July 2016 Briefing - Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for July 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

About One in Five Have Recurrent Diabetic Ketoacidosis

FRIDAY, July 29, 2016 (HealthDay News) -- Recurrent diabetic ketoacidosis (DKA) is common, occurring in more than one in five patients, according to a study published online July 15 in Diabetes Care.

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Usual Apixaban Dosing OK With One Dose-Reduction Criterion

FRIDAY, July 29, 2016 (HealthDay News) -- For patients in the Apixaban for Reduction of Stroke and Other Thromboembolic Complications in Atrial Fibrillation (ARISTOTLE) trial, the 5 mg twice daily dose of apixaban is beneficial and appropriate for those with one dose-reduction criterion, according to a study published online July 27 in JAMA Cardiology.

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Online Communication Tied to Positive Appraisal of Tx Decisions

FRIDAY, July 29, 2016 (HealthDay News) -- For women with newly diagnosed breast cancer, frequent online communication users more positively appraise their decision making, according to a research letter published online July 28 in JAMA Oncology.

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FDA Approves Adlyxin for Type 2 Diabetes Mellitus

THURSDAY, July 28, 2016 (HealthDay News) -- Adlyxin (lixisenatide), a glucagon-like peptide-1 receptor agonist, has been approved by the U.S. Food and Drug Administration to treat type 2 diabetes in adults, the agency said Thursday in a news release.

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Add-On Local Peripheral Tx Beneficial in Metastatic Melanoma

THURSDAY, July 28, 2016 (HealthDay News) -- For patients with metastatic melanoma, the addition of local peripheral treatments (LPT) such as radiotherapy or electrochemotherapy is beneficial, according to a study published online July 27 in Cancer Immunology Research.

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Perceived Stigmatization Common for Patients With Psoriasis

WEDNESDAY, July 27, 2016 (HealthDay News) -- Sociodemographic, disease-related, and personality variables can predict perceived stigmatization in psoriasis, which occurs in the majority of patients, according to a study published online July 20 in the British Journal of Dermatology.

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FDA Strengthens Safety Warnings for Fluoroquinolones

WEDNESDAY, July 27, 2016 (HealthDay News) -- The U.S. Food and Drug Administration announced Tuesday that it's strengthening label warnings on fluoroquinolones because the drugs can lead to disabling side effects, including long-term nerve damage and ruptured tendons.

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Flu Vaccine Protective Against Hospitalization, Death in T2DM

WEDNESDAY, July 27, 2016 (HealthDay News) -- The seasonal influenza vaccine may significantly reduce mortality for patients with type 2 diabetes, as well as hospitalizations for stroke and cardiovascular and pulmonary issues, according to a study published online July 25 in CMAJ, the journal of the Canadian Medical Association.

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Variation in Risk of Adverse Outcomes With Metamizole

WEDNESDAY, July 27, 2016 (HealthDay News) -- The magnitude of the risk of adverse outcomes associated with metamizole use varies in different studies, according to a review published online July 15 in the Journal of Clinical Pharmacy and Therapeutics.

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Blunted, More Variable Insulin Action in Lipohypertrophy

WEDNESDAY, July 27, 2016 (HealthDay News) -- Insulin lispro injection into lipohypertrophic tissue (LHT) results in considerable impairment and increased variability in insulin absorption and action, according to a study published in online July 13 in Diabetes Care.

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Ob-Gyns Should Counsel Patients on Immediate Postpartum LARC

TUESDAY, July 26, 2016 (HealthDay News) -- Obstetrician-gynecologists should counsel pregnant women about use of long-acting reversible contraception (LARC), such as implants and intrauterine devices (IUDs), immediately after they give birth, according to an American College of Obstetricians and Gynecologists (ACOG) Committee Opinion published in the August issue of Obstetrics & Gynecology.

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Primary Stroke Centers Have Slight Survival Edge

TUESDAY, July 26, 2016 (HealthDay News) -- The odds of surviving a stroke are slightly better for patients treated at hospitals with primary stroke centers (PSCs), but only if stroke patients get to the center in less than 90 minutes, according to research published online July 25 in JAMA Internal Medicine.

