Lixisenatide Beneficial in Seniors With Uncontrolled Diabetes

Share this content:
Lixisenatide Beneficial in Seniors With Uncontrolled Diabetes
Lixisenatide Beneficial in Seniors With Uncontrolled Diabetes

WEDNESDAY, Feb. 15, 2017 (HealthDay News) -- Lixisenatide is more effective than placebo for older patients with uncontrolled diabetes on their current medication, with no unexpected safety findings, according to a study published online Feb. 10 in Diabetes Care.

Graydon S. Meneilly, M.D., from the University of British Columbia in Vancouver, Canada, and colleagues conducted a phase III trial involving 350 patients aged ≥70 years who were randomized to once-daily lixisenatide or placebo before breakfast concomitantly with their existing medication (including insulin) for 24 weeks. The absolute change in hemoglobin A1c (HbA1c) was assessed from baseline to week 24 as the primary end point.

The researchers found that, from baseline to week 24, there was a significant decrease in HbA1c with lixisenatide versus placebo (−0.57 versus +0.06 percent; P < 0.0001). Lixisenatide correlated with a significantly greater mean reduction in two-hour postprandial plasma glucose versus placebo (−5.12 versus −0.07 mmol/L; P < 0.0001). There was also a significantly greater decrease in body weight with lixisenatide versus placebo (−1.47 versus −0.16 kg; P < 0.0001). The safety profile of lixisenatide in this population was consistent with that seen in other studies, including rates of nausea and vomiting. Hypoglycemia was reported in 17.6 and 10.3 percent of patients taking lixisenatide and placebo, respectively.

"In non-frail older patients uncontrolled on their current antidiabetic treatment, lixisenatide was superior to placebo in HbA1c reduction and in targeting postprandial hyperglycemia, with no unexpected safety findings," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Sanofi, which manufactures lixisenatide and funded the trial.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »