Lipid-Rich Necrotic Core in Femoral Artery Ups PAD Events

Share this content:
Lipid-Rich Necrotic Core in Femoral Artery Ups PAD Events
Lipid-Rich Necrotic Core in Femoral Artery Ups PAD Events

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Lipid-rich necrotic core (LRNC) in the proximal superficial femoral artery (SFA) is associated with higher rates of peripheral artery disease (PAD) events, according to a study published online Nov. 9 in JACC: Cardiovascular Imaging.

Mary M. McDermott, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues followed patients with ankle brachial index (ABI) <1.00 annually to examine the correlation between the presence of LRNC in the SFA and PAD event rates. SFA atherosclerotic plaques were characterized at baseline using magnetic resonance imaging.

The researchers found that 24 percent of the 254 PAD participants had LRNC and 59 percent had calcium in the SFA at baseline. At 47-month follow-up, SFA LRNC was associated with increased incidence of the combined outcome of lower extremity amputation, critical limb ischemia, ABI decline of ≥0.15, and revascularization (hazard ratio, 2.18), after adjustment for age, sex, race, comorbidities, baseline ABI, and other confounding variables. Even when this combined outcome excluded lower extremity revascularization, the association of SFA LRNC with PAD events was maintained (hazard ratio, 2.58). There was no correlation for LRNC in the SFA with all-cause mortality, acute coronary events, or stroke.

"Among people with PAD, LRNC in the SFA was associated with higher rates of clinical PAD events and this association was independent of the ABI," the authors write.

Several authors disclosed financial ties to the health care and pharmaceutical industries.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Tai Chi Found to Be Beneficial for Veterans With PTSD

Tai Chi Found to Be Beneficial for Veterans ...

Chinese exercise regimen helps veterans cope with distressing symptoms of PTSD

Healthy Diet May Help Lengthen the Lives of CKD Patients

Healthy Diet May Help Lengthen the Lives of ...

Study found eating lots of fruit, vegetables, fish, whole grains was linked to lower rate of early death

Regular Cannabis Use May Affect Retinal Ganglion Cell Function

Regular Cannabis Use May Affect Retinal Ganglion Cell ...

May disrupt, delay signal transmitted along the visual pathway via the optic nerve

is free, fast, and customized just for you!

Already a member?

Sign In Now »