M-CSF Plays Role in Host Defense in Bacterial Pneumonia

This article originally appeared here.
Share this content:
M-CSF Plays Role in Host Defense in Bacterial Pneumonia
M-CSF Plays Role in Host Defense in Bacterial Pneumonia

THURSDAY, Aug. 4, 2016 (HealthDay News) -- The cytokine M-CSF promotes survival of lung and liver mononuclear phagocytes to mediate host defense during bacterial pneumonia, according to an experimental study published in the June 15 issue of The Journal of Immunology.

Noting that M-CSF has multiple effects on mononuclear phagocytes, Alexandra Bettina, from the University of Virginia in Charlottesville, and colleagues examined the role of M-CSF during bacterial pneumonia in a murine model.

The researchers observed reduced survival, increased bacterial burden, and greater lung injury with genetic deletion or immunoneutralization of M-CSF. M-CSF was also essential for lung mononuclear phagocyte expansion during infection, but had no effect on the number of bone marrow or blood monocytes, precursor proliferation, or leukocyte recruitment to the lungs. However, during pneumonia, M-CSF was necessary for survival and antimicrobial functions of lung and liver mononuclear phagocytes; bacterial dissemination to the liver and hepatic necrosis were seen in its absence.

"We conclude that M-CSF is critical to host defenses against bacterial pneumonia by mediating survival and antimicrobial functions of mononuclear phagocytes in the lungs and liver," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Brief Bouts of Exercise Can Reduce Inflammation

Brief Bouts of Exercise Can Reduce Inflammation

20 minutes on a treadmill linked to drop in immune cells tied to inflammation

Dementia May Be Exacerbated by Hospital-Related Delirium

Dementia May Be Exacerbated by Hospital-Related Delirium

Researchers say efforts must be increased to diagnose, prevent, and treat delirium

Oxytocin Ups Feeding, Social Skills in Infants With Prader-Willi

Oxytocin Ups Feeding, Social Skills in Infants With ...

Significant decrease in Neonatal Oral-Motor Scale scores, videofluoroscopy of swallowing after therapy

is free, fast, and customized just for you!

Already a member?

Sign In Now »