Lifestyle Intervention Before Infertility Treatment No Benefit

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Lifestyle Intervention Before Infertility Treatment No Benefit
Lifestyle Intervention Before Infertility Treatment No Benefit

FRIDAY, May 20, 2016 (HealthDay News) -- A lifestyle intervention preceding infertility treatment does not result in higher rates of vaginal birth among obese infertile women, according to a study published in the May 19 issue of the New England Journal of Medicine.

Meike A.Q. Mutsaerts, M.D., Ph.D., from the University of Groningen in the Netherlands, and colleagues randomized infertile women with a body mass index of 29 kg/m² or more to a six-month lifestyle intervention preceding 18 months of infertility treatment (289 women) or to a control group with immediate infertility treatment for 24 months (285 women).

The researchers found that the intervention group had a discontinuation rate of 21.8 percent. The mean weight loss was 4.4 kg and 1.1 kg in the intervention group and control groups, respectively, in intention-to-treat analyses (P < 0.001). The primary outcome of vaginal birth of a healthy singleton at term within 24 months occurred in 27.1 and 35.2 percent of the intervention and control groups, respectively (rate ratio in the intervention group, 0.77; 95 percent confidence interval, 0.60 to 0.99).

"In obese infertile women, a lifestyle intervention preceding infertility treatment, as compared with prompt infertility treatment, did not result in higher rates of a vaginal birth of a healthy singleton at term within 24 months after randomization," the authors write.

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