Low Tumor Growth Rates During Active Surveillance of Thyroid CA

Share this content:
Low Tumor Growth Rates During Active Surveillance of Thyroid CA
Low Tumor Growth Rates During Active Surveillance of Thyroid CA

FRIDAY, Sept. 1, 2017 (HealthDay News) -- Among patients with low-risk papillary thyroid cancer (PTC), the rates of tumor growth during active surveillance are low, according to a study published online Aug. 31 in JAMA Otolaryngology-Head & Neck Surgery.

R. Michael Tuttle, M.D., from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues describe the kinetics of PTC tumor growth during active surveillance in a cohort of 291 patients undergoing active surveillance for low-risk PTC.

The researchers found that growth in tumor diameter of 3 mm or more occurred in 3.8 percent of patients, with a cumulative incidence of 2.5 and 12.1 percent at two and five years, respectively. During active surveillance, no regional or distant metastases developed. Three-dimensional measurements of tumor volume allowed for earlier identification of growth in all cases (median, 8.2 months before increase in tumor diameter). Younger age at diagnosis (hazard ratio per year, 0.92) and risk category at presentation (hazard ratio for inappropriate, 55.17) correlated independently with the likelihood of tumor growth. Kinetics demonstrated a classic exponential growth pattern among tumors experiencing volume growth, with a median doubling time of 2.2 years.

"Serial measurement of tumor volumes may facilitate early identification of tumors that will continue to grow and thereby inform the timing of surveillance imaging and therapeutic interventions," the authors write.

Abstract/Full Text
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Opioid Rx, Dosing Often Excessive in Dialysis Patients

Opioid Rx, Dosing Often Excessive in Dialysis Patients

High-risk dialysis population also subject to the risks of long-term opioid use

Nonadherence to Statins  ACEIs/ARBs Risky Post MI

Nonadherence to Statins + ACEIs/ARBs Risky Post MI

Adherence to beta-blockers may not be as beneficial to patients after myocardial infarction

Pulse Ox  Auscultation Reliable for Congenital Heart Screening

Pulse Ox + Auscultation Reliable for Congenital Heart ...

The method significantly improves detection rate of major CHD in newborns

is free, fast, and customized just for you!

Already a member?

Sign In Now »