LVEF Improvement for Many With Primary Prevention ICDs

Share this content:
LVEF Improvement for Many With Primary Prevention ICDs
LVEF Improvement for Many With Primary Prevention ICDs

THURSDAY, July 30, 2015 (HealthDay News) -- Forty percent of patients with primary prevention implantable cardioverter-defibrillators (ICDs) experience improvement in left ventricular ejection fraction (LVEF), according to a study published in the Aug. 4 issue of the Journal of the American College of Cardiology.

Yiyi Zhang, Ph.D., from the Johns Hopkins University Bloomberg School of Public Health in Baltimore, and colleagues conducted a prospective cohort study involving 538 patients with repeated LVEF assessments after ICD implantation for primary prevention of sudden cardiac death. Participants were followed for a mean of 4.9 years.

The researchers found that LVEF decreased in 13.0 percent of patients, improved in 40.0 percent, and was unchanged in 47.0 percent during follow-up. For patients with versus without improved LVEF, the hazard ratios were 0.33 and 0.29 for mortality and appropriate shock, respectively. One-quarter of patients showed improvement in LVEF to >35 percent during follow-up, and there was a decrease in, but not elimination of, their risk of appropriate shock.

"Among primary prevention ICD patients, 40.0 percent had an improved LVEF during follow-up and 25 percent had LVEF improved to >35 percent," the authors write. "Changes in LVEF were inversely associated with all-cause mortality and appropriate shocks for ventricular tachyarrhythmias."

Several authors disclosed financial ties to the medical technology industry.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Improved achievement of glycemic targets, reduced body weight

European, American Guidelines Lead to Different Recs for Statins

European, American Guidelines Lead to Different Recs for ...

Quantification of CAC score can improve stratification for those at high, low risk for events

Hyperbaric O2 Therapy Effective in Maxillary Osteoradionecrosis

Hyperbaric O<sub>2</sub> Therapy Effective in Maxillary Osteoradionecrosis

Positive clinical outcome with HBOT for 85.7 percent of patients with maxillary bone osteoradionecrosis

is free, fast, and customized just for you!

Already a member?

Sign In Now »