Liraglutide Doesn't Affect Gastric Emptying in Type 1 Diabetes

Share this content:
Liraglutide Doesn't Affect Gastric Emptying in Type 1 Diabetes
Liraglutide Doesn't Affect Gastric Emptying in Type 1 Diabetes

MONDAY, Nov. 28, 2016 (HealthDay News) -- For individuals with type 1 diabetes mellitus (T1DM), liraglutide therapy does not affect the rate of gastric emptying (GE) during hypoglycemia, according to a study published online Nov. 21 in Diabetes, Obesity and Metabolism.

Christian Seerup Frandsen, M.D., from the University of Copenhagen in Denmark, and colleagues examined the effect of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide on counterregulatory responses and GE rate during hypoglycemia in individuals with T1DM in a 12-week randomized trial. Twenty patients aged older than 18 years and with glycated hemoglobin ≥8 percent were randomized to liraglutide once daily or placebo as add-on to insulin treatment. A hypoglycemic clamp was carried out followed by a liquid meal before and at the end of treatment.

The researchers observed no significant between-group differences in the changes in GE rates after 12 weeks of treatment (P = 0.96); no significant changes were seen from baseline whether assessed by area under the acetaminophen curve or time to peak. Similar between-group results were seen in secondary end points, including glycemic recovery, counterregulatory hormone responses, systolic blood pressure, and GLP-1 and pancreatic polypeptide responses. There was an increase in heart rate with liraglutide (69 ± 4 to 80 ± 5 beats/min; P = 0.02).

"Liraglutide does not compromise glycemic recovery, GE rate, or counterregulatory hormone responses in type 1 diabetes during hypoglycemia," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Novo Nordisk, which funded the study.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Walmart Launches Disposal Solution for Opioids, Rx Meds

Walmart Launches Disposal Solution for Opioids, Rx Meds

DisposeRx, available at no cost, transforms prescription drugs into non-divertible, biodegradable gel

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

ADHD Meds Increasingly Prescribed to Reproductive-Aged Women

Increase of 344 percent, from 0.9 percent of women in 2003 to 4 percent of women in 2015

Bikram Yoga Improves Vascular Health With or Without Heat

Bikram Yoga Improves Vascular Health With or Without ...

Increase in brachial artery flow-mediated dilation seen in heated and thermoneutral environment

is free, fast, and customized just for you!

Already a member?

Sign In Now »