Liraglutide May Blunt Impact of Exercise in Dysregulated T2DM

Share this content:
Liraglutide May Blunt Impact of Exercise in Dysregulated T2DM
Liraglutide May Blunt Impact of Exercise in Dysregulated T2DM

THURSDAY, Feb. 16, 2017 (HealthDay News) -- For individuals with dysregulated type 2 diabetes, the addition of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide may attenuate the impact of exercise, according to a study published online Feb. 11 in Diabetes, Obesity and Metabolism.

Peter G. Jørgensen, from the University of Copenhagen in Denmark, and colleagues examined cardiac function before and after 16 weeks of GLP-1RA liraglutide treatment or placebo combined with supervised exercise among 33 dysregulated patients with type 2 diabetes treated with diet and/or metformin.

The researchers found that early diastolic myocardial tissue velocity improved with exercise in the placebo group (−7.1 ± 1.6 to −7.7 ± 1.8 cm/s; P = 0.01), but no improvement was seen in the liraglutide group (−7.1 ± 1.4 to −7.0 ± 1.4 cm/s; P = 0.60) (between-group difference, P = 0.02). There was improvement in the ratio of early and atrial mitral annular tissue velocities in the placebo group (1.0 ± 0.4 to 1.2 ± 0.4; P = 0.003), but no improvement in the liraglutide group (1.0 ± 0.3 to 1.0 ± 0.3; P = 0.87) (between-group difference, P = 0.03). Heart rate and left ventricular structure or function did not differ significantly within or between the groups.

"Addition of liraglutide to exercise in sedentary patients with dysregulated type 2 diabetes may blunt the suggested beneficial effect of exercise on left ventricular diastolic function," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Novo Nordisk, which funded the study and sponsored the liraglutide and placebo pens.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC Issues Warning on Contaminated Raw Milk

CDC Issues Warning on Contaminated Raw Milk

Case of New Jersey woman becoming ill after drinking raw milk from Udder Milk company

Cerebral Morphometric Changes Discriminate ADHD, Controls

Cerebral Morphometric Changes Discriminate ADHD, Controls

Alterations discern ADHD-I, ADHD-C, with discriminating features located in DMN, insular cortex

Baby Boomers Have Increased Risk of Rx Opioid Overdose Death

Baby Boomers Have Increased Risk of Rx Opioid ...

In addition, those born from 1947 to 1964 and 1979 to 1992 have increased risk of heroin overdose death

is free, fast, and customized just for you!

Already a member?

Sign In Now »