics (AAP) policy statement published online May 23 in Pediatrics.

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FDA Redesigns Nutrition Facts Label

MONDAY, May 23, 2016 (HealthDay News) -- The Nutrition Facts panel on packaged foods in the United States is about to undergo long-awaited changes, with a redesign emphasizing realistic portion sizes and added sugars.

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Changes in Adipose Tissue With Lack of Insulin, IGF-1 Receptors

MONDAY, May 23, 2016 (HealthDay News) -- Mice lacking either the insulin receptor (IR), insulin-like growth factor 1 receptor (IGF1R), or both have disruptions in white and brown adipose tissue (WAT and BAT) formation, with an almost complete absence of WAT and BAT in mice lacking both receptors, according to a study published online May 13 in Diabetes.

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Study Suggests a Low-Salt Diet Could Harm Certain Patients

MONDAY, May 23, 2016 (HealthDay News) -- Restricting dietary salt to below 3,000 mg a day appears to increase the risk for cardiovascular disease similar to that of hypertension patients who eat too much salt, according to research published online May 20 in The Lancet.

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Danazol Treatment Linked to Telomere Elongation

FRIDAY, May 20, 2016 (HealthDay News) -- In patients with telomere diseases, treatment with the synthetic sex hormone danazol is associated with telomere elongation, according to a study published in the May 18 issue of the New England Journal of Medicine.

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Lifestyle Intervention Before Infertility Treatment No Benefit

FRIDAY, May 20, 2016 (HealthDay News) -- A lifestyle intervention preceding infertility treatment does not result in higher rates of vaginal birth among obese infertile women, according to a study published in the May 19 issue of the New England Journal of Medicine.

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Major Stroke May Be Prevented by Taking Aspirin After TIA

FRIDAY, May 20, 2016 (HealthDay News) -- Taking aspirin immediately after a transient ischemic attack (TIA) significantly reduces the risk of a major stroke, according to research published online May 18 in The Lancet.

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Early Loss of Islet Sympathetic Nerves in Type 1 Diabetes

FRIDAY, May 20, 2016 (HealthDay News) -- Early, marked, and sustained loss of islet sympathetic nerves is seen in type 1, but not type 2, diabetes mellitus, according to a study published online May 13 in Diabetes.

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Sulfonylureas May Inhibit KATP Channel Neuroprotection

FRIDAY, May 20, 2016 (HealthDay News) -- Treatment with sulfonylureas (ATP-sensitive potassium [KATP] channel blockers) may inhibit the neuroprotective effects of KATP channel activation and increase the risk of stroke, according to an experimental study published online May 13 in Diabetes.

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Strategies Can Help Streamline Revenue-Related Processes

THURSDAY, May 19, 2016 (HealthDay News) -- Strategies can be employed to maximize the amount of time available for patient care by streamlining revenue-related processes, according to the American Medical Association (AMA).

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Nocturnal Hypoglycemia Often Occurs in Children With T1DM

THURSDAY, May 19, 2016 (HealthDay News) -- Nocturnal hypoglycemia frequently occurs in children with type 1 diabetes, and is mainly asymptomatic, according to a research letter published online May 13 in Diabetes Care.

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Worse Outcomes for GDM With Impaired Insulin Sensitivity

THURSDAY, May 19, 2016 (HealthDay News) -- Among women with gestational diabetes mellitus (GDM), impaired insulin sensitivity, but not insulin secretion defects, is associated with a greater risk of adverse outcomes compared with normal glucose tolerance (NGT), according to a study published online May 13 in Diabetes Care.

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Self-Measured Waist Circumference Often Falls Short

THURSDAY, May 19, 2016 (HealthDay News) -- Self-measured waist circumference has a clinically important false-negative rate compared with professionally-measured waist circumference, according to a study published in the May/June issue of the Annals of Family Medicine.

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Burnout, Lack of Job Satisfaction Driving Doctors to Cut Hours

WEDNESDAY, May 18, 2016 (HealthDay News) -- Full-time physicians reporting worsening burnout or decreased job satisfaction are more likely to reduce their work hours, according to a study published in the April issue of Mayo Clinic Proceedings.

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Diabetic Ketoacidosis Can Occur Post Bariatric Surgery in T2DM

WEDNESDAY, May 18, 2016 (HealthDay News) -- Diabetic ketoacidosis (DKA) can occur after bariatric surgery in patients with type 2 diabetes, according to a report published online May 10 in Diabetes Care.

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Skeletal Muscle TRIB3 Mediates Diet-Induced Insulin Resistance

WEDNESDAY, May 18, 2016 (HealthDay News) -- Skeletal muscle TRIB3 mediates glucose-induced insulin resistance (GIIR) in a mouse model of diabetes, according to a study published online May 10 in Diabetes.

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IOM Committee Finds Genetically Engineered Crops Safe

WEDNESDAY, May 18, 2016 (HealthDay News) -- Crops created through genetic engineering are as safe to eat as crops developed through traditional plant-breeding methods, according to the National Academies of Sciences, Engineering, and Medicine.

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Sexual Harassment Experienced by One-Third of Female Doctors

WEDNESDAY, May 18, 2016 (HealthDay News) -- Thirty percent of female physicians face sexual harassment on the job, while close to three-quarters perceive gender bias at work and two-thirds say they have actually experienced it, according to survey findings published in the May 17 issue of the Journal of the American Medical Association.

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About Half of Myocardial Infarctions Are Asymptomatic

TUESDAY, May 17, 2016 (HealthDay News) -- As many as half of all myocardial infarctions (MIs) may be silent, according to a study published online May 16 in Circulation.

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Wine Beats Other Types of Alcohol in Reduction of T2DM Risk

TUESDAY, May 17, 2016 (HealthDay News) -- Wine is associated with a greater decrease in the risk of type 2 diabetes than beer or spirits, according to a review published online May 11 in the Journal of Diabetes Investigation.

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Obesity, RYGB Impact Skeletal Muscle Proteome

TUESDAY, May 17, 2016 (HealthDay News) -- Obesity and Roux-en-Y gastric bypass (RYGB) affect the skeletal muscle proteome, with changes in protein abundance in skeletal muscle before and after RYGB surgery, according to a study published online May 10 in Diabetes.

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Trans-Resveratrol, Hesperetin Up Glo1 Expression, Metabolic Health

MONDAY, May 16, 2016 (HealthDay News) -- For overweight and obese subjects, trans-resveratrol (tRES) and hesperetin (HESP) coformulation increases glyoxalase 1 (Glo1) expression and produces improvements in metabolic and vascular health, according to a study published online May 11 in Diabetes.

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CABG Underused in Diabetes With Multivessel Disease

MONDAY, May 16, 2016 (HealthDay News) -- About one-third of patients with diabetes mellitus and multivessel coronary artery disease presenting with non-ST-segment elevation myocardial infarction undergo coronary artery bypass graft (CABG) and more undergo percutaneous coronary intervention (PCI), according to a study published online May 10 in Circulation: Cardiovascular Quality and Outcomes.

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Complementary Medicine Use Up With Chronic Conditions

MONDAY, May 16, 2016 (HealthDay News) -- Adults with multiple chronic conditions frequently use complementary and alternative medicine (CAM), according to a study published online May 5 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Neuronal GHS-R Involved in Regulating Energy Metabolism

FRIDAY, May 13, 2016 (HealthDay News) -- Neuronal growth hormone secretagogue receptor (GHS-R) is involved in regulating energy metabolism, according to an experimental study published online May 10 in Diabetes.

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Gestational DM Tied to Greater Total Adipose Tissue in Infants

FRIDAY, May 13, 2016 (HealthDay News) -- Infants born to mothers who had gestational diabetes mellitus (GDM) may be more likely to carry excess fat in early life, according to research published online May 12 in Diabetes Care.

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Lower Levels of Vitamin D Receptors in Alopecia

FRIDAY, May 13, 2016 (HealthDay News) -- Patients with alopecia areata (AA) and androgenetic alopecia (AGA) have significantly lower serum and tissue levels of vitamin D receptors (VDRs), according to a study published online May 6 in the Journal of Cosmetic Dermatology.

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Artificial Pancreas Protocol Deemed Feasible for Younger Kids

THURSDAY, May 12, 2016 (HealthDay News) -- A child-specific version of the modular model predictive control (MMPC) algorithm is feasible and safe for 5- to 9-year-old children with type 1 diabetes, according to the first outpatient single-hormone artificial pancreas (AP) trial in a population of this age, published online May 10 in Diabetes Care.

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Prevalence of Gestational Diabetes Varies Across Seasons

THURSDAY, May 12, 2016 (HealthDay News) -- The prevalence of gestational diabetes mellitus (GDM) varies across the seasons, with higher prevalence in the summer and lower prevalence in the winter, according to a study published online May 10 in Diabetes Care.

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Pop-Up Messages Up Physician Awareness of Osteoporosis

THURSDAY, May 12, 2016 (HealthDay News) -- The introduction of pop-up messages relating to a history of dual-energy X-Ray absorptiometry (DXA) in an order communication system can increase the rates of DXA prescription, as well as the rates of osteoporosis medication and exercise, according to a study published online May 6 in the Journal of Evaluation in Clinical Practice.

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Metreleptin Ups Resting-State Connectivity in Lipodystrophy

WEDNESDAY, May 11, 2016 (HealthDay News) -- For patients with lipodystrophy (LD), resting-state connectivity is significantly increased in three brain areas with metreleptin treatment, with decreased hunger feelings and diminished incentive value of food, according to a study published online May 10 in Diabetes.

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Excess Weight May Not Equal Early Mortality After All

WEDNESDAY, May 11, 2016 (HealthDay News) -- The body mass index (BMI) linked to the lowest rate of all-cause early mortality is rising, according to a study published in the May 10 issue of the Journal of the American Medical Association.

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High Maternal Glucose May Adversely 'Imprint' Baby

WEDNESDAY, May 11, 2016 (HealthDay News) -- A mother's excess weight gain or elevated blood glucose levels in pregnancy may put her child at increased risk for being overweight or obese, according to a study published online May 6 in Maternal and Child Health Journal.

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Cutting Brand-Name Drug Use Could Save U.S. $73 Billion

TUESDAY, May 10, 2016 (HealthDay News) -- Americans could save tens of billions of dollars with more efficient drug use, replacing brand-name drugs with their generic equivalents whenever possible, according to a study published online May 9 in JAMA Internal Medicine.

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CDC Establishes New 'Clean Hands Count' Campaign

MONDAY, May 9, 2016 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention has introduced a new campaign, "Clean Hands Count," to encourage health care professionals, patients, and patients' families to keep their hands clean in order to prevent health care-associated infections.

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Preadmission SSRI Use Ups Stroke Mortality in Diabetes

MONDAY, May 9, 2016 (HealthDay News) -- For patients with diabetes, preadmission selective serotonin reuptake inhibitor (SSRI) use is associated with increased risk of stroke mortality, according to a study published online May 3 in the Journal of Internal Medicine.

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Physician Leadership Training May Help Counteract Burnout

WEDNESDAY, May 4, 2016 (HealthDay News) -- Physician leaders with good leadership qualities are more likely to have employees who are satisfied and do not show signs of burnout, according to a study published in the April issue of the Mayo Clinic Proceedings and a report published by the American Medical Association.

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Adiposity Genetic Risk Score Tied to Cardiometabolic Health

WEDNESDAY, May 4, 2016 (HealthDay News) -- Data from a large cohort have replicated the association between the genetic risk score of 11 favorable adiposity variants with lower risk of cardiometabolic disease, according to research published online April 26 in Diabetes.

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Price Transparency Tool Doesn't Cut Health Care Spending

WEDNESDAY, May 4, 2016 (HealthDay News) -- Employee use of a price transparency tool does not cut health care spending, according to a study published in the May 3 issue of the Journal of the American Medical Association.

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Infant Viral Infections Might Raise Risk of Type 1 Diabetes

TUESDAY, May 3, 2016 (HealthDay News) -- Respiratory and viral infections in the first six months of life may increase the odds of a child developing type 1 diabetes by nearly 20 percent, according to a study published in the May 3 issue of the Journal of the American Medical Association.

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Report: Why Health Care Costs Are Lower in Europe Than U.S.

TUESDAY, May 3, 2016 (HealthDay News) -- European residents have access to the same health care services as U.S. residents but pay much less, and this is related to several specific factors, according to a report published by INDIGOMED on April 25.

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All-Cause, CVD, DM Mortality Down From 2000 to 2011

TUESDAY, May 3, 2016 (HealthDay News) -- All-cause and certain cause-specific mortality rates have decreased recently among those with type 1 and 2 diabetes, although younger patients have seen less improvement, according to a study published online April 26 in Diabetes Care.

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Artemisia Extract Ups Insulin Sensitivity in GDM

TUESDAY, May 3, 2016 (HealthDay News) -- For women with gestational diabetes mellitus, daily administration of Artemisia extract is associated with improved insulin sensitivity, according to a study published online April 27 in the Journal of Clinical Pharmacology.

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2017 May Offer Fewer Choices for Affordable Care Act Enrollees

MONDAY, May 2, 2016 (HealthDay News) -- With the nation's largest health insurer exiting all but a few Affordable Care Act exchanges next year, some Americans may be left with fewer choices and some might see higher monthly premiums.

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Exenatide Reduces Liver Fat in Type 2 Diabetes With Obesity

MONDAY, May 2, 2016 (HealthDay News) -- For patients with obesity and type 2 diabetes, exenatide reduces epicardial adipose tissue (EAT) and liver fat content, according to a study published online April 23 in Diabetes, Obesity and Metabolism.

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Updated Recs Aim to Expand Primary Aldosteronism Screening

MONDAY, May 2, 2016 (HealthDay News) -- The Endocrine Society has issued new guidelines intended to increase screening for primary aldosteronism. The Clinical Practice Guideline was published online March 2 in The Journal of Clinical Endocrinology & Metabolism.

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Serum Prolactin in Pregnancy Predicts Prediabetes/Diabetes

MONDAY, May 2, 2016 (HealthDay News) -- Serum prolactin in pregnancy predicts the risk of postpartum prediabetes/diabetes, according to a study published online April 26 in Diabetes Care.

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