Lipoproteins, Lipids Have Similar Ties to MI, Ischemic Stroke

Share this content:
Lipoproteins, Lipids Have Similar Ties to MI, Ischemic Stroke
Lipoproteins, Lipids Have Similar Ties to MI, Ischemic Stroke

TUESDAY, Feb. 13, 2018 (HealthDay News) -- Lipoproteins and lipids are similarly associated with risk of myocardial infarction (MI) and ischemic stroke (IS) but not intracerebral hemorrhage (ICH), according to a study published in the Feb. 13 issue of the Journal of the American College of Cardiology.

Michael V. Holmes, M.D., Ph.D., from the University of Oxford in the United Kingdom, and colleagues evaluated the associations of plasma metabolic markers with risks of incident MI, IS, and ICH. Nuclear magnetic resonance spectroscopy was used to measure 225 metabolic markers in baseline plasma samples as part of a nested case-control study.

Based on samples from 912 MI, 1,146 IS, and 1,138 ICH cases, as well as 1,466 common control subjects, the researchers found that very low-, intermediate-, and low-density lipoprotein particles were positively associated with MI and IS. There was an inverse association between high-density lipoprotein (HDL) particles and MI apart from small HDL. No lipoprotein particles were associated with ICH. There was an inverse association between cholesterol in large HDL and MI and IS (odds ratio [OR], 0.79 and 0.88, respectively), while cholesterol in small HDL was not associated with MI and IS (OR, 0.99 and 1.06, respectively). Triglycerides within all lipoproteins were positively associated with MI and, similarly, IS.

"Lipoproteins and lipids showed similar associations with MI and IS, but not with ICH," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality ...

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination ...

Pharmacies can address cost barriers to vaccination by providing vaccines at lower cost

Single Blood Sample Test May Help ID Undiagnosed Diabetes

Single Blood Sample Test May Help ID Undiagnosed ...

Single-sample confirmatory definition associated with high positive predictive value

is free, fast, and customized just for you!




Already a member?

Sign In Now »