Low-Dose Chlorthalidone Beats HCTZ for Ambulatory BP Control

Share this content:
Low-Dose Chlorthalidone Beats HCTZ for Ambulatory BP Control
Low-Dose Chlorthalidone Beats HCTZ for Ambulatory BP Control

WEDNESDAY, Jan. 27, 2016 (HealthDay News) -- For patients with stage 1 hypertension, low-dose chlorthalidone is associated with reduction in ambulatory blood pressure (ABP), while low-dose hydrochlorothiazide (HCTZ) may result in masked hypertension, according to a study published in the Feb. 2 issue of the Journal of the American College of Cardiology.

Anil K. Pareek, M.D., from Ipca Laboratories Limited in Mumbai, India, and colleagues compared 6.25 mg daily chlorthalidone with 12.5 mg daily HCTZ via ABP monitoring in a 12-week trial. Fifty-four patients with stage 1 hypertension were randomized to chlorthalidone, HCTZ 12.5 mg, or HCTZ-controlled release (CR) 12.5 mg (16, 18, and 20 patients, respectively). ABP monitoring was conducted at baseline and after four and 12 weeks of treatment.

The researchers found that office BP was lower at weeks four and 12 from baseline with all three treatments (P < 0.01). With chlorthalidone, but not HCTZ, there were significant reductions in systolic and diastolic 24-hour ambulatory and nighttime BP at weeks four and 12 (P < 0.01). Nighttime systolic ABP was significantly lower with chlorthalidone versus HCTZ at weeks four (P = 0.015) and 12 (P = 0.020). Sustained hypertension was converted into masked hypertension with HCTZ therapy. The HCTZ-CR group showed a significant reduction in 24-hour ABP compared with HCTZ (P < 0.01).

"Treatment with low-dose chlorthalidone, 6.25 mg daily, significantly reduced mean 24-hour ABP as well as daytime and nighttime BP. Due to its short duration of action, no significant 24-hour ABP reduction was seen with HCTZ, 12.5 mg daily, which merely converted sustained hypertension into masked hypertension," the authors write. "Low-dose chlorthalidone, 6.25 mg, could be used as monotherapy for treatment of essential hypertension, whereas low-dose HCTZ monotherapy is not an appropriate antihypertensive drug."

Several authors are employees of Ipca Laboratories, which supported the study. One author disclosed financial ties to pharmaceutical companies, including Ipca Laboratories.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »