June 2016 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for June 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Butter May Not Be As Unhealthy As Previously Thought

THURSDAY, June 30, 2016 (HealthDay News) -- Butter may not be the unhealthy food many Americans believe it to be; however, that doesn't mean that butter provides any real health benefit, according to research published online June 29 in PLOS ONE.

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Testosterone Gel Improves Sexual Function in Older Men

THURSDAY, June 30, 2016 (HealthDay News) -- Older men treated with testosterone gel experience a moderate but significant improvement in their sex drive, sexual activity, and erectile function compared to men given a placebo gel, according to a study published online June 29 in the Journal of Clinical Endocrinology and Metabolism.

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Metabolomics Signature Can Predict GDM to T2DM Transition

THURSDAY, June 30, 2016 (HealthDay News) -- A metabolomics signature can predict the transition from gestational diabetes mellitus (GDM) to type 2 diabetes (T2D), according to a study published online June 23 in Diabetes.

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Too Little, Too Much Sleep Can Impair Insulin Sensitivity in Men

WEDNESDAY, June 29, 2016 (HealthDay News) -- Too much or too little sleep may raise the risk of diabetes in men, but not women, according to a study published online June 29 in the Journal of Clinical Endocrinology & Metabolism.

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Electronic Record Demands Are Overwhelming Many Physicians

WEDNESDAY, June 29, 2016 (HealthDay News) -- Physicians using electronic practice tools report higher rates of burnout and increased frustration with the amount of computerized paperwork, according to research published online June 27 in the Mayo Clinic Proceedings.

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Gastric Bypass Helps Achieve Diabetes Treatment Goals

WEDNESDAY, June 29, 2016 (HealthDay News) -- The addition of Roux-en-Y gastric bypass to lifestyle-medical management is associated with improved achievement of treatment goals in type 2 diabetes, according to a study published online June 16 in Diabetes Care.

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Gastric Bypass Cuts Hormonal Responses to Hypoglycemia

TUESDAY, June 28, 2016 (HealthDay News) -- Gastric bypass (GBP) surgery is associated with reduced symptoms and neurohormonal responses to hypoglycemia, according to a study published online June 16 in Diabetes.

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Patients Face High Hospital Bills Despite Having Insurance

MONDAY, June 27, 2016 (HealthDay News) -- Costs of hospitalization for privately insured adults rose more than 37 percent over five years, with patients paying more than $1,000 on average by 2013, according to research published online June 27 in JAMA Internal Medicine.

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Liraglutide Tops Lixisenatide As Add-On to Metformin in T2DM

MONDAY, June 27, 2016 (HealthDay News) -- For patients with type 2 diabetes taking metformin, add-on liraglutide is more effective than lixisenatide for improving glycemic control, according to a study published online June 16 in Diabetes Care.

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Daily Calcium Intake of 1,000 or 2,000 mg Best for Rickets

MONDAY, June 27, 2016 (HealthDay News) -- For children with rickets, radiographic healing is more rapid with 1,000 mg and 2,000 mg daily calcium intake compared with 500 mg, according to a study published online June 17 in the Journal of Bone and Mineral Research.

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Diabetes Increases Mortality Risk After Acute Myocardial Infarction

FRIDAY, June 24, 2016 (HealthDay News) -- Patients with diabetes are much more likely to die after an acute myocardial infarction (AMI) than patients without diabetes, according to a study published online June 15 in the Journal of Epidemiology and Community Health.

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2017 Will Bring Premium Rate Increases Under ACA

FRIDAY, June 24, 2016 (HealthDay News) -- Health insurance premiums under the Affordable Care Act will rise in 2017, analysts and insurance brokers say.

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Diabetes Plus Kidney Disease Raises CVD Risk in Blacks

FRIDAY, June 24, 2016 (HealthDay News) -- For black Americans with diabetes, chronic kidney disease (CKD) appears to increase the risk of cardiovascular mortality, according to a study published online June 23 in the Clinical Journal of the American Society of Nephrology.

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Novel Lipid Mediators May Play Role in Omega-3 PUFA Effects

FRIDAY, June 24, 2016 (HealthDay News) -- Novel lipid mediators may be involved in the beneficial effects associated with omega-3 polyunsaturated fatty acids (PUFAs) in obesity, according to a study published online June 16 in Diabetes.

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CDC: Alternative Medicine a Booming Business in U.S.

WEDNESDAY, June 22, 2016 (HealthDay News) -- Americans spent more than $30 billion out of pocket in 2012 on chiropractors and other complementary health practitioners, as well as supplements and other forms of alternative medicine, according to research published online June 22 in the U.S. Centers for Disease Control and Prevention's National Health Statistics Reports.

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Daily Steps in Children With T1DM Tied to Early Atherosclerosis

WEDNESDAY, June 22, 2016 (HealthDay News) -- For children with type 1 diabetes, the number of daily steps is associated with early signs of atherosclerosis and adverse cardiovascular risk, according to a study published online June 15 in Diabetes Care.

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Male PCPs Less Likely to Assess CVD Risk in Female Patients

WEDNESDAY, June 22, 2016 (HealthDay News) -- Many male primary care physicians regard cardiovascular disease as a man's issue and don't assess risk in female patients, according to research published online June 21 in the European Journal of Preventive Cardiology.

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Nine-Protein Risk Score May Help Predict CV Events in Stable CHD

WEDNESDAY, June 22, 2016 (HealthDay News) -- A nine-protein risk score may help predict cardiovascular events among patients with stable coronary heart disease (CHD), according to a study published in the June 21 issue of the Journal of the American Medical Association.

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50 Percent Insulin Lispro/Insulin Lispro Protamine Efficacious

WEDNESDAY, June 22, 2016 (HealthDay News) -- For East Asian patients with type 2 diabetes, 50 percent insulin lispro/50 percent insulin lispro protamine (LM50) is more efficacious as starter insulin than 25 percent insulin lispro/75 percent insulin lispro protamine (LM25), according to a study published online June 8 in the Journal of Diabetes Investigation.

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25(OH)D Levels Linked to Survival in Pancreatic Cancer

WEDNESDAY, June 22, 2016 (HealthDay News) -- Prediagnostic 25-hydroxyvitamin D (25[OH]D) levels are associated with survival in pancreatic cancer, according to a study published online June 20 in the Journal of Clinical Oncology.

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APCs, Doctors Order Low-Value Services With Similar Frequency

WEDNESDAY, June 22, 2016 (HealthDay News) -- Advanced practice clinicians (APCs) and physicians order low-value health services with similar frequency, according to a study published online June 20 in the Annals of Internal Medicine.

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Tips Provided for Leveraging Social Media

TUESDAY, June 21, 2016 (HealthDay News) -- During a presentation at the 2016 American Medical Association Annual Meeting, Kevin Pho, M.D., founder and editor of the popular physician blog KevinMD, shared insights into making a difference in health care through use of social media.

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Moderately Low LDL May Be Enough to Ward Off CVD Risk

TUESDAY, June 21, 2016 (HealthDay News) -- Very low target low-density lipoprotein (LDL) cholesterol levels may not benefit all patients with preexisting heart disease, according to a study published online June 20 in JAMA Internal Medicine.

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Persistent High Spending Common in Year Before Death

TUESDAY, June 21, 2016 (HealthDay News) -- Almost half of older Medicare beneficiaries have high persistent spending throughout the full year before death, according to a study published in the June issue of Health Affairs.

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Long-Term Pioglitazone Safe, Effective for NASH, T2DM

TUESDAY, June 21, 2016 (HealthDay News) -- For patients with prediabetes or type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH), long-term pioglitazone is safe and effective, according to a study published online June 21 in the Annals of Internal Medicine.

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Risk of T1DM Up in Children With Autoantibody Reversion

TUESDAY, June 21, 2016 (HealthDay News) -- The risk of type 1 diabetes remains elevated for children who have developed multiple β-cell autoantibodies, even after reversion of individual autoantibodies, according to a study published online June 16 in Diabetes Care.

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Striatal D2 Receptors, Age Linked to Sucrose Preference

TUESDAY, June 21, 2016 (HealthDay News) -- For subjects without obesity, striatal D2 receptor (D2R) binding potential and age are associated with sucrose preference, according to a study published online June 15 in Diabetes.

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One Free Meal From Industry Ups Brand-Name Rx Among Doctors

MONDAY, June 20, 2016 (HealthDay News) -- Physicians who receive even one free meal, valued at less than $20 on average, are more likely to prescribe a promoted brand-name drug than a cheaper generic alternative, compared with doctors who did not accept a meal, according to a study published online June 20 in JAMA Internal Medicine.

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Reset Room Can Help Address Physician Burnout

MONDAY, June 20, 2016 (HealthDay News) -- The creation of a reset room is one of several solutions that can help physicians and medical providers address burnout, according to a report published by the American Medical Association.

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Bariatric Surgery Improves Adipose Tissue Function

MONDAY, June 20, 2016 (HealthDay News) -- Bariatric surgery is associated with improvements in adipose tissue function, some of which are independent of weight loss, according to research published online June 8 in Obesity Reviews.

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Dulaglutide, Glargine Plus Lispro Improve Glycemic Control

MONDAY, June 20, 2016 (HealthDay News) -- Dulaglutide and glargine in combination with prandial lispro are associated with a similar percentage of time spent in the normoglycemic range, according to a study published online June 9 in Diabetes, Obesity and Metabolism.

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Vildagliptin, Sitagliptin Have Similar Effects on Incretin

MONDAY, June 20, 2016 (HealthDay News) -- The dipeptidyl peptidase-4 (DPP-4) inhibitors vildagliptin and sitagliptin have similar effects on incretin hormone secretion, according to a study published online June 14 in Diabetes, Obesity and Metabolism.

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Intervention Combination Can Cut Pediatric Hypoglycemic Events

FRIDAY, June 17, 2016 (HealthDay News) -- A multi-interventional approach can reduce preventable hypoglycemic events in hospitalized pediatric patients receiving insulin, according to a study published online June 17 in Pediatrics.

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Strategy Needed to Address Impending Physician Shortage

FRIDAY, June 17, 2016 (HealthDay News) -- Steps should be taken to combat the impending physician shortage of between 61,700 and 94,700 doctors that the United States is expected to face over the next decade, according to an article published in Medical Economics.

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Gluten-Free Diet Beneficial in T1D With Concurrent Celiac Disease

FRIDAY, June 17, 2016 (HealthDay News) -- For children with type 1 diabetes (T1D), the negative influence of celiac disease (CD) on high-density lipoprotein cholesterol (HDL-C) can be improved by adherence to a gluten-free diet (GFD), according to a study published online June 6 in Diabetes Care.

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Varying Safety of Add-On Second-Line T2DM Treatments

FRIDAY, June 17, 2016 (HealthDay News) -- For patients with type 2 diabetes who are taking metformin, the risk of cardiovascular events and mortality varies with the addition of different second-line therapies, according to a study published online June 10 in Diabetes, Obesity and Metabolism.

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Soles of the Feet Should Also Be Checked for Skin Cancer

THURSDAY, June 16, 2016 (HealthDay News) -- Stress and damage caused by walking or running could be a risk factor for melanoma on the soles of the feet, according to a research letter published in the June 16 issue of the New England Journal of Medicine.

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Pharmacist Involvement Can Improve Cardiovascular Care

THURSDAY, June 16, 2016 (HealthDay News) -- Patients with poorly controlled cardiovascular disease (CVD) risk factors could improve their prognosis by having pharmacists help manage their care, according to a study published in the June 21 issue of the Journal of the American College of Cardiology.

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Potential Impact of Single-Payer Health Care Discussed

THURSDAY, June 16, 2016 (HealthDay News) -- Democratic presidential candidate Bernie Sanders is promoting his version of single-payer health care, although the actual impact of such a system is unclear, according to a report published in Medical Economics.

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Most Websites, Apps Not Accurate for Predicting Fertile Window

THURSDAY, June 16, 2016 (HealthDay News) -- Most fertility websites and applications (apps) are not accurate for predicting the fertile window, according to a study published in the July issue of Obstetrics & Gynecology.

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Genetic Data Help ID Risk of Future Impaired Fasting Glucose

THURSDAY, June 16, 2016 (HealthDay News) -- The addition of genetic risk variant data to conventional childhood risk factors improves risk assessment of impaired fasting glucose (IFG) and type 2 diabetes in adulthood, according to a study published online June 13 in Diabetes Care.

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Prices for Care Rise Significantly As Multi-Hospital Systems Emerge

THURSDAY, June 16, 2016 (HealthDay News) -- Hospital prices in California increased substantially from 2004 to 2013, with a larger increase in hospitals that are members of multi-hospital systems, according to a study published online June 9 in Inquiry.

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HIV Infection Negatively Affects Bone Acquisition

WEDNESDAY, June 15, 2016 (HealthDay News) -- HIV infection with T cell activation is associated with lower bone mineral density (BMD) and stiffness, according to a study published online June 10 in the Journal of Bone and Mineral Research.

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Four-Step Strategy Suggested for Boosting Practice Quality of Care

WEDNESDAY, June 15, 2016 (HealthDay News) -- Four steps can help doctors improve patient care and office efficiency, according to a report published by the American Medical Association (AMA).

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Even Short-Term T2DM Remission Reduces Risk of Microvascular Dz

TUESDAY, June 14, 2016 (HealthDay News) -- For patients with type 2 diabetes, remission after bariatric surgery is associated with a reduced risk of microvascular disease, even after subsequent relapse, according to a study published online June 6 in Diabetes Care.

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American Seniors With Diabetes Living Longer Without Disability

MONDAY, June 13, 2016 (HealthDay News) -- American seniors with diabetes are starting to live longer without disabilities, according to a study published online June 10 in The Lancet Diabetes & Endocrinology.

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Review Links H. pylori Infection With Metabolic Syndrome

MONDAY, June 13, 2016 (HealthDay News) -- Helicobacter pylori infection is associated with metabolic syndrome, according to a review and meta-analysis published online June 7 in the Journal of Digestive Diseases.

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Elevated 3 Alpha-Diol G Levels for Many Women With Acne

FRIDAY, June 10, 2016 (HealthDay News) -- About half of adult women with acne, with normal androgenic status, have elevated levels of 3 alpha-diol G, according to a study published online June 6 in the Journal of Cosmetic Dermatology.

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Risk of S. aureus Bacteremia Up in Patients on Glucocorticoids

FRIDAY, June 10, 2016 (HealthDay News) -- Patients taking systemic glucocorticoids are at higher risk for community-acquired Staphylococcus aureus bacteremia (CA-SAB), according to research published online June 8 in Mayo Clinic Proceedings.

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Oral Contraceptive Use Ups Surgery Risk in Crohn's

FRIDAY, June 10, 2016 (HealthDay News) -- For females with Crohn's disease (CD), long-term use of oral contraceptives (OCs) is associated with increased risk of surgery, according to a study published in the June issue of Gastroenterology.

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CYP2C8, SLCO1B1 Variants Impact Response to Rosiglitazone

FRIDAY, June 10, 2016 (HealthDay News) -- Genetic variants in CYP2C8 and SLCO1B1 impact the therapeutic response to rosiglitazone in patients with type 2 diabetes, according to a study published online June 6 in Diabetes Care.

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Aflibercept, Ranibizumab Not Cost-Effective Vs. Bevacizumab

FRIDAY, June 10, 2016 (HealthDay News) -- Compared with bevacizumab, aflibercept and ranibizumab are not cost-effective for diabetic macular edema (DME), according to research published online June 9 in JAMA Ophthalmology.

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Postural Instability Predicts Off-Loading Nonadherence in T2DM

THURSDAY, June 9, 2016 (HealthDay News) -- For patients with diabetic foot ulcers (DFUs), off-loading adherence is associated with healing, but postural instability is a powerful predictor of nonadherence, according to a study published online June 6 in Diabetes.

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Chemo Ups Metabolic Syndrome Risk in Early-Stage Breast Cancer

THURSDAY, June 9, 2016 (HealthDay News) -- For patients with early-stage breast cancer with no preexisting metabolic syndrome (MetS), chemotherapy is associated with increased risk of MetS, according to a study published online May 24 in Cancer.

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No Significant Weight Change With Adjuvant Sulfonylureas

WEDNESDAY, June 8, 2016 (HealthDay News) -- Sulfonylureas used as add-on therapy to metformin can maintain glycemic control in type 2 diabetes, without changing body weight, according to a study published online June 6 in Diabetes, Obesity and Metabolism.

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Diet Inclusive of Healthy Fats Does Not Lead to Weight Gain

TUESDAY, June 7, 2016 (HealthDay News) -- An eating plan that includes healthy fats such as olive oil and nuts isn't likely to cause weight gain, according to a study published online June 6 in The Lancet Diabetes & Endocrinology.

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Obesity Rates on the Rise Among Women, but Not Men

TUESDAY, June 7, 2016 (HealthDay News) -- More American women than ever are obese, while the number of obese men has held steady, according to a study published in the June 7 issue of the Journal of the American Medical Association. Another study in the same issue found that excess weight is also still a concern for adolescents.

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Opinions Vary on Management of Subclinical Hypothyroidism

TUESDAY, June 7, 2016 (HealthDay News) -- Physicians' opinions on management of subclinical hypothyroidism vary, according to a Beyond the Guidelines article published online June 7 in the Annals of Internal Medicine.

