Low Serum Levels of DHEAS Predict Fractures in Older Men

This article originally appeared here.
Share this content:
Low Serum Levels of DHEAS Predict Fractures in Older Men
Low Serum Levels of DHEAS Predict Fractures in Older Men

WEDNESDAY, March 22, 2017 (HealthDay News) -- For older men, low serum levels of the adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are a risk marker for fractures, according to a study published online March 9 in the Journal of Bone and Mineral Research.

Claes Ohlsson, M.D., Ph.D., from the University of Gothenburg in Sweden, and colleagues analyzed serum DHEAS levels with mass spectrometry for 2,568 participants (age 69 to 81 years) from the population-based Osteoporotic Fractures in Men study in Sweden.

The researchers ascertained a total of 594 incident X-ray-validated fractures during a median follow-up of 10.6 years. After adjustment for age, body mass index, and prevalent fractures, there was an inverse association between DHEAS levels with the risk of any fracture (hazard ratio per standard deviation decrease, 1.14; 95 percent confidence interval, 1.05 to 1.24), non-vertebral major osteoporotic fractures (hazard ratio, 1.31; 95 percent confidence interval, 1.16 to 1.48), and hip fractures (hazard ratio, 1.18; 95 percent confidence interval, 1.02 to 1.37), but not with clinical vertebral fractures (hazard ratio, 1.09; 95 percent confidence interval, 0.95 to 1.26). The associations were slightly attenuated after further adjustment for traditional risk factors for fracture, bone mineral density, and/or physical performance variables.

"In conclusion, low serum DHEAS levels are a risk marker of mainly non-vertebral fractures in older men, of whom those with DHEAS levels below 0.60 µg/ml are at highest risk," the authors write.

The study was partially funded by the Novo Nordisk Foundation.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

FDA OKs Drug for Hemophilia A With Factor VIII Inhibitors

FDA OKs Drug for Hemophilia A With Factor ...

Weekly prophylactic treatment associated with substantial decrease in bleeding episodes

Risk of Falls Up With Mild, Moderate Diabetic Retinopathy

Risk of Falls Up With Mild, Moderate Diabetic ...

And perceived barriers to diabetes self-management are associated with severity of diabetic retinopathy

AMD Risk Has Dropped By Birth Cohort Throughout 20th Century

AMD Risk Has Dropped By Birth Cohort Throughout ...

Generational association remains significant after adjustment for age, sex, other confounders

is free, fast, and customized just for you!

Already a member?

Sign In Now »