January 2017 Briefing - Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for January 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Smoking Imposes Heavy Burden on Global Economy

TUESDAY, Jan. 31, 2017 (HealthDay News) -- Nearly 6 percent of the world's health care spending is tied to smoking, according to research published online Jan. 30 in Tobacco Control.

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Many VHA Patients Eligible for Lung Cancer Screening

TUESDAY, Jan. 31, 2017 (HealthDay News) -- Many Veterans Health Administration (VHA) patients are eligible for lung cancer screening (LCS) with low-dose computed tomography (CT), and the use of LCS is increasing slowly among eligible patients, according to two studies published online Jan. 30 in JAMA Internal Medicine.

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Quenched Activity-Based Probe Imaging Beneficial in NMSC

MONDAY, Jan. 30, 2017 (HealthDay News) -- Quenched activity-based probe imaging can discriminate cancer from normal appearing skin tissue, according to a study published in the February issue of the Journal of the American Academy of Dermatology.

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Pre-Transplant Depression May Impair Post-HCT Outcomes

MONDAY, Jan. 30, 2017 (HealthDay News) -- For adult patients undergoing hematopoietic cell transplantation (HCT), pre-transplant depression is associated with worse post-transplantation outcomes, according to a study published online Jan. 19 in Cancer.

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HT to Preserve Fertility Doesn't Appreciably Affect Survival

FRIDAY, Jan. 27, 2017 (HealthDay News) -- For young patients with endometrial cancer, survival does not appear to be significantly impacted by hormone therapy (HT) before surgery to preserve fertility, according to a study published online Dec. 27 in Cancer.

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Anxiety, Depression May Up Mortality Risk for Some Cancers

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Anxiety and depression may increase the risk of death from certain cancers, according to research published online Jan. 25 in The BMJ.

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28% of Adults, 9% of Teens Use Tobacco Products in U.S.

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Despite the dangers, many American adults and teens still use tobacco products, according to a report published in the Jan. 26 issue of the New England Journal of Medicine.

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Most PCPs Oppose Complete Repeal of the Affordable Care Act

THURSDAY, Jan. 26, 2017 (HealthDay News) -- A majority of primary care doctors oppose full repeal of the Affordable Care Act, according to a perspective piece published online Jan. 25 in the New England Journal of Medicine.

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Universal CAR T-Cell Therapy Helped Treat ALL in Two Infants

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Two infants with B-cell acute lymphoblastic leukemia (ALL) are in remission after treatment with genetically modified immune system cells, according to a report on the two cases published in the Jan. 25 issue of Science Translational Medicine.

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Study Assesses Sublingual Fentanyl Vs Morphine for CA Pain

THURSDAY, Jan. 26, 2017 (HealthDay News) -- For patients with severe cancer pain episodes, fentanyl sublingual tablets (FST) offer analgesia with modest to moderate increased risk of lower efficacy compared with subcutaneous morphine (SCM), according to a study published online Jan. 23 in the Journal of Clinical Oncology.

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Strategies Presented for Addressing Uncompensated Time

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Strategies can be employed to help physicians deal with the increasing burden of uncompensated tasks, according to an article published in Medical Economics.

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Chemo May Be Overused in Younger Patients With Colon CA

WEDNESDAY, Jan. 25, 2017 (HealthDay News) -- Young and middle-aged colon cancer patients may be getting chemotherapy more often than is warranted, according to a study published online Jan. 25 in JAMA Surgery.

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Overall Cancer Mortality Rate Down in the United States

WEDNESDAY, Jan. 25, 2017 (HealthDay News) -- While cancer mortality rates have dropped 20 percent overall in the United States since 1980, high mortality rates persist in pockets throughout the country, according to a report published in the Jan. 24/31 issue of the Journal of the American Medical Association.

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Meta-Analysis: Caprini Score IDs Benefit of VTE Prophylaxis

WEDNESDAY, Jan. 25, 2017 (HealthDay News) -- Perioperative venous thromboembolism (VTE) prophylaxis is beneficial only for surgical patients with Caprini scores of ≥7, according to a meta-analysis published online Jan. 23 in the Annals of Surgery.

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Severe Side Effects Common Among Breast Cancer Patients

TUESDAY, Jan. 24, 2017 (HealthDay News) -- About half of early-stage breast cancer patients experience severe side effects from their treatment, according to a study published online Jan. 24 in Cancer.

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ACA Has Increased Coverage, Access for Chronically Ill Patients

TUESDAY, Jan. 24, 2017 (HealthDay News) -- Millions of Americans with a chronic illness gained health insurance coverage after the Affordable Care Act went into effect in 2010, according to a study published online Jan. 24 in the Annals of Internal Medicine.

