Leukemia Patients Who Survive Severe GVHD Often Fare Worse

Share this content:
Leukemia Patients Who Survive Severe GVHD Often Fare Worse
Leukemia Patients Who Survive Severe GVHD Often Fare Worse

MONDAY, Oct. 23, 2017 (HealthDay News) -- After hematopoietic stem cell transplantation (HSCT) for acute leukemia, patients who survive severe acute graft-versus-host disease (aGVHD) have a higher risk of developing extensive chronic GVHD (cGVHD) and a higher rate of non-relapse mortality compared with those who did not develop severe aGVHD, according to a study published online Oct. 13 in the Journal of Internal Medicine.

Olle Ringdén, M.D., Ph.D., from the Karolinska Institutet in Sweden, and colleagues analyzed the long-term outcome in patients with acute leukemia who survived for more than six months after HSCT. They compared 1,738 patients alive after severe aGVHD with 21,825 patients who did not develop severe aGVHD (controls).

The researchers found that patients with severe aGVHD had higher non-relapse mortality (NRM) and a higher rate of extensive cGVHD than the controls. While the probability of relapse was significantly lower in the severe aGVHD group, leukemia-free survival (LFS) and overall survival were also significantly lower compared with the controls. For patients with severe aGVHD, five-year LFS was 49 percent versus 61 percent in controls with no or mild GVHD and 59 percent in patients with moderate GVHD.

"This study is a platform for outcome analysis in patients treated with novel therapies for acute GVHD," write the authors.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »