July 2015 Briefing - Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for July 2015. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

AMA Wants Doctor Input on EHRs, Meaningful Use

FRIDAY, July 31, 2015 (HealthDay News) -- The American Medical Association (AMA) is encouraging clinicians to share their perspectives on electronic heath records (EHRs) and the meaningful use program.

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Accuracy, Timing of Pre-Op Lung CA Evaluation Can Be Improved

FRIDAY, July 31, 2015 (HealthDay News) -- For suspected lung cancer patients, the thoroughness, accuracy, and timeliness of preoperative evaluation could be improved, according to research published online July 30 in the Annals of Thoracic Surgery.

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U.S. Health Spending Projected to Rise 5.8 Percent By 2024

FRIDAY, July 31, 2015 (HealthDay News) -- From 2014 to 2024, U.S. health spending growth is projected to increase by about 6 percent, according to a report published online July 28 in Health Affairs.

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Test Set Performance Indicators Correlate Well With Clinical Audit

FRIDAY, July 31, 2015 (HealthDay News) -- Some performance indicators for mammography test sets are associated with aspects of clinical audit parameters, according to a study published in the August issue of the Journal of Medical Imaging and Radiation Oncology.

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Tyrosine Kinase Inhibitors Seem Safe in CML With CKD

FRIDAY, July 31, 2015 (HealthDay News) -- Tyrosine kinase inhibitors (TKIs) appear to be safe in patients with chronic-phase (CP) chronic myeloid leukemia (CML) and chronic kidney disease (CKD), according to a study published online July 28 in Cancer.

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HPV16 DNA in Oral Rinses at Oropharyngeal Cancer Diagnosis

THURSDAY, July 30, 2015 (HealthDay News) -- Human papillomavirus (HPV) type 16 DNA in oral rinses is common at diagnosis of HPV-related oropharyngeal carcinoma (HPV-OPC), according to a study published online July 30 in JAMA Oncology.

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U.S. Medical Groups Fighting Prescription Opioid Abuse

THURSDAY, July 30, 2015 (HealthDay News) -- Led by the American Medical Association (AMA), a group of 27 major U.S. medical organizations are banding together to tackle the continuing epidemic of opioid abuse.

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Telomere Length May Help Predict Lung Cancer Risk

THURSDAY, July 30, 2015 (HealthDay News) -- Individuals with long telomeres are at increased risk for lung adenocarcinoma but not other types of cancer, according to a study published online July 2 in Human Molecular Genetics.

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New Rx for Myeloid Malignancies Moves to Phase II Clinical Trials

WEDNESDAY, July 29, 2015 (HealthDay News) -- The selective Hedgehog antagonist PF-04449913 seems safe and is tolerated in adults with myeloid malignancies, according to a study published online July 26 in The Lancet Haematology.

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Novel Microendoscope Ups Accuracy of Esophageal Screening

WEDNESDAY, July 29, 2015 (HealthDay News) -- A novel, low-cost, high-resolution microendoscope (HRME) improves the accuracy of Lugol's chromoendoscopy (LCE) for screening and surveillance of esophageal squamous cell neoplasia, according to a study published in the August issue of Gastroenterology.

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RAPID Score Validated for Prognosis of Pleural Infections

WEDNESDAY, July 29, 2015 (HealthDay News) -- The recently developed RAPID score, which identifies the risk of mortality in patients with pleural infections based on five clinical factors, has been validated in a diverse patient cohort. The findings have been published online July 20 in the Annals of the American Thoracic Society.

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2015 MOC Program Expected to Cost $5.7 Billion Over 10 Years

WEDNESDAY, July 29, 2015 (HealthDay News) -- The 2015 version of the American Board of Internal Medicine (ABIM) maintenance-of-certification (MOC) program is expected to generate considerable costs, mainly due to physician time costs, according to research published online July 28 in the Annals of Internal Medicine.

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Patients Report Improved Care Access, Better Health With ACA

TUESDAY, July 28, 2015 (HealthDay News) -- Millions more Americans have affordable health insurance, access to a personal doctor, and feel they are in better health following the first two open-enrollment periods of the Affordable Care Act (ACA), a new analysis shows. The results are published in the July 28 issue of the Journal of the American Medical Association.

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ASCO Calls for Cancer Trials to Include More Seniors

TUESDAY, July 28, 2015 (HealthDay News) -- In a position statement published online July 20 in the Journal of Clinical Oncology, the American Society of Clinical Oncology has called on the U.S. government and the cancer research community to broaden clinical trials to include older adults.

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Not Resecting Ideal Candidates Ups Mortality in Liver Cancer

TUESDAY, July 28, 2015 (HealthDay News) -- For patients with hepatocellular carcinoma (HCC), not resecting ideal candidates for resection is associated with increased mortality, according to a study published in the Aug. 1 issue of Hepatology.

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Delays Noted in the Reporting of Serious Patient Harms to FDA

MONDAY, July 27, 2015 (HealthDay News) -- About 10 percent of cases where a drug does serious harm are not reported to the U.S. Food and Drug Administration within the required 15-day period, according to a new analysis published online July 27 as a research letter in JAMA Internal Medicine.

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Cancer Patients Lack Awareness of Fertility Preservation Options

MONDAY, July 27, 2015 (HealthDay News) -- Many young cancer patients -- especially females -- have limited awareness about options to preserve their fertility, according to a study published online July 27 in Cancer.

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35% of Colorectal Cancers in Patients Age ≤35 Are Genetic

MONDAY, July 27, 2015 (HealthDay News) -- More than a third of colorectal cancers diagnosed in younger patients are caused by inherited gene mutations, according to a study published online July 20 in the Journal of Clinical Oncology.

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FDA Approves Odomzo for Recurring Basal Cell Carcinoma

FRIDAY, July 24, 2015 (HealthDay News) -- Odomzo (sonidegib) has been approved by the U.S. Food and Drug Administration to treat patients with locally advanced basal cell carcinoma that has returned despite surgery or radiation, or who are not candidates for additional surgery or radiation.

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Generic Meds Boost Survival in Some Early Breast Cancers

FRIDAY, July 24, 2015 (HealthDay News) -- There's more evidence that two classes of generic drugs (aromatase inhibitors and bisphosphonates) reduce the risk of death in postmenopausal women with early breast cancer, according to two studies published online July 23 in The Lancet.

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Chemotherapy Use Doesn't Improve QOL Near Death

FRIDAY, July 24, 2015 (HealthDay News) -- For patients with end-stage cancer, chemotherapy use does not improve quality of life near death (QOD), even for those with good performance status, according to a study published online July 23 in JAMA Oncology.

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Oncologists Offer Strategies for Reducing Cost of Cancer Drugs

FRIDAY, July 24, 2015 (HealthDay News) -- Soaring costs for cancer drugs are detrimental to patient care in the United States, say a group of oncologists. Recommendations on how to address the problem are presented in a commentary piece published online July 23 in the Mayo Clinic Proceedings.

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Review: Eradicating H. pylori Cuts Incidence of Gastric Cancer

FRIDAY, July 24, 2015 (HealthDay News) -- Eradication of Helicobacter pylori in asymptomatic adults is associated with a reduction in the incidence of gastric cancer, according to a review published online July 22 in The Cochrane Library.

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Expansion of High-Deductible Plans to Impact Physician Care

FRIDAY, July 24, 2015 (HealthDay News) -- As a result of the increasing popularity of high-deductible health care plans, patients now have more financial responsibility for medical services, which is impacting physician practices, according to an article published in Medical Economics.

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Evidence of Cellular Damage From Computed Tomography

THURSDAY, July 23, 2015 (HealthDay News) -- Cellular damage occurs when people undergo computed tomography (CT) scans, but whether or not this causes cancer or any other health problems is unclear, according to a study published online July 22 in the JACC: Cardiovascular Imaging.

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Nodal Radiation Doesn't Impact Early Breast Cancer Survival

THURSDAY, July 23, 2015 (HealthDay News) -- Some women who have surgery for early-stage breast cancer may benefit from additional radiation to nearby lymph nodes, although there is no clear advantage in overall survival, two new clinical trials suggest. The studies were published in the July 23 issue of the New England Journal of Medicine.

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Pharmacological Prophylaxis Doesn't Cut VTE in Cirrhosis

THURSDAY, July 23, 2015 (HealthDay News) -- Pharmacological thromboprophylaxis does not reduce the risk of venous thromboembolism (VTE) in patients with cirrhosis, according to a study published in the July issue of the Journal of Thrombosis and Haemostasis.

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No Link Found Between Testosterone Therapy and VTE

WEDNESDAY, July 22, 2015 (HealthDay News) -- Testosterone therapy doesn't appear to increase the risk of venous thromboembolism (VTE), according to a study published online July 20 in the Mayo Clinic Proceedings.

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Pioglitazone Not Significantly Associated With Bladder Cancer

TUESDAY, July 21, 2015 (HealthDay News) -- Despite smaller, prior studies suggesting that pioglitazone might raise users' risk of bladder cancer, a large new study finds no statistically significant association. The research was published in the July 21 issue of the Journal of the American Medical Association.

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Targeted Prophylaxis Effective in Post-Prostate Biopsy Sepsis

TUESDAY, July 21, 2015 (HealthDay News) -- For patients undergoing transrectal prostate biopsy, targeted prophylaxis is similarly effective to empirical prophylaxis for prevention of post-biopsy sepsis, according to a study published in the August issue of The Journal of Urology.

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CMS Finalizes Decision to Cover HPV Testing for Cervical Cancer

TUESDAY, July 21, 2015 (HealthDay News) -- The Centers for Medicare & Medicaid Services (CMS) has finalized the decision to cover human papillomavirus (HPV) testing once every five years in conjunction with a Pap smear test for asymptomatic Medicare beneficiaries aged 30 to 65 years, according to a report published by the American Academy of Family Physicians (AAFP).

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Computerized System Almost Completely Cuts Medical Errors

TUESDAY, July 21, 2015 (HealthDay News) -- Over five years, a computerized physician order entry (CPOE) system can reduce medical errors (MEs), with no new type of errors detected, according to a study published online July 14 in the Journal of Clinical Pharmacy and Therapeutics.

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ASCO Guidelines: Biomarker Use in Metastatic Breast CA Treatment

TUESDAY, July 21, 2015 (HealthDay News) -- Biomarkers can be used to guide decisions on systemic therapy for women with metastatic breast cancer, according to the American Society of Clinical Oncology Clinical Practice Guideline published online July 20 in the Journal of Clinical Oncology.

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Patients Not Talking About Using Alternative Therapies for Pain

MONDAY, July 20, 2015 (HealthDay News) -- Many Americans with chronic pain who use alternative therapies -- such as acupuncture -- don't discuss these treatments with their doctors, new research finds. The study was published online July 20 in the American Journal of Managed Care.

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Article Answers Reader Questions About Coding

MONDAY, July 20, 2015 (HealthDay News) -- Reader questions about coding a new evaluation and management (E/M) with modifier 25 and codes for three-dimensional (3D) mammograms are answered in an article published in Medical Economics.

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Prostate Cancer Interacts With Comorbidity to Increase VTE Rate

MONDAY, July 20, 2015 (HealthDay News) -- For men with prostate cancer (PC), the rate of venous thromboembolism (VTE) is increased with high comorbidity, according to a study published online July 6 in Cancer.

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More Radiation Doesn't Up Survival in Low-Risk Prostate CA

FRIDAY, July 17, 2015 (HealthDay News) -- Higher doses of radiation may improve survival in men with intermediate- and high-risk prostate cancers, but it does not do the same for those with low-risk disease, according to a study published online July 16 in JAMA Oncology.

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Clinicians May Harbor Biases About Sexual Orientation

FRIDAY, July 17, 2015 (HealthDay News) -- Clinicians may be biased when it comes to the sexual orientation of patients, new research suggests. The study was published online July 16 in the American Journal of Public Health.

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CMS May Adopt Doctors' Calls for End-of-Life Counseling

FRIDAY, July 17, 2015 (HealthDay News) -- A proposed rule from the Centers for Medicare & Medicaid Services (CMS) would implement physicians' calls to pay for end-of-life counseling, according to a report published by the American Medical Association (AMA).

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Increasing Aerobic Exercise Rx Benefits Older Women

FRIDAY, July 17, 2015 (HealthDay News) -- Doubling the recommended weekly exercise amount may help postmenopausal women lose significantly more body fat, according to research findings reported online July 16 in JAMA Oncology.

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Many Low-Risk Prostate Cancer Cases Upgraded at Prostatectomy

FRIDAY, July 17, 2015 (HealthDay News) -- Many clinically low-risk prostate cancer patients are upgraded at prostatectomy, according to a study published in the August issue of The Journal of Urology.

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AMA Suggests Ways to Encourage Use of Patient Portals

THURSDAY, July 16, 2015 (HealthDay News) -- Measures can be taken to encourage patients to use patient portals to help ensure practices meet current Stage 2 meaningful use requirements, according to an article published by the American Medical Association (AMA).

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Trend Alert: Sunburn 'Art' Growing Presence on Social Media

THURSDAY, July 16, 2015 (HealthDay News) -- Experts are speaking out against "sunburn art," a new social media trend in which people use stencils or strategically applied sunblock to create a do-it-yourself temporary sunburn tattoo on their bodies.

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Genes May Be Key to a Better HIV Vaccine

THURSDAY, July 16, 2015 (HealthDay News) -- An individual's genetic makeup may determine whether an HIV vaccine will work, a new study suggests. The findings were published in the July 15 issue of Science Translational Medicine.

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Antibodies to Serum Amyloid P Deplete Amyloid Deposits

THURSDAY, July 16, 2015 (HealthDay News) -- For patients with systemic amyloidosis, treatment with (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC) followed by an anti-serum amyloid P component (SAP) efficiently depletes amyloid load in the liver and kidney, according to a study published online July 15 in the New England Journal of Medicine.

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Choosing Wisely: How to Implement in Clinical Practice

THURSDAY, July 16, 2015 (HealthDay News) -- Strategies should be adopted to help with implementation of the Choosing Wisely program, which was designed to address the problem of medical overuse, according to an article published in the July/August issue of Family Practice Management.

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Breast CA Survivors Gain More Weight Than Cancer-Free Peers

WEDNESDAY, July 15, 2015 (HealthDay News) -- Among women with a family history of breast cancer, breast cancer survivors tend to gain more weight than women who are free of the disease, new research suggests. The study was published online July 15 in Cancer Epidemiology, Biomarkers & Prevention.

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Few U.S. States Mandate Human Papillomavirus Vaccine

WEDNESDAY, July 15, 2015 (HealthDay News) -- Almost a decade after the human papillomavirus (HPV) vaccine was first recommended for girls, only two U.S. states and Washington, D.C., require the immunization, according to a research letter published in the July 14 issue of the Journal of the American Medical Association.

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Leisure Time Sitting Linked to Increased Risk of Specific Cancers

WEDNESDAY, July 15, 2015 (HealthDay News) -- High levels of time spent sitting may increase a woman's odds for cancer, particularly multiple myeloma, breast, and ovarian cancers, according to a study published online June 30 in Cancer Epidemiology, Biomarkers & Prevention.

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High Doses of Antibiotic Ups Risk of Over-Anticoagulation

WEDNESDAY, July 15, 2015 (HealthDay News) -- Among hospitalized patients, high-dose amoxicillin/clavulanate correlates with increased risk of over-anticoagulation when combined with warfarin, according to a study published online July 2 in the Journal of Clinical Pharmacology.

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Prenatal Genetic Tests Can Identify Maternal Cancers

TUESDAY, July 14, 2015 (HealthDay News) -- Abnormal results on noninvasive prenatal genetic tests may indicate maternal cancers rather than a medical issue with the fetus, according to research published online July 13 in the Journal of the American Medical Association.

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Progress in Reporting Conflict of Interest Among IRB Members

TUESDAY, July 14, 2015 (HealthDay News) -- Among institutional review board (IRB) members, there has been positive progress in the reporting and management of conflicts of interest, according to a study published online July 13 in JAMA Internal Medicine.

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Arts Observation Curriculum May Be Beneficial for Medical Students

TUESDAY, July 14, 2015 (HealthDay News) -- Use of an arts observation curriculum can help students learn to observe objectively and articulate their observations, which are important traits for clinical practice, according to an article published online July 3 in Academic Medicine.

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ASCO Updates Guidelines for Colony-Stimulating Factor Use

TUESDAY, July 14, 2015 (HealthDay News) -- The 2006 American Society of Clinical Oncology guidelines on use of hematopoietic colony-stimulating factors (CSFs) have been updated, according to a special article published online July 13 in the Journal of Clinical Oncology.

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FDA Approves Iressa for EGFR+ Metastatic Lung Cancer

MONDAY, July 13, 2015 (HealthDay News) -- Iressa (gefitinib) has been approved by the U.S. Food and Drug Administration to treat patients with metastatic non-small-cell lung cancer (NSCLC) with a specific genetic mutation (epidermal growth factor receptor [EGFR]). A just-approved companion diagnostic test can identify patients who could benefit from this new use.

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CDC: Most Americans in Favor of Raising Legal Smoking Age to 21

THURSDAY, July 9, 2015 (HealthDay News) -- Three-quarters of American adults favor raising the legal smoking age to 21, according to a report published online July 6 in the American Journal of Preventive Medicine.

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Pockets of U.S. Have Excessive Colorectal Cancer Mortality

WEDNESDAY, July 8, 2015 (HealthDay News) -- People living in 94 counties spread across the lower Mississippi Delta region, in 107 counties in west-central Appalachia, and in 37 counties in eastern Virginia/North Carolina have seen little change in lives lost to colorectal cancer, according to a study published online July 8 in Cancer Epidemiology, Biomarkers & Prevention.

