Liraglutide Is Not Justified for All Patients With T1DM

This article originally appeared here.
Share this content:
Liraglutide Is Not Justified for All Patients With T1DM
Liraglutide Is Not Justified for All Patients With T1DM

FRIDAY, April 8, 2016 (HealthDay News) -- For patients with type 1 diabetes mellitus (T1DM), addition of 1.2 and 1.8 mg of liraglutide to insulin over a 12-week period is associated with a modest reduction in weekly mean glucose levels, according to a study published online April 5 in Diabetes Care.

Nitesh D. Kuhadiya, M.D., M.P.H., from State University of New York at Buffalo, and colleagues randomized 72 patients with T1DM to receive placebo (18 patients) and 0.6, 1.2, and 1.8 mg of liraglutide (54 patients) daily for 12 weeks.

The researchers observed a significant mean weekly reduction in average blood glucose in the 1.2- and 1.8-mg groups (P < 0.0001); the average blood glucose remained unchanged in the 0.6-mg and placebo groups. Hemoglobin A1c was reduced significantly in the 1.2-mg group (P < 0.01), but not in the 1.8- or 0.6-mg groups compared with placebo. In the 1.2-mg group only, glycemic variability was significantly reduced (P < 0.01). In the 1.2-mg and 1.8-mg groups, total daily insulin dose decreased significantly (P < 0.05). Weight loss was 5 ± 1 kg in the 1.2- and 1.8-mg groups (P < 0.05) and 2.7 ± 0.6 kg (P < 0.01) in the 0.6-mg group, compared with none in the placebo group. Higher gastrointestinal adverse events were seen with liraglutide (P < 0.05).

"These findings do not justify the use of liraglutide in all patients with type 1 diabetes," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Novo Nordisk, which manufactures liraglutide and funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Improved achievement of glycemic targets, reduced body weight

European, American Guidelines Lead to Different Recs for Statins

European, American Guidelines Lead to Different Recs for ...

Quantification of CAC score can improve stratification for those at high, low risk for events

Hyperbaric O2 Therapy Effective in Maxillary Osteoradionecrosis

Hyperbaric O<sub>2</sub> Therapy Effective in Maxillary Osteoradionecrosis

Positive clinical outcome with HBOT for 85.7 percent of patients with maxillary bone osteoradionecrosis

is free, fast, and customized just for you!

Already a member?

Sign In Now »