Macrolide Antibiotics Not Linked to Ventricular Arrhythmia

This article originally appeared here.
Share this content:
Macrolide Antibiotics Not Linked to Ventricular Arrhythmia
Macrolide Antibiotics Not Linked to Ventricular Arrhythmia

WEDNESDAY, Feb. 24, 2016 (HealthDay News) -- For older adults, macrolide antibiotics are not associated with a higher risk of ventricular arrhythmia within 30 days compared with nonmacrolide antibiotics, according to a study published online Feb. 22 in CMAJ, the journal of the Canadian Medical Association.

Mai H. Trac, from Western University in London, Canada, and colleagues conducted a population-based retrospective cohort study involving adults aged older than 65 years with a new prescription for an oral macrolide antibiotic in Ontario, Canada, from 2002 to 2013. Using propensity scores, patients were matched in a 1:1 ratio to controls prescribed nonmacrolide antibiotics. The analyses were repeated in four subgroups defined by the presence or absence of chronic kidney disease, congestive heart failure, coronary artery disease, and concurrent use of a drug known to prolong QT interval.

The researchers found that macrolide antibiotics were not associated with a higher risk of ventricular arrhythmia compared with nonmacrolide antibiotics (0.03 versus 0.03 percent; relative risk, 1.06; 95 percent confidence interval, 0.83 to 1.36). However, macrolide antibiotics were associated with a lower risk of 30-day all-cause mortality (0.62 versus 0.76 percent; relative risk, 0.82; 95 percent confidence interval, 0.78 to 0.86). Similar correlations were seen in all subgroups.

"These findings suggest that current warnings from the U.S. Food and Drug Administration may be overstated," the authors write.

One author's institution received unrestricted research funding from Pfizer.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Dupilumab Reduces Rate of Severe Asthma Exacerbations

Dupilumab Reduces Rate of Severe Asthma Exacerbations

And, add-on dupilumab reduces glucocorticoid dose in patients with glucocorticoid-treated asthma

Better Social Support Network Protects Black Men Against HIV

Better Social Support Network Protects Black Men Against ...

Social networks of black men who have sex with men influence HIV risk behavior

Recommendations Developed for Managing Postpartum Pain

Recommendations Developed for Managing Postpartum Pain

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

is free, fast, and customized just for you!

Already a member?

Sign In Now »