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Severe Hypoglycemia Risk Nearly Doubles With Intensive T2DM Tx

MONDAY, June 6, 2016 (HealthDay News) -- Intensive diabetes mellitus treatment nearly doubles the risk of severe hypoglycemia requiring medical attention in clinically complex patients, according to a study published online June 6 in JAMA Internal Medicine.

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U-Shaped Pattern for Dietary Calcium Intake, Fracture Risk

MONDAY, June 6, 2016 (HealthDay News) -- Dietary calcium intake seems to have a U-shaped correlation with fracture risk in men and possibly in women, according to a study published online May 21 in the Journal of Bone and Mineral Research.

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Few Engage in Five Behaviors for Preventing Chronic Disease

MONDAY, June 6, 2016 (HealthDay News) -- Few U.S. adults engage in all five health-related behaviors recommended for chronic disease prevention, according to a study published online May 26 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Post-CABG Infection Risk Up Significantly for Severely Obese

FRIDAY, June 3, 2016 (HealthDay News) -- Severely obese patients may have a higher risk of certain complications after coronary artery bypass grafting (CABG) surgery than normal-weight patients, according to a study published online June 1 in the Journal of the American Heart Association.

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Twin Gestation Ups Risk of Gestational Diabetes Mellitus

FRIDAY, June 3, 2016 (HealthDay News) -- Twin gestation is associated with increased risk of gestational diabetes mellitus (GDM), according to an article published online May 23 in Diabetes Care.

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Depressive Symptoms Linked to Reduced Fecundability

FRIDAY, June 3, 2016 (HealthDay News) -- Depressive symptoms are associated with reduced fecundability, according to a study published online April 28 in the American Journal of Obstetrics and Gynecology.

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Hypocaloric Diet, Exercise Both Reduce Visceral Adiposity

FRIDAY, June 3, 2016 (HealthDay News) -- Both hypocaloric diet and exercise reduce visceral adiposity (VAT), with exercise tending to have a larger effect on reducing VAT, according to a review published online May 23 in Obesity Reviews.

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AMA Module Promotes Training of Medical Assistants

THURSDAY, June 2, 2016 (HealthDay News) -- A new training module can improve training for medical assistants (MAs), according to a report from the American Medical Association (AMA).

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Genes May Lower Risk of Obesity in Men of West African Descent

THURSDAY, June 2, 2016 (HealthDay News) -- A new study has identified genetic factors in black men with a strong West African ancestry that are associated with a lower risk of central obesity. But this apparent benefit doesn't extend to black women, regardless of their lineage. The study findings were published online June 1 in Frontiers in Genetics.

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Patients Like to See Physicians Wearing White Coats

THURSDAY, June 2, 2016 (HealthDay News) -- Most patients prefer that physicians wear white coats, according to research published online June 1 in JAMA Dermatology.

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Low Glycemic Index Diet Linked to Drop in Uric Acid Levels

THURSDAY, June 2, 2016 (HealthDay News) -- Reducing the dietary glycemic index is associated with a reduction in uric acid levels among overweight and obese adults, according to a study published in the May issue of Arthritis & Rheumatology.

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Premenstrual Estrogen Levels Drop More Rapidly in Migraineurs

THURSDAY, June 2, 2016 (HealthDay News) -- In women who get migraines, levels of estrogen drop more rapidly in the days before menstruation, compared to that seen in women without migraines, according to a study published online June 1 in Neurology.

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FDA Urges Food Manufacturers to Reduce Sodium in Their Products

WEDNESDAY, June 1, 2016 (HealthDay News) -- The U.S. Food and Drug Administration wants the food industry to voluntarily reduce the amount of sodium in processed and commercially prepared food.

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Parathyroidectomy Ups QOL in Primary Hyperparathyroidism

WEDNESDAY, June 1, 2016 (HealthDay News) -- Patients undergoing parathyroidectomy for primary hyperparathyroidism (PHPT) have lower quality-of-life (QOL) than controls undergoing thyroid surgery, but QOL improves after surgery, according to a study published in the June issue of Head & Neck.

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Gut Microbiome Tied to Metabolic Hormones in Early Pregnancy

WEDNESDAY, June 1, 2016 (HealthDay News) -- In overweight and obese women, gut microbiome composition is associated with the metabolic hormonal environment at 16 weeks of gestation, according to a study published in the May issue of Diabetes.

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