March 2016 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for March 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Pioglitazone Linked to Increased Risk of Bladder Cancer

THURSDAY, March 31, 2016 (HealthDay News) -- For patients with type 2 diabetes newly treated with antidiabetic drugs, use of pioglitazone is associated with an increased risk of bladder cancer, with duration-response and dose-response correlations, according to a study published online March 30 in The BMJ.

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Higher Weight in First Year May Up Risk of Islet Autoimmunity

WEDNESDAY, March 30, 2016 (HealthDay News) -- Development of islet autoimmunity and multiple islet autoantibodies appears to be related to weight z-scores at age 12 months, according to a study published online March 23 in Diabetes.

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AMA Addresses Elements of Team-Based Care Model

TUESDAY, March 29, 2016 (HealthDay News) -- The elements of a team-based care model are described in a report published by the American Medical Association (AMA).

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Intensive Glucose Control Offers Lasting Reduction in Risk of ESKD

TUESDAY, March 29, 2016 (HealthDay News) -- For patients with type 2 diabetes, intensive glucose control has long-term benefits for preventing end-stage kidney disease (ESKD), according to a study published online March 22 in Diabetes Care.

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Sex Hormones, Inflammation Affect Asthma in Obese Women

TUESDAY, March 29, 2016 (HealthDay News) -- Sex hormones and systemic inflammation may be mediating the obese-asthma phenotype, according to a study published online March 23 in Allergy.

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CDC: Tips Anti-Smoking Ad Campaign Still Having Impact

MONDAY, March 28, 2016 (HealthDay News) -- Three years into the campaign, ads targeting smoking are still having a significant impact, according to the U.S. Centers for Disease Control and Prevention.

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How Can We Fix the Wage Gap Among Female Physicians?

MONDAY, March 28, 2016 (HealthDay News) -- Women doctors can address the gender wage disparity by understanding the reasons why they earn less, according to a report published in Medical Economics.

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Delayed Diagnosis of Acromegaly Reported in Elderly Woman

MONDAY, March 28, 2016 (HealthDay News) -- In a letter to the editor published in the March issue of the Journal of the American Geriatrics Society, delayed diagnosis of acromegaly is described in an elderly woman who initially presented with cutis verticis gyrata (CVG).

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Teens With Autism More Likely to Develop Type 2 Diabetes

MONDAY, March 28, 2016 (HealthDay News) -- Adolescents and young adults with autism spectrum disorder (ASD) are more likely to develop type 2 diabetes mellitus (T2DM), according to a study published online March 22 in Diabetes Care.

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Surgeons With >25 Cases a Year Optimal for Thyroid Removal

FRIDAY, March 25, 2016 (HealthDay News) -- Patients who have their thyroidectomy performed by a surgeon who does more than 25 such procedures a year tend to have fewer complications, according to a study published online March 8 in the Annals of Surgery.

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Medicare May Soon Cover Diabetes Prevention Program

FRIDAY, March 25, 2016 (HealthDay News) -- Medicare could soon pay for a program aimed at diabetes prevention, the U.S. Department of Health and Human Services announced this week.

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Incretin-Based Drugs Don't Up Heart Failure Hospitalization Risk

THURSDAY, March 24, 2016 (HealthDay News) -- Incretin-based drugs are not associated with increased risk of hospitalization for heart failure, according to a study published in the March 24 issue of the New England Journal of Medicine.

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BPA Alternative, Bisphenol S, Can Induce Fat Cell Formation

WEDNESDAY, March 23, 2016 (HealthDay News) -- Bisphenol S (BPS) induces adipogenesis in primary human preadipocytes, according to a study published online March 22 in Endocrinology.

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Sweat-Sensing Device Designed to Regulate Glucose Levels

TUESDAY, March 22, 2016 (HealthDay News) -- An experimental device uses a patch to monitor blood glucose levels via sweat, and delivers metformin through the skin with microneedles, according to findings published online March 21 in Nature Nanotechnology.

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MODY1 Form of Diabetes May Require Alternate Treatment

TUESDAY, March 22, 2016 (HealthDay News) -- Patients with maturity-onset diabetes of the young 1 (MODY1) are often misdiagnosed as having type 2 diabetes, but patients with MODY1 might benefit from therapies that target a specific pathway that appears to be essential to the function of insulin-secreting cells, according to an experimental study published online Jan. 20 in the Journal of Biological Chemistry.

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FDA: Most Powdered Medical Gloves Should Be Banned in U.S.

MONDAY, March 21, 2016 (HealthDay News) -- The U.S. Food and Drug Administration wants to ban most powdered medical gloves, saying they pose serious health risks to patients and health care providers alike.

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Exercise Prevents Diet-Induced Cell Senescence in Adipose Tissue

MONDAY, March 21, 2016 (HealthDay News) -- A novel mechanism has been proposed for the role of exercise in mitigating the detrimental impact of a fast-food diet (FFD) in mice, via prevention of cellular senescence, according to an experimental study published March 16 in Diabetes.

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Case Report: Immobility-Induced Hypercalcemia in Infant

FRIDAY, March 18, 2016 (HealthDay News) -- A rare case of immobility-induced hypercalcemia in an infant has been documented in a case report published online March 18 in Pediatrics.

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Case Before Supreme Court May Expose Doctors to Large Fines

FRIDAY, March 18, 2016 (HealthDay News) -- A case before a state supreme court could potentially expose physicians to large fines based on a legal technicality relating to what they should have known, rather than what they knew, according to the American Medical Association (AMA).

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Highest Diabetes Prevalence in Poorest Countries

FRIDAY, March 18, 2016 (HealthDay News) -- Diabetes prevalence is highest in poorer countries, even after adjustment for traditional risk factors, according to a study published online March 10 in Diabetes Care.

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Vitamin D May Help Avert Early Onset of Insulin Resistance

THURSDAY, March 17, 2016 (HealthDay News) -- Early intervention with vitamin D in deficient individuals may help ward off early onset of insulin resistance, according to a study published online Feb. 18 in Diabetes, Obesity and Metabolism.

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Diabetes Management Program Doesn't Cut Disparities in Care

THURSDAY, March 17, 2016 (HealthDay News) -- A telephone-based disease management program delivered by a disease management vendor is ineffective in reducing racial/ethnic disparities in diabetes care, according to a study published online March 10 in Diabetes Care.

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Spending on Prescription Meds Up About 5 Percent in 2015

THURSDAY, March 17, 2016 (HealthDay News) -- Spending on prescription medications for insured Americans increased about 5 percent in 2015, with the increase half of that seen in 2014, the Associated Press reported.

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FDA Safety Announcement Affected Bisphosphonate Use

WEDNESDAY, March 16, 2016 (HealthDay News) -- A U.S. Food and Drug Administration safety announcement relating to atrial fibrillation risk associated with bisphosphonates correlated with a reduction in bisphosphonate use, according to a study published online March 11 in the Journal of Bone and Mineral Research.

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Disruptive Patients Distract Docs, May Receive Compromised Care

WEDNESDAY, March 16, 2016 (HealthDay News) -- Disruptive patients may get worse care from physicians, according to a study published online March 7 in BMJ Quality & Safety. The findings aren't definitive because the researchers tested how physicians responded in fictional vignettes, instead of real-life encounters. Still, the results suggest that such patients distract physicians from doing their jobs.

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Distal Symmetric Polyneuropathy Linked to MetS Components

WEDNESDAY, March 16, 2016 (HealthDay News) -- Distal symmetric polyneuropathy (DSP) prevalence increases with an increasing number of components of metabolic syndrome, according to a study published online March 10 in Diabetes Care.

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Mayo Clinic Has Established Model to Help Battle Burnout

TUESDAY, March 15, 2016 (HealthDay News) -- In an effort to reduce burnout among physicians, the Mayo Clinic is initiating a model to raise camaraderie and increase collaboration, according to a report published by the American Medical Association (AMA).

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Abruptly Quitting Appears to Work Best for Smoking Cessation

TUESDAY, March 15, 2016 (HealthDay News) -- Quitting cigarettes "cold turkey" beats a more gradual approach, according to research published online March 15 in the Annals of Internal Medicine.

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Off-Label Use of Metformin Common in U.S. Adolescents

TUESDAY, March 15, 2016 (HealthDay News) -- In U.S. adolescents, off-label use of metformin is common, according to a study published online March 9 in the Journal of Clinical Pharmacy and Therapeutics.

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More Variability in Overnight Insulin Requirements in T1DM

TUESDAY, March 15, 2016 (HealthDay News) -- For individuals with type 1 diabetes, overnight insulin requirements are significantly more variable than daytime and total daily insulin requirements during closed-loop insulin delivery, according to a study published online March 10 in Diabetes Care.

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Guidance Offered for Negotiating Higher Rates From Payers

MONDAY, March 14, 2016 (HealthDay News) -- Negotiations to increase payment from insurance companies can be extremely difficult, although it is possible to get a payment increase, according to a report published in Medical Economics.

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HIIT May Be Most Effective Exercise Method for Obese Youth

MONDAY, March 14, 2016 (HealthDay News) -- For obese youth, high-intensity interval training (HIIT) appears to be more effective for improving blood pressure and aerobic capacity than other forms of exercise, according to a meta-analysis published online March 7 in Obesity Reviews.

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E-Consultations Can Improve Access to, Timeliness of Care

MONDAY, March 14, 2016 (HealthDay News) -- Electronic consultation (e-consultation), an asynchronous, non-face-to-face consultation between a primary care physician and a specialist, can improve access to care and reduce wait times, according to a study published in the March/April issue of the Annals of Family Medicine.

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Antihyperglycemic Medication Prescribing Trends Are Changing

MONDAY, March 14, 2016 (HealthDay News) -- Trends indicate a reduction in glyburide and thiazolidinedione prescriptions and increases in gliclazide and dipeptidyl peptidase-4 inhibitor prescriptions among older adults with diabetes and chronic kidney disease, according to a study published online March 4 in Diabetes, Obesity and Metabolism.

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Diabetes Patients More Susceptible to Staph Bacteremia

FRIDAY, March 11, 2016 (HealthDay News) -- Patients with diabetes may be significantly more likely to develop community-acquired Staphylococcus aureus bacteremia (CA-SAB) than those without diabetes, according to a study published online March 10 in the European Journal of Endocrinology.

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Evidence Links Agent Orange to Bladder Cancer, Hypothyroidism

FRIDAY, March 11, 2016 (HealthDay News) -- There is stronger evidence of a link between the herbicide Agent Orange and bladder cancer and hypothyroidism among U.S. military personnel exposed to the chemical during the Vietnam War, a new Institute of Medicine report shows.

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Five Strategies Employed to Help Promote Behavior Change

FRIDAY, March 11, 2016 (HealthDay News) -- Five key strategies are employed by clinicians to help promote patient behavior change, according to a study published in the March/April issue of the Annals of Family Medicine.

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Study Raises Privacy Concerns for Health Care Apps

THURSDAY, March 10, 2016 (HealthDay News) -- Privacy policies for health programs -- or "apps" -- designed for smartphones that share highly sensitive medical information between patients and doctors are lacking, and often are completely missing, according to a study published in the March 8 issue of the Journal of the American Medical Association.

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Too Few Patients With Prediabetes Are Being Treated

WEDNESDAY, March 9, 2016 (HealthDay News) -- A large number of Americans with prediabetes aren't being treated for the condition, which suggests that doctors are missing opportunities to prevent diabetes, according to research published in the March-April issue of the Journal of the American Board of Family Medicine.

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Physicians' Contracts Can Affect Patients, Professionalism

WEDNESDAY, March 9, 2016 (HealthDay News) -- Problematic clauses in physicians' contracts can impact patient care and professionalism, according to an Ideas and Opinions piece published online March 8 in the Annals of Internal Medicine.

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CPAP Improves Glycemic Control in Patients With T2DM, OSA

WEDNESDAY, March 9, 2016 (HealthDay News) -- For patients with obstructive sleep apnea (OSA) and suboptimally controlled type 2 diabetes, use of continuous positive airway pressure (CPAP) for six months is associated with improved glycemic control and insulin resistance, according to a study published online Feb. 24 in the American Journal of Respiratory and Critical Care Medicine.

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Vitamin D Not Beneficial for Osteoarthritis of the Knee

WEDNESDAY, March 9, 2016 (HealthDay News) -- Vitamin D supplements don't appear to relieve pain or slow the progression of knee osteoarthritis in patients with low levels of the vitamin, according to a study published in the March 8 issue of the Journal of the American Medical Association.

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Low Testosterone Predicts Mortality in Advanced Liver Disease

TUESDAY, March 8, 2016 (HealthDay News) -- For men with advanced liver disease, sarcopenia and low testosterone predict mortality, with better prediction for low testosterone, according to a study published in the March issue of the Journal of Gastroenterology and Hepatology.

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Body Fat May Be Bigger Health Danger Than Body Size

TUESDAY, March 8, 2016 (HealthDay News) -- Body mass index (BMI) may not accurately reflect a person's body composition, or be a good indicator of health, according to research published online March 8 in the Annals of Internal Medicine.

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Opportunities for Healthy Diet, Exercise Influence Behaviors

TUESDAY, March 8, 2016 (HealthDay News) -- Practical opportunities for healthy diet and activity are associated with intentions, achieved behaviors, and body mass index (BMI), according to a study published in the March/April issue of the Annals of Family Medicine.

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Maternal Vitamin D Deficiency May Up MS Risk in Offspring

TUESDAY, March 8, 2016 (HealthDay News) -- Maternal serum 25-hydroxyvitamin D (25[OH]D) deficiency in early pregnancy is associated with increased risk of multiple sclerosis (MS) in offspring, according to a study published online March 7 in JAMA Neurology.

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Cold Exposure, Capsinoids Further Beige Adipocyte Biogenesis

TUESDAY, March 8, 2016 (HealthDay News) -- A molecular circuit has been identified that controls beige adipocyte biogenesis, according to research published online March 2 in Diabetes.

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Chemical Exposure Down With Switch in Cosmetics Among Teens

MONDAY, March 7, 2016 (HealthDay News) -- Switching to chemical-free cosmetics and shampoos quickly lowers levels of hormone-disrupting chemicals in the bodies of adolescent girls, according to a study published online March 7 in Environmental Health Perspectives.

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Annual Visit Rate for Obesity Is 49 Visits Per 1,000 Persons

THURSDAY, March 3, 2016 (HealthDay News) -- In 2012 there were 11 million visits to health care providers for obesity, with variation in visit rates by age and sex, according to a March data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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ADA Issues Recs for Management of Diabetes in Primary Care

THURSDAY, March 3, 2016 (HealthDay News) -- New recommendations have been developed for diabetes, focusing on areas of importance for primary care providers. The clinical guideline was published online March 1 in the Annals of Internal Medicine.

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SCOTUS: States Can't Force Health Care Data Release

WEDNESDAY, March 2, 2016 (HealthDay News) -- The Supreme Court has ruled against state efforts to collect health care data from insurance plans.

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Spouse Education Level May Impact Choice for Rural Practice

WEDNESDAY, March 2, 2016 (HealthDay News) -- Physicians who are married to a highly-educated spouse are less likely to work in rural underserved areas, according to a study published in the March 1 issue of the Journal of the American Medical Association.

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Type 1 Diabetes Linked to Increased Risk of Certain Cancers

WEDNESDAY, March 2, 2016 (HealthDay News) -- Individuals with type 1 diabetes appear to have a higher risk for cancers of the stomach, liver, pancreas, endometrium, ovary, and kidneys, but a reduced risk for prostate and breast cancers, according to research published online Feb. 29 in Diabetologia.

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Insulin Degludec/Liraglutide Noninferior to Insulin Glargine

WEDNESDAY, March 2, 2016 (HealthDay News) -- For patients with uncontrolled type 2 diabetes, a fixed ratio of insulin degludec/liraglutide is noninferior to continued titration of insulin glargine, according to a study published in the March 1 issue of the Journal of the American Medical Association.

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Metabolic Syndrome Tied to Risk of Mild Cognitive Impairment

WEDNESDAY, March 2, 2016 (HealthDay News) -- The incidence of mild cognitive impairment (MCI) and MCI progression to dementia is increased in association with metabolic syndrome (MetS), according to a study published online Feb. 29 in JAMA Neurology.

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Anti-VEGF Agents Linked to Visual Acuity Improvement in DME

TUESDAY, March 1, 2016 (HealthDay News) -- For patients with diabetic macular edema (DME), visual acuity (VA) improves over two years with treatment with different anti-vascular endothelial growth factor (VEGF) agents, according to a study published online Feb. 27 in Ophthalmology.

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Uric Acid Levels Low in Teens With Type 1 Diabetes

TUESDAY, March 1, 2016 (HealthDay News) -- Plasma uric acid (PUA) levels are significantly lower in adolescent patients with type 1 diabetes (T1D) than in healthy control subjects, and there does not appear to be a link between PUA levels and cardiorenal abnormalities in these patients, according to a study published online Feb. 19 in Diabetes Care.

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