Lipophilic Superior to Hydrophilic Statin in Heart Failure

This article originally appeared here.
Share this content:
Lipophilic Superior to Hydrophilic Statin in Heart Failure
Lipophilic Superior to Hydrophilic Statin in Heart Failure

FRIDAY, Aug. 21, 2015 (HealthDay News) -- For patients with heart failure, treatment effects are superior with lipophilic versus hydrophilic statins, according to a meta-analysis published online Aug. 17 in Cardiovascular Therapeutics.

Kwadwo Osei Bonsu, from Monash University in Bandar Sunway, Malaysia, and colleagues conducted a meta-analysis to compare the treatment effects of lipophilic and hydrophilic statins on outcomes of established heart failure. Data were included for 6,214 patients from 19 randomized controlled trials.

The researchers found that lipophilic statin was superior to hydrophilic statin treatment for left ventricular ejection fraction (standardized mean difference [SMD], 4.54), B-type natriuretic peptide (SMD, −1.60), high-sensitivity C-reactive protein (SMD, −1.13), and interleukin-6 (SMD, −3.75) (all P < 0.001).

"Lipophilic statin produces greater treatment effects on cardiac function and inflammation compared with hydrophilic statin in patients with heart failure," the authors write. "Until data from [an] adequately powered head-to-head trial of the statin types are available, our meta-analysis brings clinicians and researchers a step closer to the quest on which statin -- lipophilic or hydrophilic -- is associated with better outcomes in heart failure."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

Non-Nutritive Sweeteners Don't Up Blood Glucose Levels

Non-Nutritive Sweeteners Don't Up Blood Glucose Levels

Concentration of NNSs decreases gradually over the course of observation after consumption

Laws Allowing Service Denial to Sexual Minorities Tied to Distress

Laws Allowing Service Denial to Sexual Minorities Tied ...

Laws permitting denial of services linked to increase in mental distress among sexual minorities

Antidepressant Prescribing Linked to Lasting Weight Gain

Antidepressant Prescribing Linked to Lasting Weight Gain

Risk of weight gain remained increased during at least six years of follow-up