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Superior Survival for Asian Men With Prostate Cancer

TUESDAY, Jan. 24, 2017 (HealthDay News) -- For men with distant, de novo, metastatic prostate cancer (PCa), Asian ethnicity is associated with superior median overall survival (OS) and PCa-specific mortality (PCSM), according to a study published online Jan. 5 in Cancer.

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Cervical Cancer Mortality Higher Among Older, Black Women

MONDAY, Jan. 23, 2017 (HealthDay News) -- The number of women who die from cervical cancer in the United States may be higher than previously believed, and the risk is greatest among older and black women, according to a study published online Jan. 23 in Cancer.

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Many Advanced NSCLC Patients Not Getting Helpful Treatment

MONDAY, Jan. 23, 2017 (HealthDay News) -- Many U.S. patients with late-stage non-small-cell lung cancer (NSCLC) do not receive treatments that could prolong their lives, according to a study published online Jan. 18 in the Journal of Thoracic Oncology.

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Multi-Parametric MRI Shows Benefit As Triage Test

MONDAY, Jan. 23, 2017 (HealthDay News) -- For men with high serum prostate-specific antigen, multi-parametric magnetic resonance imaging (MP-MRI) is more sensitive but less specific than transrectal ultrasound guided prostate biopsy (TRUS-biopsy) for detecting clinically significant cancer, and can be used as a triage test to avoid unnecessary biopsy, according to a study published online Jan. 19 in The Lancet.

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Nadir Platelet Counts Tied to AKI in Pediatric Open-Heart Surgery

MONDAY, Jan. 23, 2017 (HealthDay News) -- For pediatric patients undergoing cardiopulmonary bypass (CPB), postoperative nadir platelet counts are associated with the severity of acute kidney injury (AKI), according to a review published online Jan. 18 in Pediatric Anesthesia.

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Intervention Reduces Fear of Recurrence in Breast CA Survivors

MONDAY, Jan. 23, 2017 (HealthDay News) -- For breast cancer survivors, the Attention and Interpretation Modification for Fear of Breast Cancer Recurrence (AIM-FBCR) intervention shows promise for reducing fear of cancer recurrence (FCR), according to a study published online Jan. 5 in Cancer.

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Androgen Suppression Tx May Prevent Intravesical Recurrence

FRIDAY, Jan. 20, 2017 (HealthDay News) -- For men with bladder cancer, androgen suppression therapy may be prophylactic for intravesical recurrence, according to a study published in the February issue of The Journal of Urology.

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Obesity Underrepresented in Medical Licensing Exams

FRIDAY, Jan. 20, 2017 (HealthDay News) -- The most important concepts of obesity prevention and treatment are not adequately represented on the U.S. Medical Licensing Examination (USMLE) Step examinations, according to a study published recently in Teaching and Learning in Medicine.

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High SPF Sunscreen Offers Better Protection Than Beach Umbrella

FRIDAY, Jan. 20, 2017 (HealthDay News) -- Sunscreen with a high sun protection factor offers better protection than a standard beach umbrella, although neither completely prevents sunburn, according to a study published online Jan. 19 in JAMA Dermatology.

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Overall Survival Poor in Unresected Anaplastic Thyroid CA

FRIDAY, Jan. 20, 2017 (HealthDay News) -- For patients with unresected anaplastic thyroid carcinoma (ATC), overall survival (OS) is poor, but radiation therapy (RT) dose is associated with improved survival, according to a study published online Dec. 27 in Cancer.

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Genital HPV Prevalence Rate High Among Men in the United States

THURSDAY, Jan. 19, 2017 (HealthDay News) -- Nearly half of American men may be infected with human papillomavirus (HPV), and HPV vaccination coverage is low among vaccine-eligible men, according to a study published online Jan. 19 in JAMA Oncology.

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Grilled, Smoked Meats May Up Mortality Risk After Breast Cancer

THURSDAY, Jan. 19, 2017 (HealthDay News) -- Research has suggested that diets high in barbecued, grilled, and smoked meats could increase the risk of breast cancer. Now, a new study finds these cooking methods may also lower survival after a breast cancer diagnosis. The findings have been published online Jan. 4 in the Journal of the National Cancer Institute.

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Increasing Severity of Airflow Limitation Linked to Lung CA Risk

THURSDAY, Jan. 19, 2017 (HealthDay News) -- For older heavy cigarette smokers, the severity of airflow limitation is associated with increasing lung cancer risk, according to a study published online Jan. 11 in the Annals of the American Thoracic Society.

