July 2015 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for July 2015. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Treatment Targets Not Met by Most Older Patients With Diabetes

FRIDAY, July 31, 2015 (HealthDay News) -- Only one-third of American seniors with diabetes have their disease under control as defined by the American Diabetes Association (ADA) guidelines, according to research published in the July issue of the Diabetes Care.

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Targeted Exercises Can Boost Men's Bone Health

FRIDAY, July 31, 2015 (HealthDay News) -- Resistance and "jump" training can improve bone health in moderately active middle-aged men with osteopenia, according to a small new study. The findings were published online July 16 in Bone.

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AMA Wants Doctor Input on EHRs, Meaningful Use

FRIDAY, July 31, 2015 (HealthDay News) -- The American Medical Association (AMA) is encouraging clinicians to share their perspectives on electronic heath records (EHRs) and the meaningful use program.

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U.S. Health Spending Projected to Rise 5.8 Percent By 2024

FRIDAY, July 31, 2015 (HealthDay News) -- From 2014 to 2024, U.S. health spending growth is projected to increase by about 6 percent, according to a report published online July 28 in Health Affairs.

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'Thrifty Phenotype' Leads to Less Weight Loss in Obese

FRIDAY, July 31, 2015 (HealthDay News) -- For obese individuals, energy expenditure during fasting and response to overfeeding predict weight loss in response to caloric restriction, according to a study published in the August issue of Diabetes.

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New Drug Effectively Lowers Levels of Triglycerides

THURSDAY, July 30, 2015 (HealthDay News) -- An experimental drug, ISIS 304801, can lower triglyceride levels by as much as 71 percent, according to study results published in the July 30 issue of the New England Journal of Medicine.

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Hippocampal Insulin Resistance Linked to Neuroplasticity

THURSDAY, July 30, 2015 (HealthDay News) -- Hippocampal insulin resistance may be a key mediator of cognitive deficits, independent of glycemic control, according to an experimental study published online July 27 in Diabetes.

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FDA Approves Balloon Device to Treat Obesity

WEDNESDAY, July 29, 2015 (HealthDay News) -- The ReShape Integrated Dual Balloon System has been approved by the U.S. Food and Drug Administration to combat adult obesity. Inflated inside the stomach, the device appears to create a sense of fullness, although how it works isn't completely understood, the FDA said in a news release.

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Low Incidence of Diabetic Ketoacidosis With Canagliflozin

WEDNESDAY, July 29, 2015 (HealthDay News) -- For canagliflozin-treated patients with type 2 diabetes, the incidence of serious adverse events of diabetic ketoacidosis (DKA) is low, according to research published online July 22 in Diabetes Care.

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RAPID Score Validated for Prognosis of Pleural Infections

WEDNESDAY, July 29, 2015 (HealthDay News) -- The recently developed RAPID score, which identifies the risk of mortality in patients with pleural infections based on five clinical factors, has been validated in a diverse patient cohort. The findings have been published online July 20 in the Annals of the American Thoracic Society.

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2015 MOC Program Expected to Cost $5.7 Billion Over 10 Years

WEDNESDAY, July 29, 2015 (HealthDay News) -- The 2015 version of the American Board of Internal Medicine (ABIM) maintenance-of-certification (MOC) program is expected to generate considerable costs, mainly due to physician time costs, according to research published online July 28 in the Annals of Internal Medicine.

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Patients Report Improved Care Access, Better Health With ACA

TUESDAY, July 28, 2015 (HealthDay News) -- Millions more Americans have affordable health insurance, access to a personal doctor, and feel they are in better health following the first two open-enrollment periods of the Affordable Care Act (ACA), a new analysis shows. The results are published in the July 28 issue of the Journal of the American Medical Association.

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Components of Mediterranean Lifestyle Cut Postprandial Lipemia

TUESDAY, July 28, 2015 (HealthDay News) -- Components of the Mediterranean lifestyle may reduce postprandial lipemia (PPL), an independent risk factor for cardiovascular disease, according to a review published online July 7 in the American Journal of Physiology: Endocrinology and Metabolism.

