Levosimendan Doesn't Prevent Acute Organ Dysfunction

This article originally appeared here.
Share this content:
Levosimendan Doesn't Prevent Acute Organ Dysfunction
Levosimendan Doesn't Prevent Acute Organ Dysfunction

FRIDAY, Oct. 7, 2016 (HealthDay News) -- For adults with sepsis, levosimendan does not prevent acute organ dysfunction, according to a study published online Oct. 5 in the New England Journal of Medicine to coincide with the European Society of Intensive Care Medicine Annual Congress, held from Oct. 1 to 5 in Milan.

Anthony C. Gordon, M.D., from Charing Cross Hospital in London, and colleagues conducted a randomized trial involving adult patients with sepsis. In addition to standard care, patients were randomized to receive either a blinded infusion of levosimendan for 24 hours (259 patients) or placebo (257 patients).

The researchers found that the mean Sequential Organ Failure Assessment score did not differ significantly between the groups (mean difference, 0.61; P = 0.053). Mortality at 28 days was 34.5 and 30.9 percent in the levosimendan and placebo groups, respectively (P = 0.43). Among those requiring ventilation at baseline, the likelihood of being successfully weaned from mechanical ventilation over 28 days was lower in the levosimendan group (hazard ratio, 0.77; P = 0.03). Supraventricular tachyarrhythmia occurred in more patients in the levosimendan group (3.1 versus 0.4 percent; P = 0.04).

"The addition of levosimendan to standard treatment in adults with sepsis was not associated with less severe organ dysfunction or lower mortality," the authors write. "Levosimendan was associated with a lower likelihood of successful weaning from mechanical ventilation and a higher risk of supraventricular tachyarrhythmia."

Several authors disclosed financial ties to pharmaceutical companies, including Tenax, which developed levosimendan and provided funding for the study.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Many Health Care Providers Work While Sick

Many Health Care Providers Work While Sick

Pharmacists and physicians have the highest frequency of working with influenza-like illness

Simple Checklist Can Identify Useful Clinical Practice Guidelines

Simple Checklist Can Identify Useful Clinical Practice Guidelines

Eight-item tool developed for clinicians to identify trustworthy, useful, and relevant guidelines

is free, fast, and customized just for you!

Already a member?

Sign In Now »