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CpG Island Methylator Phenotype Prognostic After CRC Surgery

THURSDAY, Jan. 19, 2017 (HealthDay News) -- For patients undergoing colorectal cancer (CRC) surgery, CpG island methylator phenotype (CIMP) status predicts survival, according to research published online Jan. 14 in the Journal of Gastroenterology and Hepatology.

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Recommendations Developed for Small Renal Mass Management

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- In a clinical practice guideline published online Jan. 16 in the Journal of Clinical Oncology, recommendations are presented for the management of patients with small renal masses (SRMs).

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Autologous Urethral Sling No Benefit After Prostatectomy

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- Placement of a retropubic urethral sling fashioned from autologous vas deferens during robotic assisted radical prostatectomy does not improve recovery of continence, according to a study published in the February issue of The Journal of Urology.

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Delayed Clamping Reduces Anemia at 8, 12 Months of Age

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- For infants at high risk of iron deficiency anemia, delayed umbilical cord clamping reduces anemia at 8 and 12 months of age, according to a study published online Jan. 17 in JAMA Pediatrics.

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Physician Excess Charges Create Financial Burden for Patients

TUESDAY, Jan. 17, 2017 (HealthDay News) -- Many doctors bill their private-paying patients two, three, even six times more than what Medicare pays for the same services, according to a research letter published in the Jan. 17 issue of the Journal of the American Medical Association.

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Unique Molecular Features for Vulvar, Vaginal Melanomas

TUESDAY, Jan. 17, 2017 (HealthDay News) -- Vulvar and vaginal melanomas (VVMs) have unique molecular features as compared to nongynecologic melanoma (NGM), according to a study published online Dec. 27 in Cancer.

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Video Intervention Persuasive for Screening Recommendations

MONDAY, Jan. 16, 2017 (HealthDay News) -- A novel video intervention can alter the screening intentions of a target audience, in line with evidence-based recommendations, according to a study published in the January/February issue of the Annals of Family Medicine.

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Addition of Cetuximab to CRT Cuts Locoregional Failure in Anal CA

MONDAY, Jan. 16, 2017 (HealthDay News) -- Addition of cetuximab to chemoradiation (CRT) is associated with a reduction in locoregional failure (LRF) rates in squamous cell carcinoma of the anal canal (SCCAC), according to a study published online Jan. 9 in the Journal of Clinical Oncology.

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Tobacco Counseling for Youth, Adults Cuts Smoking Prevalence

FRIDAY, Jan. 13, 2017 (HealthDay News) -- Tobacco counseling for youth or adults can reduce the prevalence of smoking cigarettes during adult years, according to a study published in the January/February issue of the Annals of Family Medicine.

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CDC: Higher Risk of Death From Leading Causes in Rural America

THURSDAY, Jan. 12, 2017 (HealthDay News) -- Americans who live in rural areas have a higher risk of death from five leading causes than people who live in urban locations, according to research published in the Jan. 13 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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New Comprehensive Report Looks at Benefits, Harms of Cannabis

THURSDAY, Jan. 12, 2017 (HealthDay News) -- Current medical science has proven there are legitimate medical uses for marijuana and cannabis-derived drugs, according to a new report -- The Health Effects of Cannabis and Cannabinoids -- published Jan. 12 by the National Academy of Sciences, Engineering, and Medicine.

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177Lu-Dotatate Ups PFS in Midgut Neuroendocrine Tumors

THURSDAY, Jan. 12, 2017 (HealthDay News) -- For patients with advanced midgut neuroendocrine tumors, lutetium-177 (177Lu)-Dotatate is associated with longer progression-free survival than high-dose octreotide long-acting repeatable (LAR), according to a study published in the Jan. 12 issue of the New England Journal of Medicine.

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Worsening QoL Linked to Early Tx Discontinuation in Breast Cancer

THURSDAY, Jan. 12, 2017 (HealthDay News) -- For women with breast cancer, experiencing a worsening in menopause-specific quality of life (QoL) is associated with early treatment discontinuation, according to a study published online Jan. 9 in the Journal of Clinical Oncology.

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Excessive FDA Regulation Driving High Drug Prices

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- The excessive regulatory regime at the U.S. Food and Drug Administration is an important driver of high drug prices, and should be curbed to introduce more competition and lower prices, according to a report published online Jan. 5 by the National Center for Policy Analysis.

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Tobacco Control Plays Key Role in Saving Both Lives and Dollars

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- Smoking kills about six million people a year, and costs the world more than $1 trillion a year in health care expenses and lost productivity, but billions of dollars and millions of lives could be saved through higher tobacco prices and taxes, according to a report from the World Health Organization and the U.S. National Cancer Institute.

