Leukotriene B4 Is Promising Drug Target for Tx of Lymphedema

Share this content:
Leukotriene B<sub>4</sub> Is Promising Drug Target for Tx of Lymphedema
Leukotriene B4 Is Promising Drug Target for Tx of Lymphedema

THURSDAY, May 11, 2017 (HealthDay News) -- An underlying mechanism has been identified that could eventually lead to the first drug therapy for lymphedema, according to a study published online May 10 in Science Translational Medicine.

Stanley Rockson, M.D., a professor at the Stanford University School of Medicine in California, and colleagues aimed to get a clearer understanding of the molecular mechanisms that drive lymphedema. The researchers used lab mice induced to have a lymphedema-like condition.

The scientists found that ketoprofen prevented tissue injury and fluid build-up by blocking the protein leukotriene B4 (LTB4). The same protein was elevated in cell samples from lymphedema patients. Another drug called bestatin worked just as well. Bestatin is not approved in the United States, but it has been used for years in Japan as a cancer treatment. The advantage of the drug, Rockson told HealthDay, is that it has more selective action against LTB4 and fewer side effects than ketoprofen.

Based on the lab findings, a clinical trial testing bestatin against lymphedema is underway, Rockson said.

Eiger BioPharmaceuticals, based in Palo Alto, Calif., is funding that trial (and acquiring the drug from its Japanese manufacturer). Rockson and a colleague on the study are consultants to the company.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »