Low Vitamin D Status Linked to Accelerated Cognitive Decline

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Low Vitamin D Status Linked to Accelerated Cognitive Decline
Low Vitamin D Status Linked to Accelerated Cognitive Decline

MONDAY, Sept. 14, 2015 (HealthDay News) -- For ethnically diverse older adults, low vitamin D status is associated with accelerated decline in cognitive function, according to a study published online Sept. 14 in JAMA Neurology.

Joshua W. Miller, Ph.D., from Rutgers University in New Brunswick, New Jersey, and colleagues examined the correlation between vitamin D status and trajectories of change in subdomains of cognitive function in a cohort of 382 ethnically diverse older adults (41.4 percent white, 29.6 percent African-American, 25.1 percent Hispanic, and 3.9 percent other race/ethnicity).

The researchers found that the mean 25-hydroxyvitamin D (25-OHD) level was 19.2 ng/mL; 26.2 and 35.1 percent of participants were vitamin D deficient and insufficient, respectively. Compared with white participants, the mean 25-OHD levels were significantly lower for African-American and Hispanic participants (21.7 versus 17.9 and 17.2 ng/mL, respectively). The dementia group had significantly lower mean 25-OHD compared with the mild cognitive impairment and cognitively normal groups, respectively (16.2 versus 20 and 19.7 ng/mL, respectively). Vitamin D deficient and insufficient participants had greater rates of decline in episodic memory and executive function (vitamin D deficient: P = 0.49 and P = 0.01; vitamin D insufficient: P < 0.001 and P = 0.008) compared with those with adequate status, after adjustment for confounding variables.

"It remains to be determined whether vitamin D supplementation slows cognitive decline," the authors write.

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