July 2016 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for July 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Exercising One Hour/Day May Eliminate Sitting's Toll on Health

FRIDAY, July 29, 2016 (HealthDay News) -- Just one hour of physical activity a day -- something as simple as a brisk walk or a bicycle ride -- may undo the increased mortality risk that comes with sitting eight hours or more on a daily basis, according to research published online July 27 in The Lancet.

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Fracture Risk Up for Patients Undergoing Bariatric Surgery

FRIDAY, July 29, 2016 (HealthDay News) -- Patients undergoing bariatric surgery have increased risk of fracture, according to a study published online July 28 in the BMJ.

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About One in Five Have Recurrent Diabetic Ketoacidosis

FRIDAY, July 29, 2016 (HealthDay News) -- Recurrent diabetic ketoacidosis (DKA) is common, occurring in more than one in five patients, according to a study published online July 15 in Diabetes Care.

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FDA Approves Adlyxin for Type 2 Diabetes Mellitus

THURSDAY, July 28, 2016 (HealthDay News) -- Adlyxin (lixisenatide), a glucagon-like peptide-1 receptor agonist, has been approved by the U.S. Food and Drug Administration to treat type 2 diabetes in adults, the agency said Thursday in a news release.

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Even Moderate Exercise Can Reduce Risk of Gestational DM

THURSDAY, July 28, 2016 (HealthDay News) -- Obese pregnant women can reduce their risk of gestational diabetes and lower their blood pressure by exercising as little as three times a week, according to a study published online July 26 in PLOS Medicine.

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Brachial-Ankle Pulse Wave Velocity Can Predict Mortality

THURSDAY, July 28, 2016 (HealthDay News) -- Brachial-ankle pulse wave velocity (baPWV) can predict all-cause mortality in patients with diabetes after first non-traumatic lower extremity amputation (LEA), according to a study published online July 16 in the Journal of Diabetes Investigation.

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Blunted, More Variable Insulin Action in Lipohypertrophy

WEDNESDAY, July 27, 2016 (HealthDay News) -- Insulin lispro injection into lipohypertrophic tissue (LHT) results in considerable impairment and increased variability in insulin absorption and action, according to a study published in online July 13 in Diabetes Care.

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Flu Vaccine Protective Against Hospitalization, Death in T2DM

WEDNESDAY, July 27, 2016 (HealthDay News) -- The seasonal influenza vaccine may significantly reduce mortality for patients with type 2 diabetes, as well as hospitalizations for stroke and cardiovascular and pulmonary issues, according to a study published online July 25 in CMAJ, the journal of the Canadian Medical Association.

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American Red Cross Says Blood Donations Needed Urgently

TUESDAY, July 26, 2016 (HealthDay News) -- The American Red Cross says it has an urgent need for blood donations, with less than a five-day supply of blood on hand to help those who need it.

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Medical Students Often Track Progress of Former Patients

TUESDAY, July 26, 2016 (HealthDay News) -- Many U.S. medical students use electronic health records to track the progress of their former patients and confirm the accuracy of their diagnoses, according to research letter published online July 25 in JAMA Internal Medicine.

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Sex-Specific Role for Glucokinase in Autonomic Nervous Activity

TUESDAY, July 26, 2016 (HealthDay News) -- Glucokinase (Gck) in the ventromedial hypothalamic nucleus (VMN) is involved in glucose-dependent control of autonomic nervous activity in female mice only, according to an experimental study published online July 15 in Diabetes.

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'Walking Meetings' Feasible Strategy for Employee Wellness

MONDAY, July 25, 2016 (HealthDay News) -- Converting a single weekly meeting to a walking meeting can help raise work-related physical activity levels of white-collar workers, according to a report published online June 23 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Program Can Help Patient-Centered Practice Transition

FRIDAY, July 22, 2016 (HealthDay News) -- A new study describes a scalable solution for transforming health care delivery in primary care into the patient-centered medical home model. The report was published online July 15 in the Journal of Cognitive Engineering and Decision Making.

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Severe Hypoglycemia Linked to Mortality, CVD Events in T1DM

FRIDAY, July 22, 2016 (HealthDay News) -- For patients with type 1 diabetes mellitus (T1DM), severe hypoglycemia is associated with increased risk of all-cause mortality and cardiovascular disease (CVD), according to research published online July 6 in Diabetes Care.

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Overall Mortality Similar in DCCT/EDIC, General Population

FRIDAY, July 22, 2016 (HealthDay News) -- Overall mortality is similar in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study cohort and the general population, according to a study published online July 13 in Diabetes Care.

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Imaging Post-Thyroid Cancer Treatment Doesn't Always Benefit

THURSDAY, July 21, 2016 (HealthDay News) -- More imaging tests after treatment does not always lead to an improvement in thyroid cancer patients' chances of survival, according to a study published online July 20 in The BMJ.

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Health Expenditures Rising for Middle Class, Wealthy

THURSDAY, July 21, 2016 (HealthDay News) -- While overall U.S. medical spending growth slowed between 2004 and 2013, expenditures rose for middle- and high-income Americans, according to research published in the July issue of Health Affairs.

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Walking Briskly May Outperform Jogging in Prediabetes

THURSDAY, July 21, 2016 (HealthDay News) -- Brisk walking may be more effective than jogging in controlling blood glucose levels in patients with prediabetes, according to a study published online July 15 in Diabetologia.

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Drug Shows Promise for Genetic Proopiomelanocortin Deficiency

THURSDAY, July 21, 2016 (HealthDay News) -- An experimental drug spurred substantial weight loss in patients with proopiomelanocortin (POMC) deficiency, according to a study published in the July 21 issue of the New England Journal of Medicine.

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Estradiol Doesn't Boost Cognitive Function After Menopause

THURSDAY, July 21, 2016 (HealthDay News) -- Improvement in cognitive ability is not associated with estrogen therapy among women who use it after menopause, no matter when they start taking it, according to a study published online July 15 in Neurology.

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Structured Pretravel Advice Should Be Provided to Patients

THURSDAY, July 21, 2016 (HealthDay News) -- Structured advice should be provided to individuals planning to travel internationally, according to a review article published in the July 21 issue of the New England Journal of Medicine.

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Buprenorphine May Be Helpful in Peripheral Neuropathic Pain

THURSDAY, July 21, 2016 (HealthDay News) -- For patients with moderate to severe diabetic peripheral neuropathic pain (DPNP), transdermal buprenorphine is effective for reducing pain, but is associated with adverse events, according to a study published online June 16 in Diabetes Care.

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Diabetes Rates for U.S. Teens Higher Than Previously Reported

WEDNESDAY, July 20, 2016 (HealthDay News) -- More American teens have diabetes or prediabetes than previously thought, and many don't know they have the condition, according to a research letter published in the July 19 issue of the Journal of the American Medical Association.

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Medicare Spending Up for Decedents Versus Survivors

WEDNESDAY, July 20, 2016 (HealthDay News) -- Medicare per capita spending was much higher for beneficiaries who died during 2014 than for those who survived the entire year, according to a report published by the Kaiser Family Foundation.

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Diabetes Confers Worse Prognosis for Patients With ACS

WEDNESDAY, July 20, 2016 (HealthDay News) -- For patients with acute coronary syndromes (ACS), diabetes confers a worse prognosis, according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

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IVF Treatment Does Not Appear to Increase Breast Cancer Risk

WEDNESDAY, July 20, 2016 (HealthDay News) -- Women who undergo in vitro fertilization (IVF) are not at increased risk of breast cancer, according to a study published in the July 19 issue of the Journal of the American Medical Association.

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Diabetes Meds Deemed Equal, but Metformin Still First-Line

WEDNESDAY, July 20, 2016 (HealthDay News) -- There are no significant differences in the associations between available glucose-lowering drugs (alone or in combination) and the risk of cardiovascular or all-cause mortality, according to a review published in the July 19 issue of the Journal of the American Medical Association.

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High-Fat Mediterranean Diet Can Still Be Healthy

TUESDAY, July 19, 2016 (HealthDay News) -- Even a high-fat Mediterranean diet may protect against breast cancer, diabetes, and cardiovascular disease, according to a review published online July 19 in the Annals of Internal Medicine.

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AAP Urges Awareness of Female Athlete Triad

TUESDAY, July 19, 2016 (HealthDay News) -- Physicians should be aware of the "female athlete triad," which includes amenorrhea, osteoporosis, and disordered eating, according to the American Academy of Pediatrics. The report was published online July 18 in Pediatrics.

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Proinsulin-to-C-Peptide Ratio Linked to Progression to T1DM

TUESDAY, July 19, 2016 (HealthDay News) -- Elevation in the serum proinsulin-to-C-peptide (PI:C) ratio is associated with progression to type 1 diabetes, according to a study published online July 6 in Diabetes Care.

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Labor Compensation, Purchased Goods, Service Biggest Spends

TUESDAY, July 19, 2016 (HealthDay News) -- Labor compensation remains the single largest contributor to costs among physicians' offices, hospitals, and outpatient care centers, according to a report published in the July issue of Health Affairs.

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Burnout Can Have Acute Personal, Professional Consequences

MONDAY, July 18, 2016 (HealthDay News) -- Stress and burnout are increasingly prevalent among physicians, with serious personal and professional consequences, according to a report published in Medical Economics.

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Baseline Depression Symptoms Tied to Low Med Adherence

MONDAY, July 18, 2016 (HealthDay News) -- Among clinical and sociodemographic characteristics, only baseline depressive symptoms are tied to low medication adherence in teen patients with type 2 diabetes, according to a study published online June 28 in Diabetes Care.

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Growth in U.S. Health Spending Set to Average 5.8 Percent

FRIDAY, July 15, 2016 (HealthDay News) -- Growth in U.S. health spending is expected to average 5.8 percent for 2015 to 2025, according to a study published in the July issue of Health Affairs.

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Red Meat Intake Linked to Increased Risk of ESRD

FRIDAY, July 15, 2016 (HealthDay News) -- Red meat intake is associated with increased risk of end-stage renal disease (ESRD), according to a study published online July 14 in the Journal of the American Society of Nephrology.

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Review: Plant-Based Diets Tied to Improved Inflammatory Profiles

FRIDAY, July 15, 2016 (HealthDay News) -- Plant-based diets are associated with improvement in obesity-related inflammatory biomarker profiles, including decreases in C-reactive protein and interleukin-6 levels, according to a review published online July 13 in Obesity Reviews.

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Quality Improvement Strategy Ups Achievement of T2DM Goals

FRIDAY, July 15, 2016 (HealthDay News) -- A multicomponent quality improvement (QI) strategy can improve achievement of diabetes care goals in a population of type 2 diabetes patients with poor cardiometabolic profiles, according to a study published online July 12 in the Annals of Internal Medicine.

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Three-Year Delays Seen in First Referral for Diabetic Retinopathy

FRIDAY, July 15, 2016 (HealthDay News) -- An average delay of 3.1 years for an initial diabetes eye exam was found in a recent Australian study. The findings were published online in a letter to the editor June 27 in Clinical & Experimental Ophthalmology.

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Prediabetes for One in Five Healthy-Weight Americans

THURSDAY, July 14, 2016 (HealthDay News) -- Nearly one in five healthy-weight Americans have prediabetes, with numbers rising with increasing age, according to a study published in the July/August issue of the Annals of Family Medicine.

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Supreme Court Ruling Could Impact Med School Admissions

THURSDAY, July 14, 2016 (HealthDay News) -- The U.S. Supreme Court's ruling upholding the University of Texas at Austin's consideration of race and ethnicity in college admissions has implications for medical schools, according to the American Medical Association (AMA).

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CV Autonomic Neuropathy Tied to Sexual Dysfunction, Incontinence

THURSDAY, July 14, 2016 (HealthDay News) -- Among women with type 1 diabetes mellitus (T1DM) there are increased odds of female sexual dysfunction (FSD) and urinary incontinence (UI) associated with specific measures of cardiovascular autonomic neuropathy (CAN), according to a study published online June 28 in Diabetes Care.

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Dysglycemia on the Rise in Obese American Adults

THURSDAY, July 14, 2016 (HealthDay News) -- Among obese American adults, dysglycemia is worsening, leading to more diabetes and cardiovascular disease, according to a study published online July 13 in the Journal of the American Heart Association.

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Differences in Salary for Male, Female Faculty Physicians

WEDNESDAY, July 13, 2016 (HealthDay News) -- For physicians with faculty appointments at 24 U.S. public medical schools there are significant salary differences between men and women, even after adjustment for confounding variables, according to a study published online July 11 in JAMA Internal Medicine.

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One Week of Bed Rest Lowers Muscle Mass, Insulin Sensitivity

WEDNESDAY, July 13, 2016 (HealthDay News) -- One week of bed rest is associated with a substantial reduction in skeletal muscle mass and decreased whole-body insulin sensitivity, according to a study published online June 29 in Diabetes.

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Depression Linked to CKD in Patients With Diabetes

WEDNESDAY, July 13, 2016 (HealthDay News) -- For patients with diabetes, the presence of depression is associated with increased risk of developing chronic kidney disease (CKD), according to a study published online June 16 in Diabetes Care.

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Inadequate Hydration Linked to Higher Odds of Obesity

TUESDAY, July 12, 2016 (HealthDay News) -- Staying adequately hydrated may be associated with a lower risk of obesity, according to a study published in the July/August issue of the Annals of Family Medicine.

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Review: Yoga Benefits Patients With Type 2 Diabetes

TUESDAY, July 12, 2016 (HealthDay News) -- Yoga benefits adult patients with type 2 diabetes mellitus (T2DM), according to a review published online July 1 in the Journal of Diabetes Investigation.

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Medication Organization Devices Tied to Adverse Effects

MONDAY, July 11, 2016 (HealthDay News) -- Medication organization devices (MODs) may cause medication-related adverse events in unintentionally nonadherent older people, according to a study published online July 5 in Health Technology Assessment.

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Autonomic Function Tied to Coronary Flow Reserve in T2DM

MONDAY, July 11, 2016 (HealthDay News) -- Impaired cardiac autonomic function is associated with coronary flow reserve (CFR) in patients with type 2 diabetes, according to a study published in the June issue of Diabetes.

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Health Care Costs ~60 Percent Higher for Obese Preschoolers

FRIDAY, July 8, 2016 (HealthDay News) -- In addition to the health impacts of childhood obesity, there are major economic impacts, which may occur earlier than previously thought, according to research published online July 6 in Obesity.

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VA Appealing to Physicians to Join Agency

FRIDAY, July 6, 2016 (HealthDay News) -- The U.S. Department of Veterans Affairs (VA) is appealing to physicians to join the agency as part of its recovery from a 2014 scandal linked to excessive wait times, according to a report published by the American Medical Association.

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Patient Variables Not Linked to Hemoglobin A1c Targets

FRIDAY, July 8, 2016 (HealthDay News) -- Patient variables seem not to be associated with hemoglobin A1c (HbA1c) targets, according to a study published online June 22 in Diabetes Care.

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Metabolomics Signature Can Predict GDM to T2DM Transition

THURSDAY, June 30, 2016 (HealthDay News) -- A metabolomics signature can predict the transition from gestational diabetes mellitus (GDM) to type 2 diabetes (T2D), according to a study published online June 23 in Diabetes.

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Diabetic Retinopathy Independently Tied to Depression

THURSDAY, July 7, 2016 (HealthDay News) -- Severe nonproliferative diabetic retinopathy (NPDR) or PDR, but not diabetic macular edema (DME), is associated with depressive symptoms, according to a study published online July 7 in JAMA Ophthalmology.

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Case Vignette Addresses Diagnosis, Management of PCOS

THURSDAY, July 7, 2016 (HealthDay News) -- The diagnosis and management of polycystic ovary syndrome is discussed in a case vignette published online July 6 in The New England Journal of Medicine.

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Relamorelin Beneficial in Adults With Diabetic Gastroparesis

THURSDAY, July 7, 2016 (HealthDay News) -- For adults with diabetic gastroparesis, relamorelin reduces vomiting frequency and severity and accelerates gastric emptying, according to a study published in the July issue of Gastroenterology.

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Many Clinical Trials Are Not Listed in Data-Sharing Repository

WEDNESDAY, July 6, 2016 (HealthDay News) -- Only about half of trials registered at ClinicalTrials.gov are listed in the largest data-sharing repository, according to a research letter published online June 28 in the Journal of the American Medical Association.

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Diabetes Impacts QOL Outcome After Lumbar Decompression

WEDNESDAY, July 6, 2016 (HealthDay News) -- Diabetes predicts diminished quality of life (QOL) improvements after lumbar decompression surgery, according to a study published in the June issue of The Spine Journal.

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Obesity Tied to Consumption of U.S. Subsidy Crops

WEDNESDAY, July 6, 2016 (HealthDay News) -- Americans get more than half of their daily calories from seven farm foods that are subsidized by the U.S. government, but a new study suggests those subsidies may be contributing to the obesity epidemic. The findings were published online July 5 in JAMA Internal Medicine.

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Genetic Risk Score Impact on BMI Varies Across Birth Cohorts

WEDNESDAY, July 6, 2016 (HealthDay News) -- The magnitude of the association between a multilocus genetic risk score for body mass index (GRS-BMI) and BMI is larger for individuals born in later birth cohorts, according to a study published online July 5 in the Journal of the American Medical Association.

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Mindful Self-Compassion Program Beneficial in Diabetes

TUESDAY, July 5, 2016 (HealthDay News) -- A mindful self-compassion (MSC) program can reduce depression, diabetes-specific distress, and glycated hemoglobin (HbA1c) levels in patients with diabetes, according to a study published online June 22 in Diabetes Care.

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Elevated Risk of Death for Osteogenesis Imperfecta

TUESDAY, July 5, 2016 (HealthDay News) -- Patients with osteogenesis imperfecta (OI) have an elevated risk of death, according to a study published online June 27 in the Journal of Bone and Mineral Research.

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U.S. Cancer Survivors Aging, Battling Other Chronic Disease

FRIDAY, July 1, 2016 (HealthDay News) -- In 2016, nearly 62 percent of almost 16 million cancer survivors are aged 65 or older; and, by 2040, an estimated 73 percent of 26 million cancer survivors will be 65 or older, according to a report published in the July 1 issue of Cancer Epidemiology, Biomarkers & Prevention.

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Obesity Prevalent in Military Service Members, Veterans

FRIDAY, July 1, 2016 (HealthDay News) -- One in five U.S. military service members are obese, according to a study published in the July issue of Obesity.

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Glucagon-Like Peptide-1 Receptor Agonists Beneficial As Add-On

FRIDAY, July 1, 2016 (HealthDay News) -- Lixisenatide and glulisine as add-on to basal insulin result in a reduction in glycated hemoglobin (HbA1c) levels in patients with type 2 diabetes, according to a study published online June 22 in Diabetes Care.

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