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Benefits of Extended Anticoagulation May Not Last

WEDNESDAY, July 8, 2015 (HealthDay News) -- The benefit of extended anticoagulation after pulmonary embolism dissipates after cessation of active therapy, according to a study published in the July 7 issue of the Journal of the American Medical Association.

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ASCO Endorses ASTRO Guidelines for Endometrial Cancer

WEDNESDAY, July 8, 2015 (HealthDay News) -- The American Society of Clinical Oncology (ASCO) has endorsed postoperative radiation therapy guidelines for endometrial cancer, according to a report published online July 6 in the Journal of Clinical Oncology.

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Non-AIDS In-Hospital Deaths Up in HIV-Infected Patients

WEDNESDAY, July 8, 2015 (HealthDay News) -- Trends in hospital deaths among HIV-infected patients show that mortality during the antiretroviral therapy (ART) era is often caused by diseases and conditions other than AIDS. The findings were published online June 30 in the Journal of Hospital Medicine.

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Surveillance Becoming More Common for Prostate Cancer

TUESDAY, July 7, 2015 (HealthDay News) -- More U.S. physicians are sparing their low-risk prostate cancer patients from prostatectomy, radiation, and androgen deprivation monotherapy in favor of active surveillance/watchful waiting, according to a research letter published in the July 7 issue of the Journal of the American Medical Association.

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Court Upholds Medical Liability Damages Cap

TUESDAY, July 7, 2015 (HealthDay News) -- The non-economic damages cap under the Medical Injury Compensation Reform Act (MICRA) has been upheld again in a California court of appeal, according to a report published by the American Medical Association.

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Despite Risk to Patients, Health Providers Often Work While Sick

MONDAY, July 6, 2015 (HealthDay News) -- Many health care professionals work when they are sick, putting their patients at risk for serious illness or even death, according to a study published online July 6 in JAMA Pediatrics.

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Regular Mammograms May Lead to Widespread Overdiagnosis

MONDAY, July 6, 2015 (HealthDay News) -- Increased numbers of small cancers and precancerous lesions are found in geographical areas where more mammograms take place; however, the higher screening rates are not associated with reduced breast cancer mortality, according to a study published online July 6 in JAMA Internal Medicine.

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Mortality Rates Declining for Many Cancers

MONDAY, July 6, 2015 (HealthDay News) -- For many cancers, mortality rates are declining and are expected to meet Healthy People 2020 (HP2020) targets, according to a study published online July 2 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Split-Dose Better Than Day-Before Colonoscopy Prep

MONDAY, July 6, 2015 (HealthDay News) -- Split-dose regimens increase the quality of colon cleansing compared to day-before colonoscopy preparation, according to a review and meta-analysis published in the July issue of Gastroenterology.

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Genetic Mutations May Impact Outcomes in Aplastic Anemia

MONDAY, July 6, 2015 (HealthDay News) -- Certain genetic mutations may be correlated with response to therapy and prognosis in aplastic anemia, according to research published in the July 2 issue of the New England Journal of Medicine.

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Worse Survival With Chemo Dose Reduction in Ovarian Cancer

THURSDAY, July 2, 2015 (HealthDay News) -- Chemotherapy dose reduction is associated with worse survival in ovarian cancer, according to a study published online July 2 in JAMA Oncology.

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Asian-Language Smoking Quitline Successful Nationwide

THURSDAY, July 2, 2015 (HealthDay News) -- An Asian-Language Smokers Quitline (ASQ) reaches Chinese, Korean, and Vietnamese speakers nationwide, and most callers receive medication and counseling, according to a study published online June 25 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Weight Loss + Vitamin D3 Cuts IL-6 in Postmenopausal Women

THURSDAY, July 2, 2015 (HealthDay News) -- Weight loss of 5 percent or more, combined with vitamin D3 supplementation, is associated with significant reductions in interleukin-6 in postmenopausal women, according to a study published recently in Cancer Prevention Research.

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Residents' Knowledge of High-Value Care Varies

WEDNESDAY, July 1, 2015 (HealthDay News) -- U.S. internal medicine (IM) residents report varying knowledge and practice of high-value care (HVC), according to research published online June 16 in Academic Medicine.

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Public Opinion Sought on New Licensure for Assistant Physicians

WEDNESDAY, July 1, 2015 (HealthDay News) -- New classification of licensure for assistant physicians has been created, and public opinion is being sought by the Missouri State Board of Registration for the Healing Arts prior to filing these rules with the Secretary of State's Office and the Joint Committee on Administrative Rules.

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