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Atorvastatin/Ezetimibe Beats Atorvastatin After PCI

TUESDAY, July 28, 2015 (HealthDay News) -- For Japanese patients who have undergone percutaneous coronary intervention (PCI), atorvastatin plus ezetimibe is associated with improved outcomes versus atorvastatin alone, according to a study published in the Aug. 4 issue of the Journal of the American College of Cardiology.

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Higher Health Costs for Diabetes Mainly Meds, Inpatient Care

TUESDAY, July 28, 2015 (HealthDay News) -- From 2002 to 2012, individuals with diabetes had consistently higher health expenditure compared to those without diabetes, according to a study published online July 22 in Diabetes Care.

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FDA Approves Praluent for Certain Cases of High Cholesterol

MONDAY, July 27, 2015 (HealthDay News) -- Praluent (alirocumab) injection has been approved by the U.S. Food and Drug Administration for use in addition to diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease, who need additional low-density lipoprotein (LDL) cholesterol reduction.

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Delays Noted in the Reporting of Serious Patient Harms to FDA

MONDAY, July 27, 2015 (HealthDay News) -- About 10 percent of cases where a drug does serious harm are not reported to the U.S. Food and Drug Administration within the required 15-day period, according to a new analysis published online July 27 as a research letter in JAMA Internal Medicine.

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Risk of Death Up With Lower Extremity Amputation in Diabetes

MONDAY, July 27, 2015 (HealthDay News) -- Patients with diabetes and a lower extremity amputation (LEA) are more likely to die, with some of the increased risk due to diabetes-related complications, according to a study published online July 22 in Diabetes Care.

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Cannabis Alleviates Peripheral Neuropathic Pain in Diabetes

FRIDAY, July 24, 2015 (HealthDay News) -- A small trial shows a dose-dependent reduction in peripheral neuropathic pain in patients with diabetes, according to a study published in the July issue of The Journal of Pain.

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Expansion of High-Deductible Plans to Impact Physician Care

FRIDAY, July 24, 2015 (HealthDay News) -- As a result of the increasing popularity of high-deductible health care plans, patients now have more financial responsibility for medical services, which is impacting physician practices, according to an article published in Medical Economics.

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Improved Metabolic Profile After Roux-en-Y Gastric Bypass

THURSDAY, July 23, 2015 (HealthDay News) -- Roux-en-Y gastric bypass (RYGB) is associated with attenuated markers of oxidative stress in subcutaneous adipose tissue, according to a study published recently in Diabetes.

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Two Trajectories of Childhood Growth for Type 2 Diabetes

WEDNESDAY, July 22, 2015 (HealthDay News) -- Two trajectories of growth correlate with development of type 2 diabetes, according to a study published in the August issue of the Journal of Internal Medicine.

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Blood Glucose Meter Accuracy Unclear at Low Glycemic Range

WEDNESDAY, July 22, 2015 (HealthDay News) -- The accuracy of blood glucose meters (BGMs) in the low glycemic range is questionable, according to an observation letter published online July 15 in Diabetes Care.

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Glitazone Usage Tied to Lower Risk for Parkinson's Disease

WEDNESDAY, July 22, 2015 (HealthDay News) -- Use of glitazones may help protect against Parkinson's disease, according to new research published online July 21 in PLOS Medicine.

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Psoriasis Med May Help Preserve Pancreas Function in Type 1 DM

WEDNESDAY, July 22, 2015 (HealthDay News) -- Taking two 12-week courses of alefacept -- a drug already approved to treat psoriasis -- may help people with newly diagnosed type 1 diabetes mellitus (T1DM) preserve pancreatic β-cell function, a new study suggests. The findings were published online July 20 in the Journal of Clinical Investigation.

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No Link Found Between Testosterone Therapy and VTE

WEDNESDAY, July 22, 2015 (HealthDay News) -- Testosterone therapy doesn't appear to increase the risk of venous thromboembolism (VTE), according to a study published online July 20 in the Mayo Clinic Proceedings.

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Pioglitazone Not Significantly Associated With Bladder Cancer

TUESDAY, July 21, 2015 (HealthDay News) -- Despite smaller, prior studies suggesting that pioglitazone might raise users' risk of bladder cancer, a large new study finds no statistically significant association. The research was published in the July 21 issue of the Journal of the American Medical Association.

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Extensive Nonadherence to Vaccine Guidelines in Diabetes

MONDAY, July 20, 2015 (HealthDay News) -- Among patients with diabetes, considered to be at increased risk of infection and infectious complications, there is considerable nonadherence to national guidelines for hepatitis B, influenza, and 23-valent pneumococcal polysaccharide vaccines, according to a study published in the July issue of Clinical Diabetes.

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Autoimmune Risk Up for Relatives of Those With Celiac Disease

MONDAY, July 20, 2015 (HealthDay News) -- First-degree relatives and spouses of those with celiac disease have increased risk for nonceliac autoimmune disease, according to a study published in the July issue of Clinical Gastroenterology and Hepatology.

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Most Obese Patients Never Reach a Healthy Weight

FRIDAY, July 17, 2015 (HealthDay News) -- Weight loss is considered a major health goal for people who are obese, but the reality is that few reach a normal weight or keep any lost pounds off, according to a study published online July 16 in the American Journal of Public Health.

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Clinicians May Harbor Biases About Sexual Orientation

FRIDAY, July 17, 2015 (HealthDay News) -- Clinicians may be biased when it comes to the sexual orientation of patients, new research suggests. The study was published online July 16 in the American Journal of Public Health.

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CVD Risk Similar for Metformin + Insulin or Sulfonylureas

FRIDAY, July 17, 2015 (HealthDay News) -- For patients with type 2 diabetes, the risk of myocardial infarction (MI) or stroke is similar for treatment with insulin or sulfonylureas in combination with metformin, according to a study published online July 14 in Diabetes, Obesity and Metabolism.

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Increasing Aerobic Exercise Rx Benefits Older Women

FRIDAY, July 17, 2015 (HealthDay News) -- Doubling the recommended weekly exercise amount may help postmenopausal women lose significantly more body fat, according to research findings reported online July 16 in JAMA Oncology.

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CDC: ACA May Have Boosted Uptake of Preventive Care

FRIDAY, July 17, 2015 (HealthDay News) -- Americans are up to three times more likely to receive preventive care if they have health insurance, federal officials reported Thursday. And people paying for private insurance received the same preventive care as people on Medicaid or Medicare, according to the findings published in the July 17 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Weight Disqualifies 1 in 3 Young Adults From U.S. Military

THURSDAY, July 16, 2015 (HealthDay News) -- One-third of young adults in the United States are too overweight to be in the military, according to a report from a group of retired military leaders.

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AMA Suggests Ways to Encourage Use of Patient Portals

THURSDAY, July 16, 2015 (HealthDay News) -- Measures can be taken to encourage patients to use patient portals to help ensure practices meet current Stage 2 meaningful use requirements, according to an article published by the American Medical Association (AMA).

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Choosing Wisely: How to Implement in Clinical Practice

THURSDAY, July 16, 2015 (HealthDay News) -- Strategies should be adopted to help with implementation of the Choosing Wisely program, which was designed to address the problem of medical overuse, according to an article published in the July/August issue of Family Practice Management.

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Early Healthy Eating Intervention in Pregnancy Helps Obese Women

THURSDAY, July 16, 2015 (HealthDay News) -- A healthy eating (HE) intervention is associated with lower gestational weight gain (GWG) and fasting glucose than a physical activity (PA) intervention, according to a study published online June 25 in Diabetes Care.

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Patiromer Treats Hyperkalemia in Diabetic Kidney Disease

WEDNESDAY, July 15, 2015 (HealthDay News) -- A new drug, patiromer, decreases serum potassium levels in patients with hyperkalemia and diabetic kidney disease, according to the results of a phase 2 study published in the July 14 issue of the Journal of the American Medical Association.

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Metoclopramide Nasal Spray Helps Gastroparesis in Women

WEDNESDAY, July 15, 2015 (HealthDay News) -- For women, but not men, with diabetes, metoclopramide nasal spray reduces symptoms of gastroparesis, according to a study published in the July issue of Clinical Gastroenterology and Hepatology.

