Longer Progression-Free Survival for Durvalumab in NSCLC

This article originally appeared here.
Share this content:
Longer Progression-Free Survival for Durvalumab in NSCLC
Longer Progression-Free Survival for Durvalumab in NSCLC

MONDAY, Sept. 11, 2017 (HealthDay News) -- For patients with locally advanced, unresectable, non-small-cell lung cancer (NSCLC), the anti-programmed death ligand 1 antibody durvalumab is associated with significantly longer progression-free survival compared with placebo, according to a study published online Sept. 8 in the New England Journal of Medicine. The research was published to coincide with the European Society of Medical Oncology Congress, held from Sept. 8 to 12 in Madrid.

Scott J. Antonia, M.D., Ph.D., from the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Fla., and colleagues randomized 709 patients with stage III NSCLC in a 2:1 ratio to receive durvalumab (473 patients) or placebo (236 patients) every two weeks for up to one year.

The researchers found that the median progression-free survival from randomization was 16.8 and 5.6 months for durvalumab and placebo, respectively (stratified hazard ratio for disease progression or death, 0.52); the 12- and 18-month progression-free survival rates were 55.9 and 35.3 percent, respectively, and 44.2 and 27.0 percent, respectively. A significantly higher response rate was seen with durvalumab versus placebo (28.4 versus 16.0 percent), with a longer median duration of response (72.8 versus 46.8 percent of patients had ongoing response at 18 months). Durvalumab was associated with significantly longer median time to death or distant metastasis (23.2 versus 14.6 months). Grade 3 or 4 adverse events occurred in 29.9 and 26.1 percent of patients who received durvalumab and placebo, respectively.

"Progression-free survival was significantly longer with durvalumab than with placebo," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including AstraZeneca, which manufactures durvalumab and funded the study.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality ...

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination ...

Pharmacies can address cost barriers to vaccination by providing vaccines at lower cost

Single Blood Sample Test May Help ID Undiagnosed Diabetes

Single Blood Sample Test May Help ID Undiagnosed ...

Single-sample confirmatory definition associated with high positive predictive value

is free, fast, and customized just for you!




Already a member?

Sign In Now »