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American Red Cross Says Blood Donations Needed Urgently

TUESDAY, July 26, 2016 (HealthDay News) -- The American Red Cross says it has an urgent need for blood donations, with less than a five-day supply of blood on hand to help those who need it.

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Teen Athletes at Low Risk for Opioid Addiction

TUESDAY, July 26, 2016 (HealthDay News) -- Teenage athletes are less likely to abuse opioids than adolescents who don't play sports or exercise, according to research published online July 25 in Pediatrics.

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Marijuana Poisonings in Toddlers on the Rise in Colorado

TUESDAY, July 26, 2016 (HealthDay News) -- In 2014, Colorado and Washington became the first two states to legalize recreational marijuana. Shortly after, a sharp increase occurred in the number of Colorado children younger than 10 who became ill after being exposed to marijuana, according to a study published online July 25 in JAMA Pediatrics.

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Guidelines Developed for Pain Management in Cancer Survivors

TUESDAY, July 26, 2016 (HealthDay News) -- Guidelines have been developed for chronic pain management in adult cancer survivors. The American Society of Clinical Oncology Clinical Practice Guideline was published online July 25 in the Journal of Clinical Oncology.

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Recent Increases in Rate of Hep C Detection in Young Women

TUESDAY, July 26, 2016 (HealthDay News) -- From 2011 to 2014 there were increases in the rate of hepatitis C virus (HCV) detection among women of childbearing age, according to research published in the July 25 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Coenzyme Q10 Doesn't Prevent Periprocedural Myocardial Injury

MONDAY, July 25, 2016 (HealthDay News) -- Pre-treatment with coenzyme Q10 (CoQ10) before elective percutaneous coronary intervention (PCI) does not reduce periprocedural myocardial injury (PMI), but does significantly decrease high-sensitivity C-reactive protein (hs-CRP) levels, according to a study published online July 6 in Cardiovascular Therapeutics.

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Total Drug Expenditures Projected to Increase in 2016

MONDAY, July 25, 2016 (HealthDay News) -- Total drug expenditures are expected to increase by 11 to 13 percent in 2016, according to a study published online in the American Journal of Health-System Pharmacy.

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Antimicrobial Rx Up With Hospitalization for Acute Mania

MONDAY, July 25, 2016 (HealthDay News) -- Individuals hospitalized with acute mania have an increased rate of bacterial infections, as evidenced by the recent prescription of antimicrobial agents, according to a study published online July 17 in Bipolar Disorders.

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'Walking Meetings' Feasible Strategy for Employee Wellness

MONDAY, July 25, 2016 (HealthDay News) -- Converting a single weekly meeting to a walking meeting can help raise work-related physical activity levels of white-collar workers, according to a report published online June 23 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Meds Up Hospitalization for Dehydration, Heat-Linked Illness

MONDAY, July 25, 2016 (HealthDay News) -- Among veterans, initiation of many commonly-used medications is associated with increased risk of hospitalization for dehydration or heat-related illness, according to research published online July 4 in the Journal of Clinical Pharmacy and Therapeutics.

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Program Can Help Patient-Centered Practice Transition

FRIDAY, July 22, 2016 (HealthDay News) -- A new study describes a scalable solution for transforming health care delivery in primary care into the patient-centered medical home model. The report was published online July 15 in the Journal of Cognitive Engineering and Decision Making.

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Severe Hypoglycemia Linked to Mortality, CVD Events in T1DM

FRIDAY, July 22, 2016 (HealthDay News) -- For patients with type 1 diabetes mellitus (T1DM), severe hypoglycemia is associated with increased risk of all-cause mortality and cardiovascular disease (CVD), according to research published online July 6 in Diabetes Care.

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Widely Protective Vaccine Against Chlamydia Appears Promising

FRIDAY, July 22, 2016 (HealthDay News) -- A vaccine to help protect against chlamydia is proving to be effective, according to an experimental study published in the July 25 issue of Vaccine.

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Intake of Marine ω-3 PUFAs Tied to Colorectal Cancer Survival

FRIDAY, July 22, 2016 (HealthDay News) -- Colorectal cancer (CRC) patients who consume higher amounts of omega-3 polyunsaturated fatty acids (PUFAs), mainly from oily fish, may have better odds of survival, according to a study published online July 19 in Gut.

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Persistent Use Higher With New Generation Beta-Blockers

FRIDAY, July 22, 2016 (HealthDay News) -- Persistent use of antihypertensive treatments is greater with the new generation of beta-blockers, compared to atenolol, according to a study published in the August issue of Cardiovascular Therapeutics.

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Overall Mortality Similar in DCCT/EDIC, General Population

FRIDAY, July 22, 2016 (HealthDay News) -- Overall mortality is similar in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study cohort and the general population, according to a study published online July 13 in Diabetes Care.

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Antipsychotic Polypharmacy Has Prevalence of 12 Percent

FRIDAY, July 22, 2016 (HealthDay News) -- Among adult patients discharged from state psychiatric inpatient hospitals, the prevalence of antipsychotic polypharmacy is 12 percent, according to a study published in the July issue of the Journal of Psychiatric Practice.

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Rapid HIV Transmission Seen in Injection Drug Users in Rural U.S.

THURSDAY, July 21, 2016 (HealthDay News) -- The U.S. prescription drug abuse epidemic has increased the risk of HIV outbreaks in rural and suburban communities, where up to now the virus has posed little threat, according to a report published in the July 21 issue of the New England Journal of Medicine.

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Health Expenditures Rising for Middle Class, Wealthy

THURSDAY, July 21, 2016 (HealthDay News) -- While overall U.S. medical spending growth slowed between 2004 and 2013, expenditures rose for middle- and high-income Americans, according to research published in the July issue of Health Affairs.

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Buprenorphine-Naloxone Use in Medicare Patients Low

THURSDAY, July 21, 2016 (HealthDay News) -- Doctors aren't using one of the most effective weapons at their disposal in battling opioid addiction -- buprenorphine-naloxone (Suboxone), according to a research letter published online July 20 in JAMA Psychiatry.

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Drug Shows Promise for Genetic Proopiomelanocortin Deficiency

THURSDAY, July 21, 2016 (HealthDay News) -- An experimental drug spurred substantial weight loss in patients with proopiomelanocortin (POMC) deficiency, according to a study published in the July 21 issue of the New England Journal of Medicine.

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Seropositivity of Meningitis B Vaccine Lower Than Expected

THURSDAY, July 21, 2016 (HealthDay News) -- About one-third of Princeton University students given a vaccine to combat a meningitis B outbreak on campus in 2013 didn't show signs of protection against the infection eight weeks later, according to a study published in the July 21 issue of the New England Journal of Medicine.

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Estradiol Doesn't Boost Cognitive Function After Menopause

THURSDAY, July 21, 2016 (HealthDay News) -- Improvement in cognitive ability is not associated with estrogen therapy among women who use it after menopause, no matter when they start taking it, according to a study published online July 15 in Neurology.

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Buprenorphine May Be Helpful in Peripheral Neuropathic Pain

THURSDAY, July 21, 2016 (HealthDay News) -- For patients with moderate to severe diabetic peripheral neuropathic pain (DPNP), transdermal buprenorphine is effective for reducing pain, but is associated with adverse events, according to a study published online June 16 in Diabetes Care.

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Structured Pretravel Advice Should Be Provided to Patients

THURSDAY, July 21, 2016 (HealthDay News) -- Structured advice should be provided to individuals planning to travel internationally, according to a review article published in the July 21 issue of the New England Journal of Medicine.

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Implant Non-Inferior to Daily Pill for Opioid Dependence

WEDNESDAY, July 20, 2016 (HealthDay News) -- Patients addicted to opioids are more likely to overcome their dependence if they receive a new long-acting implant rather than a daily treatment pill, according to a study published in the July 19 issue of the Journal of the American Medical Association.

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ACS Endorses CDC's HPV Vaccine Guidelines

WEDNESDAY, July 20, 2016 (HealthDay News) -- The American Cancer Society has endorsed the U.S. government's HPV vaccination recommendations, which include immunizing all preteens against human papillomavirus (HPV). The report was published online July 19 in CA: A Cancer Journal for Clinicians.

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Medicare Spending Up for Decedents Versus Survivors

WEDNESDAY, July 20, 2016 (HealthDay News) -- Medicare per capita spending was much higher for beneficiaries who died during 2014 than for those who survived the entire year, according to a report published by the Kaiser Family Foundation.

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Diabetes Meds Deemed Equal, but Metformin Still First-Line

WEDNESDAY, July 20, 2016 (HealthDay News) -- There are no significant differences in the associations between available glucose-lowering drugs (alone or in combination) and the risk of cardiovascular or all-cause mortality, according to a review published in the July 19 issue of the Journal of the American Medical Association.

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IVF Treatment Does Not Appear to Increase Breast Cancer Risk

WEDNESDAY, July 20, 2016 (HealthDay News) -- Women who undergo in vitro fertilization (IVF) are not at increased risk of breast cancer, according to a study published in the July 19 issue of the Journal of the American Medical Association.

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Review Examines Topical Complementary Meds in Eczema

WEDNESDAY, July 20, 2016 (HealthDay News) -- For patients with atopic eczema (AE), six studies assessing topical complementary and alternative medicines display superiority to placebo but only two (licorice gel and Hypericum perforatum) have low risk of bias on all domains, according to a review published online July 4 in the British Journal of Dermatology.

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Global Fight Against HIV Remains Challenging

TUESDAY, July 19, 2016 (HealthDay News) -- The number of HIV/AIDS deaths worldwide each year has fallen since peaking in 2005, but the number of new HIV infections is up in 74 countries, according to a study published online July 19 in The Lancet HIV to coincide with the 21st International AIDS Conference, held from July 18 to 22 in Durban, South Africa.

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Labor Compensation, Purchased Goods, Service Biggest Spends

TUESDAY, July 19, 2016 (HealthDay News) -- Labor compensation remains the single largest contributor to costs among physicians' offices, hospitals, and outpatient care centers, according to a report published in the July issue of Health Affairs.

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Burnout Can Have Acute Personal, Professional Consequences

MONDAY, July 18, 2016 (HealthDay News) -- Stress and burnout are increasingly prevalent among physicians, with serious personal and professional consequences, according to a report published in Medical Economics.

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Baseline Depression Symptoms Tied to Low Med Adherence

MONDAY, July 18, 2016 (HealthDay News) -- Among clinical and sociodemographic characteristics, only baseline depressive symptoms are tied to low medication adherence in teen patients with type 2 diabetes, according to a study published online June 28 in Diabetes Care.

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Baseline ALT, AST Frequently Assessed With Statin Initiation

MONDAY, July 18, 2016 (HealthDay News) -- Most Medicare fee-for-service beneficiaries with dyslipidemia who initiate statins undergo baseline alanine aminotransferase (ALT) and aspartate aminotransferase (AST) testing, according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

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Biologic Response Modifier Use in Kids Ups Infectious Complications

MONDAY, July 18, 2016 (HealthDay News) -- For pediatric patients, the use of biologic response modifiers (BRMs) is associated with increased risk of infectious complications, according to a clinical report published online July 18 in Pediatrics.

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Growth in U.S. Health Spending Set to Average 5.8 Percent

FRIDAY, July 15, 2016 (HealthDay News) -- Growth in U.S. health spending is expected to average 5.8 percent for 2015 to 2025, according to a study published in the July issue of Health Affairs.

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Increase in Acute Synthetic Cannabinoid Poisonings

FRIDAY, July 15, 2016 (HealthDay News) -- Synthetic cannabinoids are sending increasing numbers of U.S. users to hospitals, according to research published in the July 15 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Antibiotic-Resistant Gonorrhea on the Rise in the United States

FRIDAY, July 15, 2016 (HealthDay News) -- Antibiotic-resistant cases of gonorrhea have more than quadrupled in the United States, according to research published in the July 15 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Quality Improvement Strategy Ups Achievement of T2DM Goals

FRIDAY, July 15, 2016 (HealthDay News) -- A multicomponent quality improvement (QI) strategy can improve achievement of diabetes care goals in a population of type 2 diabetes patients with poor cardiometabolic profiles, according to a study published online July 12 in the Annals of Internal Medicine.

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Pre-Op Patterns Can Predict Post-Cardiac Surgery Constipation

FRIDAY, July 15, 2016 (HealthDay News) -- For patients undergoing cardiac surgery, preoperative constipation patterns are associated with postoperative constipation patterns, according to a study published online July 12 in the Journal of Clinical Nursing.

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Metamizole Could Be Alternative to Classical NSAIDs

THURSDAY, July 14, 2016 (HealthDay News) -- Metamizole seems to be safer than other nonsteroidal anti-inflammatory drugs (NSAIDs) and causes fewer gastric and duodenal ulcers in postoperative pain management, according to a review published online June 27 in Pain Practice.

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Lidocaine/Prilocaine Optimal for Deeper Dermal Laser Procedures

THURSDAY, July 14, 2016 (HealthDay News) -- For patients undergoing deeper dermal laser treatments of acne keloidalis nuchae (AKN) and tattoos, lidocaine/prilocaine cream is better for reducing pain than lidocaine/tetracaine cream, according to a study published online July 5 in the British Journal of Dermatology.

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Recommendations Updated for Use of Antiretroviral Tx in HIV

WEDNESDAY, July 13, 2016 (HealthDay News) -- Recommendations for the use of antiretroviral therapy in HIV infection have been updated for adults, and published in the July 12 issue of the Journal of the American Medical Association, a theme issue on HIV/AIDS.

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Antibiotic Exposure Linked to Increased Odds of Child Obesity

WEDNESDAY, July 13, 2016 (HealthDay News) -- Antibiotic exposure is associated with increased odds of obesity among young children, according to a study published in the July issue of Gastroenterology.

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Small HIV Infection Risk in Condomless Sex With Use of ART

WEDNESDAY, July 13, 2016 (HealthDay News) -- HIV transmission is highly unlikely among heterosexual couples who have sex without condoms when one partner carries the virus but takes antiretroviral therapy, according to a study published in the July 12 issue of the Journal of the American Medical Association, a theme issue on HIV/AIDS.

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Possible Benefit for Addition of Cetuximab to RT in Laryngeal CA

WEDNESDAY, July 13, 2016 (HealthDay News) -- For patients with hypopharyngeal or laryngeal carcinoma, the addition of cetuximab to radiotherapy is associated with a nonsignificant improvement in laryngeal preservation and laryngectomy-free survival, according to a study published online July 7 in JAMA Otolaryngology-Head & Neck Surgery.

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Nilotinib Shows Early Promise for Parkinson's Disease

WEDNESDAY, July 13, 2016 (HealthDay News) -- A drug used to treat leukemia, nilotinib, has shown initial signs of promise for advanced cases of Parkinson's disease, according to a study published online July 11 in the Journal of Parkinson's Disease.

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FDA Approves Xiidra Eye Drops to Treat Dry Eye Disease

TUESDAY, July 12, 2016 (HealthDay News) -- Xiidra (lifitegrast) eye drops have been approved by the U.S. Food and Drug Administration to treat symptoms of dry eye disease.

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Review: Yoga Benefits Patients With Type 2 Diabetes

TUESDAY, July 12, 2016 (HealthDay News) -- Yoga benefits adult patients with type 2 diabetes mellitus (T2DM), according to a review published online July 1 in the Journal of Diabetes Investigation.

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Recommendations Updated for H. pylori Treatment in Adults

TUESDAY, July 12, 2016 (HealthDay News) -- Recommendations have been updated for treatment of Helicobacter pylori in adults, according to a consensus statement published in the July issue of Gastroenterology.

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Many Adults 'Hoarding,' Self-Prescribing Antibiotics

TUESDAY, July 12, 2016 (HealthDay News) -- One in every 20 adults have used antibiotics without a doctor's guidance, according to a study published online July 11 in Antimicrobial Agents and Chemotherapy.

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Second U.S. Case of Bacteria Resistant to Colistin

TUESDAY, July 12, 2016 (HealthDay News) -- Scientists have identified a second patient in the United States who was infected with a bacteria that is resistant to an antibiotic of last resort. The findings were published online July 11 in Antimicrobial Agents and Chemotherapy.

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FDA Approves Differin Gel for Over-the-Counter Use

MONDAY, July 11, 2016 (HealthDay News) -- The once-daily acne treatment Differin Gel 0.1% (adapalene) has been approved for over-the-counter use among patients 12 and older, the U.S. Food and Drug Administration said.

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Medication Organization Devices Tied to Adverse Effects

MONDAY, July 11, 2016 (HealthDay News) -- Medication organization devices (MODs) may cause medication-related adverse events in unintentionally nonadherent older people, according to a study published online July 5 in Health Technology Assessment.

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Triple Therapy Rarely Used for Rheumatoid Arthritis Patients

MONDAY, July 11, 2016 (HealthDay News) -- Patients with rheumatoid arthritis (RA) rarely use triple therapy (methotrexate, sulfasalazine, and hydroxychloroquine), according to a study published in the July issue of Arthritis & Rheumatology.

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Doxycycline Helps One-Third of Chronic Cold Urticaria Patients

MONDAY, July 11, 2016 (HealthDay News) -- Just over one-third of chronic cold urticaria patients benefit from treatment with doxycycline, according to a research letter published online June 25 in the British Journal of Dermatology.

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No Response to First Antifungals Tied to Worse Keratitis Outcomes

MONDAY, July 11, 2016 (HealthDay News) -- Fungal keratitis patients pretreated with antifungal medication appear to have worse outcomes, according to a study published online June 21 in Clinical & Experimental Ophthalmology.

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Emetine Shows Promise for Human Cytomegalovirus Infection

MONDAY, July 11, 2016 (HealthDay News) -- Emetine may represent a therapeutic option for human cytomegalovirus (HCMV) infection, according to a study published in the June issue of PLOS Pathogens.

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Health Care Costs ~60 Percent Higher for Obese Preschoolers

FRIDAY, July 8, 2016 (HealthDay News) -- In addition to the health impacts of childhood obesity, there are major economic impacts, which may occur earlier than previously thought, according to research published online July 6 in Obesity.

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Retinoblastoma Mortality Up With Eye-Preserving Radiotherapy

FRIDAY, July 8, 2016 (HealthDay News) -- Short-term survival of heritable retinoblastoma is high, but long-term mortality remains a challenge, according to a study published online July 5 in the Journal of Clinical Oncology.

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VA Appealing to Physicians to Join Agency

FRIDAY, July 6, 2016 (HealthDay News) -- The U.S. Department of Veterans Affairs (VA) is appealing to physicians to join the agency as part of its recovery from a 2014 scandal linked to excessive wait times, according to a report published by the American Medical Association.

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Medical Marijuana Laws Affect Medicare Part D Spending

FRIDAY, July 8, 2016 (HealthDay News) -- Legalization of medical marijuana and its associated availability have affected prescribing patterns and spending in Medicare Part D, according to a study published online July 6 in Health Affairs.

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Patient Variables Not Linked to Hemoglobin A1c Targets

FRIDAY, July 8, 2016 (HealthDay News) -- Patient variables seem not to be associated with hemoglobin A1c (HbA1c) targets, according to a study published online June 22 in Diabetes Care.

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CDC: Majority of HPV-Linked Cancers Are Preventable

FRIDAY, July 8, 2016 (HealthDay News) -- The majority of cancers linked to human papillomavirus (HPV) are preventable, according to a report published in the July 8 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Pharmacists Report Hidden Fees That Distort Prescription Costs

THURSDAY, July 7, 2016 (HealthDay News) -- Pharmacists often encounter fees imposed by prescription drug "middlemen" that adversely impact both pharmacies and patients and distort medication costs and reimbursement rates, according to a report from the National Community Pharmacists Association (NCPA).

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Relamorelin Beneficial in Adults With Diabetic Gastroparesis

THURSDAY, July 7, 2016 (HealthDay News) -- For adults with diabetic gastroparesis, relamorelin reduces vomiting frequency and severity and accelerates gastric emptying, according to a study published in the July issue of Gastroenterology.

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Lab-Established Diagnosis Key for Persistent Diarrhea

THURSDAY, July 7, 2016 (HealthDay News) -- Persistent diarrhea is typically caused by parasites or bacteria and requires accurate diagnosis in order to determine appropriate treatment, according to a review published online June 28 in the Journal of the American Medical Association.

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Case Vignette Addresses Diagnosis, Management of PCOS

THURSDAY, July 7, 2016 (HealthDay News) -- The diagnosis and management of polycystic ovary syndrome is discussed in a case vignette published online July 6 in The New England Journal of Medicine.

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Neratinib Active in HER2-Positive, HR-Negative Breast Cancer

THURSDAY, July 7, 2016 (HealthDay News) -- Neratinib and veliparib-carboplatin appear to be effective in women with specific subtypes of breast cancer, according to two studies published online July 6 in The New England Journal of Medicine.

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Several Factors Impact Parent Management of Child Postop Pain

WEDNESDAY, July 6, 2016 (HealthDay News) -- Several factors impact parents' management of their children's postoperative pain at home, according to a study published online June 27 in the Journal of Clinical Nursing.

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U.S. Medical Schools to Expand Training on Opioid Abuse

WEDNESDAY, July 6, 2016 (HealthDay News) -- U.S. medical schools are expanding training to address the increasing number of overdose deaths, according to a report published by The Associated Press.

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Deutetrabenazine Improves Motor Signs in Huntington's

WEDNESDAY, July 6, 2016 (HealthDay News) -- Deutetrabenazine results in improved motor signs at 12 weeks among patients with chorea associated with Huntington's disease, according to a study published online July 5 in the Journal of the American Medical Association.

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Many Clinical Trials Are Not Listed in Data-Sharing Repository

WEDNESDAY, July 6, 2016 (HealthDay News) -- Only about half of trials registered at ClinicalTrials.gov are listed in the largest data-sharing repository, according to a research letter published online June 28 in the Journal of the American Medical Association.

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CVD Risks Way Up in Familial Hypercholesterolemia

TUESDAY, July 5, 2016 (HealthDay News) -- Patients with heterozygous familial hypercholesterolemia (FH) have a significantly increased risk for coronary heart disease (CHD) and atherosclerotic cardiovascular disease (ASCVD), according to research published online June 29 in Circulation.

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Mindful Self-Compassion Program Beneficial in Diabetes

TUESDAY, July 5, 2016 (HealthDay News) -- A mindful self-compassion (MSC) program can reduce depression, diabetes-specific distress, and glycated hemoglobin (HbA1c) levels in patients with diabetes, according to a study published online June 22 in Diabetes Care.

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U.S. Cancer Survivors Aging, Battling Other Chronic Disease

FRIDAY, July 1, 2016 (HealthDay News) -- In 2016, nearly 62 percent of almost 16 million cancer survivors are aged 65 or older; and, by 2040, an estimated 73 percent of 26 million cancer survivors will be 65 or older, according to a report published in the July 1 issue of Cancer Epidemiology, Biomarkers & Prevention.

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Several Treatments Efficacious for Binge-Eating Disorder

FRIDAY, July 1, 2016 (HealthDay News) -- Patients struggling with binge-eating disorder have several efficacious treatment options available, according to a review published online June 28 in the Annals of Internal Medicine.

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Hundreds of U.S. Clinics Sell Unapproved Stem Cell 'Therapies'

FRIDAY, July 1, 2016 (HealthDay News) -- Hundreds of clinics across the United States are marketing unapproved stem cell treatments for conditions ranging from aging skin to spinal cord injuries, according to a study published online June 30 in Cell Stem Cell.

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Fludrocortisone Linked to Reduction in Vasovagal Syncope

FRIDAY, July 1, 2016 (HealthDay News) -- Fludrocortisone is associated with a reduction in the risk of vasovagal syncope, according to a study published in the July 5 issue of the Journal of the American College of Cardiology.

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Extended-Spectrum Antibiotics No Benefit for Pediatric Appendicitis

FRIDAY, July 1, 2016 (HealthDay News) -- For children diagnosed with appendicitis undergoing appendectomy, extended-spectrum antibiotics seem to offer no advantage over narrower-spectrum agents, according to a study published online June 28 in Pediatrics.

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Glucagon-Like Peptide-1 Receptor Agonists Beneficial As Add-On

FRIDAY, July 1, 2016 (HealthDay News) -- Lixisenatide and glulisine as add-on to basal insulin result in a reduction in glycated hemoglobin (HbA1c) levels in patients with type 2 diabetes, according to a study published online June 22 in Diabetes Care.

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