'Liquid Biopsy' Shows Promise for Hepatocellular Carcinoma

Share this content:
'Liquid Biopsy' Shows Promise for Hepatocellular Carcinoma
'Liquid Biopsy' Shows Promise for Hepatocellular Carcinoma

TUESDAY, Oct. 17, 2017 (HealthDay News) -- 'Liquid biopsy' technology holds promise for diagnosing, monitoring, and predicting prognosis in patients with hepatocellular carcinoma (HCC), according to a study published online Oct. 9 in Nature Materials.

Rui-hua Xu, from State Key Laboratory of Oncology in China, and colleagues compared HCC tissue and normal blood leukocytes from circulating tumor (ctDNA) samples from a cohort of 1,098 HCC patients and 835 normal controls in order to identify an HCC-specific methylation marker panel.

The researchers found that methylation profiles of HCC tumor DNA and matched plasma ctDNA were highly correlated. They constructed a prediction model that showed high diagnostic specificity and sensitivity and was highly correlated with tumor burden, treatment response, and stage. They also constructed a prognostic prediction model that effectively predicted prognosis and survival.

"Together, these findings demonstrate in a large clinical cohort the utility of ctDNA methylation markers in the diagnosis, surveillance, and prognosis of HCC," conclude the authors.

Abstract/Full Text (subscription or payment may be required

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality ...

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination ...

Pharmacies can address cost barriers to vaccination by providing vaccines at lower cost

Single Blood Sample Test May Help ID Undiagnosed Diabetes

Single Blood Sample Test May Help ID Undiagnosed ...

Single-sample confirmatory definition associated with high positive predictive value

is free, fast, and customized just for you!




Already a member?

Sign In Now »