June 2017 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for June 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Poll Finds Seniors Struggling With Drug Costs Don't Seek Help

FRIDAY, June 30, 2017 (HealthDay News) -- Many older Americans who have difficulty paying for their medications don't seek help in finding more economical options, according to the University of Michigan National Poll on Healthy Aging.

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T1DM Patients With Active β-Cell Function Differ Immunologically

FRIDAY, June 30, 2017 (HealthDay News) -- Patients with remaining endogenous β-cell function after a decade of living with type 1 diabetes tend to have much higher levels of interleukin-35 (IL-35) than other patients with long-standing type 1 diabetes, according to a study published in the June issue of Diabetes Care.

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Genetic, Environmental Exposure Tied to Islet Autoantibodies

FRIDAY, June 30, 2017 (HealthDay News) -- For children, genetic factors and environmental exposures are associated with islet autoantibodies, according to a study published online June 23 in Diabetes Care.

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Review Links Flaxseed Consumption to Weight Reduction

THURSDAY, June 29, 2017 (HealthDay News) -- Whole flaxseed consumption is associated with significant reductions in body weight, body mass index (BMI), and waist circumference, according to a review published online June 21 in Obesity Reviews.

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Health of the Nation Presented in 40th Annual CDC Report

THURSDAY, June 29, 2017 (HealthDay News) -- The health of the United States is summarized in the 40th annual report published by the U.S. Centers for Disease Control and Prevention.

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Doctors Urged to Take Care With Electronic Communications

THURSDAY, June 29, 2017 (HealthDay News) -- Care should be taken when conveying electronic messages to patients, according to a report published by the American Medical Association (AMA).

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Tryptophan May Be Marker for Diabetic Nephropathy

THURSDAY, June 29, 2017 (HealthDay News) -- For patients with diabetes and chronic kidney disease (CKD), a lower level of tryptophan (Trp) is associated with rapid decline in estimated glomerular filtration rate (eGFR), according to a study published online June 26 in the Journal of Diabetes Investigation.

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FDA Seeks to Increase Number of Generic Drugs on Market

WEDNESDAY, June 28, 2017 (HealthDay News) -- New measures to increase the number of generic prescription drugs available to Americans have been taken by the U.S. Food and Drug Administration.

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Mixed Results on Acupuncture for Incontinence, Infertility

WEDNESDAY, June 28, 2017 (HealthDay News) -- Acupuncture received mixed reviews in two new studies -- one focusing on stress incontinence and the other on polycystic ovary syndrome-related infertility. The research was published in the June 27 issue of the Journal of the American Medical Association.

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Empagliflozin Ups β Cell Function in Impaired Fasting Glucose

WEDNESDAY, June 28, 2017 (HealthDay News) -- Empagliflozin is associated with improved beta cell function in subjects with impaired fasting glucose (IFG), according to a study published online June 13 in Diabetes.

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Estimated Prevalence of Diabetes 10.9 Percent in China

TUESDAY, June 27, 2017 (HealthDay News) -- The prevalence of diabetes is 10.9 percent in China, but only 36.5 percent of those with diabetes are aware of their diagnosis, according to research published online June 27 in the Journal of the American Medical Association.

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Intervention Ups Appropriate Dysglycemia Screening

TUESDAY, June 27, 2017 (HealthDay News) -- Implementation of an intervention, including electronic health record (EHR)-based decision support and training for use of the American Diabetes Association guidelines for dysglycemia screening, is associated with an increase in appropriate dysglycemia screening, according to a study published online June 15 in Diabetes Care.

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Review Spotlights Optimal Care of T2DM + Osteoporosis

MONDAY, June 26, 2017 (HealthDay News) -- Optimal management of coexisting type 2 diabetes (T2D) and osteoporosis should consider the scientific evidence, according to a review published online June 21 in the Journal of Clinical Endocrinology & Metabolism.

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Occupation Tied to Risk of Vitamin D Deficiency

THURSDAY, June 22, 2017 (HealthDay News) -- Shiftworkers, healthcare workers, and indoor workers are at high risk of developing vitamin D deficiency, according to a review published online June 22 in BMC Public Health.

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1991-2014 Saw Minimal Change in Health Spending Per State

THURSDAY, June 22, 2017 (HealthDay News) -- From 1991 to 2014 there was minimal change in health spending by state, according to a study published online June 14 in Health Affairs.

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sRAGE Linked to Risk of Incident Diabetic Nephropathy

THURSDAY, June 22, 2017 (HealthDay News) -- Serum levels of soluble receptor for advanced glycation end products (sRAGE) are associated with the risk of developing incident diabetic nephropathy (DN) in individuals with type 1 diabetes, according to a study published online June 19 in Diabetes Care.

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Medical-Home Recognition Higher in Demonstration Sites

THURSDAY, June 22, 2017 (HealthDay News) -- Demonstration sites, which are provided with care management fees and technical assistance to help them achieve the highest medical-home recognition, do have higher rates of medical-home recognition, according to a study published online June 21 in the New England Journal of Medicine.

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Diabetic Ketoacidosis Poses Fetal Risk During/After Event

WEDNESDAY, June 21, 2017 (HealthDay News) -- Diabetic ketoacidosis (DKA) during pregnancy poses risk for the fetus during and after the event, according to research published online June 12 in Diabetes Care.

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More Americans Using High-Doses of Vitamin D Supplementation

TUESDAY, June 20, 2017 (HealthDay News) -- Rising numbers of Americans may be getting too much vitamin D via supplementation, according to a research letter published in the June 20 issue of the Journal of the American Medical Association.

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Age a Factor in Patients Leaving Hospital Against Medical Advice

TUESDAY, June 20, 2017 (HealthDay News) -- Although patients aged 65 and older are four times less likely to leave the hospital against medical advice than adults under 65, race/ethnicity and poverty appear to increase this risk in elderly inpatients, according to a study published online June 19 in the Journal of the American Geriatrics Society.

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Risk of Cardiovascular Events Similar With, Without Diabetes

TUESDAY, June 20, 2017 (HealthDay News) -- For patients undergoing coronary angiography (CAG), those with and without diabetes without coronary artery disease (CAD) have the same risk of death, cardiac death, and myocardial infarction, according to a study published online June 8 in Diabetes Care.

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PCSK9 Increased in Females, Youth With Type 1 Diabetes

MONDAY, June 19, 2017 (HealthDay News) -- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is increased in young females and youth with type 1 diabetes (T1D), according to research published online June 6 in Diabetes Care.

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Health Insurers Recruiting Former Pharma Reps to Cut Costs

FRIDAY, June 16, 2017 (HealthDay News) -- Health insurers are recruiting former pharmaceutical company representatives to educate doctors and help save money on prescription medications, according to a report published June 8 in Kaiser Health News.

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Replacing Saturated Fats With Healthy Fats Lowers CVD Risk

FRIDAY, June 16, 2017 (HealthDay News) -- Replacing saturated fats with polyunsaturated fats and monounsaturated fats can reduce cardiovascular disease risk as much as statins, according to a new American Heart Association (AHA) advisory published online June 15 in Circulation.

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Text Messaging Intervention Can Up Glycemic Control in T2DM

FRIDAY, June 16, 2017 (HealthDay News) -- For low-income Hispanic patients with poorly controlled type 2 diabetes, a text messaging intervention can improve glycemic control, according to a study published online June 9 in Diabetes Care.

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AMA Endeavors to Increase Transparency of Rx Pricing

THURSDAY, June 15, 2017 (HealthDay News) -- The American Medical Association (AMA) is calling for more transparency in drug pricing amid rising costs that are putting some lifesaving medications out of reach for patients and communities.

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Nomogram Predicts Survival for Adults Undergoing CAC Scoring

THURSDAY, June 15, 2017 (HealthDay News) -- A simple-to-use nomogram can predict five-, 10-, and 15-year survival among adults undergoing coronary artery calcium scoring (CACS), according to a study published online June 14 in JACC: Cardiovascular Imaging.

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Concentrated Broccoli Sprout Extract May Help Fight T2DM

THURSDAY, June 15, 2017 (HealthDay News) -- Sulforaphane, found in cruciferous vegetables such as broccoli, may help obese type 2 diabetes patients better regulate dysglycemia, according to a study published in the June 14 issue of Science Translational Medicine.

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Good Results for Zone MPC-Based Artificial Pancreas

THURSDAY, June 15, 2017 (HealthDay News) -- A zone model predictive control (MPC)-based artificial pancreas (AP) system improves glycemic control in a home-use environment, according to a study published online June 5 in Diabetes Care.

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Glycation of Hemoglobin Differs by Race

WEDNESDAY, June 14, 2017 (HealthDay News) -- Both biological and socioeconomic factors appear to play a role in higher hemoglobin A1c (HbA1c) readings seen in black patients with diabetes, according to research published online June 13 in the Annals of Internal Medicine.

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Metformin Tied to Decreased BMI z Score in Prepubertal Children

WEDNESDAY, June 14, 2017 (HealthDay News) -- In prepubertal, but not pubertal, obese children, metformin is associated with decreased body mass index (BMI) z score and improved inflammatory and cardiovascular-related obesity parameters, according to a study published online June 12 in Pediatrics.

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Sleep Apnea Linked to Diabetic Retinopathy in Type 2 Diabetes

WEDNESDAY, June 14, 2017 (HealthDay News) -- For patients with type 2 diabetes, obstructive sleep apnea (OSA) is associated with sight-threatening diabetic retinopathy (STDR) and with progression to pre-/proliferative DR, according to a study published online June 8 in the American Journal of Respiratory and Critical Care Medicine.

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Food Cravings Down With Extended Calorie Restriction

TUESDAY, June 13, 2017 (HealthDay News) -- Extended calorie restriction is associated with a reduction in food cravings, according to a review and meta-analysis published online May 30 in Obesity Reviews.

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Medical Students Lacking Proficiency in BP Measurements

MONDAY, June 12, 2017 (HealthDay News) -- Medical students frequently do not achieve mastery of the skills necessary for accurate measurement of blood pressure (BP), according to a study published online April 28 in the Journal of Clinical Hypertension.

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Vitamin B6 Linked to Increased Risk of Hip Fracture

MONDAY, June 12, 2017 (HealthDay News) -- Vitamin B6, but not vitamin B12, is associated with increased risk of hip fracture during extended follow-up, according to a study published online June 2 in the Journal of Bone and Mineral Research.

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Review: Depression Screening As Inpatient Important, Feasible

MONDAY, June 12, 2017 (HealthDay News) -- Depression affects about one-third of hospital patients and could slow their recovery, according to research published recently in the Journal of Hospital Medicine.

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CDC: Kidney Disease Affects One in Seven Americans

MONDAY, June 12, 2017 (HealthDay News) -- Thirty million American adults (one in seven) have chronic kidney disease -- but many don't know it, according to an analysis of data from the U.S. Centers for Disease Control and Prevention.

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New Bill With Tort Reforms Will Protect Iowa Physicians

FRIDAY, June 9, 2017 (HealthDay News) -- A new bill with tort reforms to protect Iowa physicians will take effect July 1, according to a report published by the American Medical Association (AMA).

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Sitagliptin Stimulates Distal Tubular Natriuresis in T2DM

FRIDAY, June 9, 2017 (HealthDay News) -- For patients with type 2 diabetes, the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin stimulates distal tubular natriuresis, according to a study published online May 26 in Diabetes Care.

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U.S. Leads in Income-Based Health Care Inequalities

THURSDAY, June 8, 2017 (HealthDay News) -- The United States has larger income-related differences in perceptions of health and health care than other middle- and high-income countries, according to a report published in the June issue of Health Affairs.

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Certain Cancer Diagnoses Up in High-Income Counties in U.S.

THURSDAY, June 8, 2017 (HealthDay News) -- Americans living in high-income areas are more likely to be diagnosed with some types of cancer than people living in low-income areas, according to a perspective piece published in the June 8 issue of the New England Journal of Medicine.

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SGLT2 Inhibitors Linked to Increased Risk of Ketoacidosis

THURSDAY, June 8, 2017 (HealthDay News) -- Sodium-glucose cotransporter 2 (SGLT2) inhibitors appear to increase the risk of diabetic ketoacidosis in patients with type 2 diabetes, according to a research letter published in the June 8 issue of the New England Journal of Medicine.