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Progress in Reporting Conflict of Interest Among IRB Members

TUESDAY, July 14, 2015 (HealthDay News) -- Among institutional review board (IRB) members, there has been positive progress in the reporting and management of conflicts of interest, according to a study published online July 13 in JAMA Internal Medicine.

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Arts Observation Curriculum May Be Beneficial for Medical Students

TUESDAY, July 14, 2015 (HealthDay News) -- Use of an arts observation curriculum can help students learn to observe objectively and articulate their observations, which are important traits for clinical practice, according to an article published online July 3 in Academic Medicine.

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Uncontrolled Diabetes Linked to Increased Risk of Dementia

TUESDAY, July 14, 2015 (HealthDay News) -- Diabetes patients with high rates of complications from the disease may face increased risk for dementia, according to a study published online July 9 in the Journal of Clinical Endocrinology & Metabolism.

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Metformin in Pregnancy Shows No Effect on Infant Birth Weight

MONDAY, July 13, 2015 (HealthDay News) -- Use of metformin during pregnancy doesn't impact the birth weight of infants born to obese mothers, according to a study published online July 9 in The Lancet Diabetes & Endocrinology.

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Strategies Needed to Combat Weight Gain in Smoking Cessation

MONDAY, July 13, 2015 (HealthDay News) -- Quitting smoking is associated with weight gain, according to a meta-analysis published online June 26 in Obesity Reviews, and clinicians are encouraged to help patients who are undergoing cessation achieve/maintain a healthy weight.

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Lifestyle Intervention Can Ward Off Obesity-Related Knee Pain

MONDAY, July 13, 2015 (HealthDay News) -- For overweight adults with diabetes mellitus, an intensive lifestyle intervention (ILI) can prevent knee pain, according to a study published in the July issue of Arthritis Care & Research.

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Many Overweight Teens Don't See Their Weight As a Problem

FRIDAY, July 10, 2015 (HealthDay News) -- Many overweight and obese teens don't believe they have a weight problem, according to a study published online July 9 in the International Journal of Obesity.

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FDA Strengthens Heart Attack, Stroke Warning for NSAIDs

FRIDAY, July 10, 2015 (HealthDay News) -- The U.S Food and Drug Administration on Thursday strengthened the warning labels for non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), regarding increased risk of heart attack or stroke.

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CDC: Too Few Americans Eating Enough Fruits, Vegetables

FRIDAY, July 10, 2015 (HealthDay News) -- Most Americans are not consuming the recommended amount of fruits and vegetables, according to a new report published in the July 10 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Testosterone Tx Offers Little Help for Ejaculatory Dysfunction

FRIDAY, July 10, 2015 (HealthDay News) -- Testosterone supplements don't improve ejaculatory function in men with low testosterone, according to research published online July 9 in the Journal of Clinical Endocrinology & Metabolism.

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Vitamin D Shows No Impact on Interferon Response in SLE

FRIDAY, July 10, 2015 (HealthDay News) -- For patients with systemic lupus erythematosus (SLE), vitamin D3 supplementation does not affect interferon (IFN) signature, according to a study published in the July issue of Arthritis & Rheumatology.

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T2DM Linked to Declines in Cerebral Vasoreactivity, Cognition

THURSDAY, July 9, 2015 (HealthDay News) -- In as little as two years, patients with type 2 diabetes may exhibit diminished global and regional cerebral vasoreactivity, which could negatively affect cognitive skills, a small study suggests. The findings were published online July 8 in Neurology.

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Misunderstanding of Term 'Hypertension' May Impact Care

WEDNESDAY, July 8, 2015 (HealthDay News) -- Misunderstanding of the term hypertension may impact antihypertensive medication use and adherence, according to a perspective piece published online July 7 in Circulation: Cardiovascular Quality and Outcomes.

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Depression Up Among Men With Borderline Testosterone

WEDNESDAY, July 8, 2015 (HealthDay News) -- Men with borderline testosterone levels frequently have depression and depressive symptoms, according to a study published online June 30 in the Journal of Sexual Medicine.

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Correction of Vitamin B-12 Deficiency No Benefit in Seniors

WEDNESDAY, July 8, 2015 (HealthDay News) -- For older adults, vitamin B-12 supplementation is not associated with improvements in neurologic or cognitive function, according to a study published online July 1 in the American Journal of Clinical Nutrition.

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Life Expectancy Substantially Drops With Disease Combo

TUESDAY, July 7, 2015 (HealthDay News) -- While having one major health problem -- such as diabetes, myocardial infarction, or stroke -- can increase the risk for an early death, new research warns that the risk of dying prematurely goes up significantly for individuals with more than one of these conditions. The findings were reported in the July 7 issue of the Journal of the American Medical Association.

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Court Upholds Medical Liability Damages Cap

TUESDAY, July 7, 2015 (HealthDay News) -- The non-economic damages cap under the Medical Injury Compensation Reform Act (MICRA) has been upheld again in a California court of appeal, according to a report published by the American Medical Association.

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Despite Risk to Patients, Health Providers Often Work While Sick

MONDAY, July 6, 2015 (HealthDay News) -- Many health care professionals work when they are sick, putting their patients at risk for serious illness or even death, according to a study published online July 6 in JAMA Pediatrics.

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Questions Raised for Telemedical Monitoring of Diabetic Foot Ulcers

MONDAY, July 6, 2015 (HealthDay News) -- Telemedicine monitoring is not associated with any significant difference in amputation or healing, but may be linked to increased mortality for patients with diabetic foot ulcers, according to a study published online June 26 in Diabetes Care.

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Adapted Diabetes Prevention Program Deemed Effective

MONDAY, July 6, 2015 (HealthDay News) -- An adapted Diabetes Prevention Program (DPP) lifestyle intervention significantly improves cardiovascular disease-related risk factors among participants, according to a study published in the June issue of the Journal of the American Geriatrics Society.

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Asian-Language Smoking Quitline Successful Nationwide

THURSDAY, July 2, 2015 (HealthDay News) -- An Asian-Language Smokers Quitline (ASQ) reaches Chinese, Korean, and Vietnamese speakers nationwide, and most callers receive medication and counseling, according to a study published online June 25 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Once-Daily 3.0 mg Liraglutide Tied to Reduction in Body Weight

THURSDAY, July 2, 2015 (HealthDay News) -- A once-daily dose of 3.0 mg liraglutide, injected subcutaneously, is associated with greater reduction in body weight than placebo, according to a study published in the July 2 issue of the New England Journal of Medicine.

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Weight Loss + Vitamin D3 Cuts IL-6 in Postmenopausal Women

THURSDAY, July 2, 2015 (HealthDay News) -- Weight loss of 5 percent or more, combined with vitamin D3 supplementation, is associated with significant reductions in interleukin-6 in postmenopausal women, according to a study published recently in Cancer Prevention Research.

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Bariatric Surgery Beats Lifestyle Change for T2DM Remission

WEDNESDAY, July 1, 2015 (HealthDay News) -- Three-year outcomes indicate that bariatric surgery is superior to lifestyle intervention alone for inducing remission of type 2 diabetes mellitus (T2DM) in obese patients, according to research published online July 1 in JAMA Surgery.

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Obese Teen Girls Less Likely to Use Contraception

WEDNESDAY, July 1, 2015 (HealthDay News) -- Obesity is associated with less frequent and less consistent contraceptive use among sexually active 18- to 19-year-old girls, according to research published online July 1 in The Journal of Pediatrics.

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Residents' Knowledge of High-Value Care Varies

WEDNESDAY, July 1, 2015 (HealthDay News) -- U.S. internal medicine (IM) residents report varying knowledge and practice of high-value care (HVC), according to research published online June 16 in Academic Medicine.

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Public Opinion Sought on New Licensure for Assistant Physicians

WEDNESDAY, July 1, 2015 (HealthDay News) -- New classification of licensure for assistant physicians has been created, and public opinion is being sought by the Missouri State Board of Registration for the Healing Arts prior to filing these rules with the Secretary of State's Office and the Joint Committee on Administrative Rules.

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