Major Depressive Disorder Ups Acute MI Risk in HIV-Infected

This article originally appeared here.
Share this content:
Major Depressive Disorder Ups Acute MI Risk in HIV-Infected
Major Depressive Disorder Ups Acute MI Risk in HIV-Infected

FRIDAY, Aug. 26, 2016 (HealthDay News) -- For HIV-infected adults, major depressive disorder (MDD) is associated with an increased risk of acute myocardial infarction (AMI), according to a study published online Aug. 24 in JAMA Cardiology.

Tasneem Khambaty, Ph.D., from the University of Miami in Coral Gables, and colleagues examined whether depressive disorders are associated with incident AMI in a cohort of 26,144 HIV-infected veterans with cardiovascular disease (CVD). At baseline, 19 percent of veterans had MDD and 9 percent had dysthymic disorder.

The researchers found that there were 490 AMI events (1.9 percent) during 5.8 years of follow-up. After adjustment for demographics, CVD risk factors, and HIV-specific factors, baseline MDD correlated with incident AMI (hazard ratios, 1.31 [95 percent confidence interval (CI), 1.05 to 1.62], 1.29 [95 percent CI, 1.04 to 1.60], and 1.30 [95 percent CI, 1.05 to 1.62], respectively). The associations were attenuated after further adjustment for hepatitis C, renal disease, substance abuse, and hemoglobin level (hazard ratio, 1.25; 95 percent CI, 1.00 to 1.56) and antidepressant use (hazard ratio, 1.12; 95 percent CI, 0.87 to 1.42). There was no correlation for baseline dysthymic disorder with incident AMI.

"Our findings raise the possibility that MDD may be independently associated with incident atherosclerotic CVD in the HIV-infected population," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Illicit Marijuana Use Up in States With Legal Medical Use

Illicit Marijuana Use Up in States With Legal ...

Cannabis use disorder is also rising faster in states with legalization laws

Chromosome Instability Test Prognostic in NSCLC

Chromosome Instability Test Prognostic in NSCLC

Chromosome instability associated with higher risk of relapse, death within 2 years

CDC: Opioid-Related Mortality Rate Might Be Underestimated

CDC: Opioid-Related Mortality Rate Might Be Underestimated

Death certificates from drug-linked infections may not label opioids as possible cause

is free, fast, and customized just for you!

Already a member?

Sign In Now »