Liraglutide Tops Lixisenatide As Add-On to Metformin in T2DM

Share this content:
Liraglutide Tops Lixisenatide As Add-On to Metformin in T2DM
Liraglutide Tops Lixisenatide As Add-On to Metformin in T2DM

MONDAY, June 27, 2016 (HealthDay News) -- For patients with type 2 diabetes taking metformin, add-on liraglutide is more effective than lixisenatide for improving glycemic control, according to a study published online June 16 in Diabetes Care.

Michael Nauck, M.D., from the Ruhr-University Bochum in Germany, and colleagues conducted a 26-week randomized trial involving 404 patients with type 2 diabetes not achieving adequate glycemic control on metformin alone. Participants were randomized in a 1:1 ratio to liraglutide (administered once daily at any time of the day) or lixisenatide (administered once daily within one hour prior to morning or evening meal).

The researchers found that hemoglobin A1c (HbA1c) was reduced more with liraglutide than lixisenatide at week 26 (estimated treatment difference −0.62 percent; P < 0.0001), with more patients reaching HbA1c <7 percent and ≤6.5 percent (both P < 0.0001). Liraglutide correlated with a greater reduction in fasting plasma glucose (estimated treatment difference, −1.15 mmol/L; P < 0.0001). There was a greater reduction in mean nine-point self-measured plasma glucose with liraglutide (P < 0.0001). Similar body weight decreases were seen for both drugs (−4.3 kg for liraglutide and −3.7 kg for lixisenatide; P = 0.23).

"At the dose levels studied, liraglutide was more effective than lixisenatide as add-on to metformin in improving glycemic control," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Novo Nordisk, which manufactures liraglutide and funded the study.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Diagnosis of Infantile Spasms Too Often Delayed

Diagnosis of Infantile Spasms Too Often Delayed

Parents, doctors may not recognize infantile spasms early enough to prevent brain damage

Patient Mortality Up With End-of-Rotation Team Transition

Patient Mortality Up With End-of-Rotation Team Transition

Adherence to national recommendations regarding ideal rotation policies ranged from 6 to 67 percent

Pubic Hair Grooming Tied to Heightened Risk of STIs

Pubic Hair Grooming Tied to Heightened Risk of ...

Researchers find extreme groomers have four-fold risk of contracting sexually transmitted infection

is free, fast, and customized just for you!

Already a member?

Sign In Now »