Maximum BMI Over 16 Years Ups Risk of All-Cause Death

Share this content:
Maximum BMI Over 16 Years Ups Risk of All-Cause Death
Maximum BMI Over 16 Years Ups Risk of All-Cause Death

TUESDAY, April 4, 2017 (HealthDay News) -- Maximum body mass index (BMI) over 16 years of weight history is associated with increased risk of all-cause death, according to a study published online April 4 in the Annals of Internal Medicine.

Edward Yu, from the Harvard T.H. Chan School of Public Health in Boston, and colleagues examined the correlation between maximum BMI over 16 years and mortality in 225,072 men and women from the Nurses' Health Study I and II and the Health Professionals Follow-Up Study. Over a mean follow-up of 12.3 years, 32,571 deaths were observed.

The researchers found that maximum BMIs in the overweight, obese I, and obese II categories correlated with increases in the risk for all-cause death (multivariate hazard ratios, 1.06, 1.24, and 1.73, respectively). Across strata defined by smoking status, sex, and age, the pattern of excess risk with a maximum BMI above normal weight was maintained, with greatest excess seen for those younger than 70 years and never smokers. When BMI was defined using a single baseline measure, there was a significant inverse association between overweight and mortality (hazard ratio, 0.96). Maximum overweight correlated with increased cause-specific mortality, including cardiovascular death and coronary heart disease death.

"The paradoxical association between overweight and mortality is reversed in analyses incorporating weight history," the authors write. "Maximum BMI may be a useful metric to minimize reverse causation bias associated with a single baseline BMI assessment."

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

ACG: Diphenhydramine Ups Sedation in Chronic Opioid Users

ACG: Diphenhydramine Ups Sedation in Chronic Opioid Users

Improvement in sedation scores for patients using chronic opioids scheduled to undergo colonoscopy

Online Ratings Not Aligned With Objective Quality Measures

Online Ratings Not Aligned With Objective Quality Measures

In addition, consumer ratings are consistent across platforms for specialist physicians

Most Female Physicians Have Faced Sexist Patient Comments

Most Female Physicians Have Faced Sexist Patient Comments

Sexual harassment by patients can negatively affect physician-patient relationship, quality of care

is free, fast, and customized just for you!

Already a member?

Sign In Now »