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Health System Sees Success With E-Visits Via Patient Portal

WEDNESDAY, June 7, 2017 (HealthDay News) -- Patient portals can successfully offer access to physicians without office visits, according to a report published online May 30 by the American Medical Association.

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Severe Hypoglycemia Rates Have Equilibrated for DCCT Groups

WEDNESDAY, June 7, 2017 (HealthDay News) -- Rates of severe hypoglycemia have equilibrated between the two Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) treatment groups in association with duration of diabetes and HbA1c level, according to a study published online May 26 in Diabetes Care.

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Lifespan Up With Adoption of Four Healthy Lifestyle Behaviors

WEDNESDAY, June 7, 2017 (HealthDay News) -- Adoption of four healthy lifestyle behaviors is associated with increased lifespan for men and women, according to a study published online May 31 in the Journal of Internal Medicine.

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CDC: High-Deductible Health Plan Use Rising Among Employers

WEDNESDAY, June 7, 2017 (HealthDay News) -- High-deductible health plans are becoming more common among U.S. adults with employer-sponsored health insurance coverage, according to a report issued June 6 by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Many Bariatric Surgery Patients Using Opioids Seven Years Later

WEDNESDAY, June 7, 2017 (HealthDay News) -- About 20 percent of U.S. bariatric surgery patients are still using prescription opioids seven years later, according to a study published recently in Surgery for Obesity and Related Diseases.

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Combo of Several Meds at Smaller Doses May Boost HTN Care

TUESDAY, June 6, 2017 (HealthDay News) -- Combining low doses of several different antihypertensive medications may be better than using a standard dose of just one drug, according to a review published online June 5 in Hypertension.

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Lower HbA1c Linked to Better Diabetes-Specific HRQoL in Youth

TUESDAY, June 6, 2017 (HealthDay News) -- For children, teens, and young adults with type 1 diabetes mellitus (T1DM), hemoglobin A1c (HbA1c) is associated with better diabetes-specific health-related quality of life (D-HRQoL), according to a study published online May 25 in Diabetes Care.

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Non-Shivering Thermogenesis Can Activate Metabolic Pathways

MONDAY, June 5, 2017 (HealthDay News) -- Non-shivering thermogenesis can transform storage adipose tissues into metabolically active tissue, according to research published online May 25 in Obesity Reviews.

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Hypothalamic Lin28a Shows Role in Glucose Homeostasis

MONDAY, June 5, 2017 (HealthDay News) -- An experimental study supports a TANK-binding kinase 1 (TBK-1)-dependent role for Lin28a in the hypothalamic ventromedial nucleus in glucose homeostasis. The study was published online May 26 in Diabetes.

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Cool Water Works As Well As Hot for Ridding Hands of Germs

FRIDAY, June 2, 2017 (HealthDay News) -- For effective hand hygiene, water temperature matters less than time, according to a study published in the June issue of the Journal of Food Protection.

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Reducing SBP Targets Below Current Guidelines Cuts Risk

FRIDAY, June 2, 2017 (HealthDay News) -- For adults with hypertension treated with antihypertensive medication, reducing systolic blood pressure (SBP) levels to 120 to 124 mm Hg is associated with reduced risk of cardiovascular disease and all-cause mortality, according to a review published online May 31 in JAMA Cardiology.

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Comorbid Celiac Disease Common Among Youth With T1DM

FRIDAY, June 2, 2017 (HealthDay News) -- Children with type 1 diabetes often have comorbid celiac disease (CD), according to a study published online May 25 in Diabetes Care.

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Excess Weight Increases Costs Across Health Care Settings

THURSDAY, June 1, 2017 (HealthDay News) -- Excess weight is associated with increased costs across health care settings, with the highest percentage increases seen in costs for medications, according to research published online May 22 in Obesity Reviews.

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Medication Adherence Up With Refill Synchronization Model

THURSDAY, June 1, 2017 (HealthDay News) -- An appointment-based model (ABM) which synchronizes medication refills to improve medication adherence is associated with improvement in medication-taking behavior, according to a review published online May 8 in the Journal of Clinical Pharmacy and Therapeutics.

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