M-CSF Plays Role in Host Defense in Bacterial Pneumonia

This article originally appeared here.
Share this content:
M-CSF Plays Role in Host Defense in Bacterial Pneumonia
M-CSF Plays Role in Host Defense in Bacterial Pneumonia

THURSDAY, Aug. 4, 2016 (HealthDay News) -- The cytokine M-CSF promotes survival of lung and liver mononuclear phagocytes to mediate host defense during bacterial pneumonia, according to an experimental study published in the June 15 issue of The Journal of Immunology.

Noting that M-CSF has multiple effects on mononuclear phagocytes, Alexandra Bettina, from the University of Virginia in Charlottesville, and colleagues examined the role of M-CSF during bacterial pneumonia in a murine model.

The researchers observed reduced survival, increased bacterial burden, and greater lung injury with genetic deletion or immunoneutralization of M-CSF. M-CSF was also essential for lung mononuclear phagocyte expansion during infection, but had no effect on the number of bone marrow or blood monocytes, precursor proliferation, or leukocyte recruitment to the lungs. However, during pneumonia, M-CSF was necessary for survival and antimicrobial functions of lung and liver mononuclear phagocytes; bacterial dissemination to the liver and hepatic necrosis were seen in its absence.

"We conclude that M-CSF is critical to host defenses against bacterial pneumonia by mediating survival and antimicrobial functions of mononuclear phagocytes in the lungs and liver," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

FDA Approves New Parkinson's Add-On Drug Xadago

FDA Approves New Parkinson's Add-On Drug Xadago

To help prevent 'off' episodes among users of levodopa/carbidopa

Infant Mortality Down in United States From 2005 to 2014

Infant Mortality Down in United States From 2005 ...

Largest decreases seen for infants of Asian or Pacific Islander and non-Hispanic black women

Intensive Strategy Addresses Hypoxemia After Cardiac Surgery

Intensive Strategy Addresses Hypoxemia After Cardiac Surgery

Intensive alveolar recruitment strategy linked to less severe pulmonary complications after cardiac sx

is free, fast, and customized just for you!

Already a member?

Sign In Now »