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Yoga Intervention Feasible for Improving QoL in Pediatric Cancer

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- A pilot yoga intervention is feasible for improving pediatric cancer patients' and parents' quality of life, according to research published in the January issue of Rehabilitation Oncology.

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Complications in One-Third Undergoing Total Laryngectomy

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- About one-third of patients undergoing total laryngectomy (TL) have complications and 13.9 percent are readmitted within 30 days, according to a study published online Dec. 27 in Cancer.

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Mammography Found to Result in Substantial Overdiagnosis

TUESDAY, Jan. 10, 2017 (HealthDay News) -- Mammograms frequently detect small breast tumors that might never become life-threatening, causing women to receive treatment they likely don't need, according to a new study published online Jan. 10 in the Annals of Internal Medicine.

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Inflammatory Markers Prognostic in Primary Sinonasal Cancer

TUESDAY, Jan. 10, 2017 (HealthDay News) -- Pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can predict survival for patients with primary sinonasal cancers (SNCs), according to a study published online Dec. 29 in Head & Neck.

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Reduced Mortality Seen for 'Weekend Warriors'

MONDAY, Jan. 9, 2017 (HealthDay News) -- Weekend warriors may add almost as many years to their life span as those who work out all week long, according to research published online Jan. 9 in JAMA Internal Medicine.

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Improved Breast Cancer Screening Rates With ACA

MONDAY, Jan. 9, 2017 (HealthDay News) -- Americans with lower levels of income are less likely to get recommended cancer screenings, but legislation waiving out-of-pocket costs appears to narrow the prevention gap -- for mammograms, at least, according to a study published online Jan. 9 in Cancer.

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Perceived Breast Density May Affect Single Read Suitability

MONDAY, Jan. 9, 2017 (HealthDay News) -- Features related to mammographic breast density are key normal mammographic features that influence the difficulty for readers to classify mammograms as normal, according to a study published online Jan. 3 in the Journal of Medical Imaging and Radiation Oncology.

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Sorafenib Effect on HCC Survival Depends on Hepatitis Status

FRIDAY, Jan. 6, 2017 (HealthDay News) -- For patients with advanced unresectable hepatocellular carcinoma, the effect of sorafenib on overall survival (OS) is dependent on patients' hepatitis status, according to a meta-analysis published online Jan. 3 in the Journal of Clinical Oncology.

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Delayed Chemo After Surgery Still Beneficial in Lung Cancer

FRIDAY, Jan. 6, 2017 (HealthDay News) -- Chemotherapy that's been delayed due to slow recovery from non-small-cell lung cancer (NSCLC) surgical resection can still provide real benefit to patients, according to a study published online Jan. 5 in JAMA Oncology.

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Chemo Benefits Patients After Nephroureterectomy in UTUC

FRIDAY, Jan. 6, 2017 (HealthDay News) -- For patients undergoing radical nephroureterectomy (RNU) for pT3/T4 and/or pN+ upper tract urothelial carcinoma (UTUC), adjuvant chemotherapy (AC) use is associated with an overall survival benefit, according to a study published online Jan. 3 in the Journal of Clinical Oncology.

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Laparoscopy Can Prevent Futile Primary Cytoreductive Surgery

THURSDAY, Jan. 5, 2017 (HealthDay News) -- Diagnostic laparoscopy reduces the number of futile laparotomies in women with suspected advanced-stage ovarian cancer, according to a study published online Dec. 28 in the Journal of Clinical Oncology.

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Cancer Mortality Rates Continue to Decline in the United States

THURSDAY, Jan. 5, 2017 (HealthDay News) -- Cancer mortality rates in the United States have dropped 25 percent since the early 1990s, according to a new report published online Jan. 5 in CA: A Cancer Journal for Clinicians.

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Artificial Larynx Implant Feasible After Total Laryngectomy

THURSDAY, Jan. 5, 2017 (HealthDay News) -- An artificial larynx has provided long-term relief for a throat cancer patient in France who had a total laryngectomy, according to a letter to the editor published in the Jan. 5 issue of the New England Journal of Medicine.

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2000 to 2011 Saw Shift in Treatment for Advanced NSCLC

THURSDAY, Jan. 5, 2017 (HealthDay News) -- From 2000 to 2011 there were shifts in the treatment of advanced-stage non-small-cell lung cancer (NSCLC), with modest survival gains, according to a study published online Jan. 3 in the Journal of Clinical Oncology.

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Interface Between Allergy, Oncology Explored

WEDNESDAY, Jan. 4, 2017 (HealthDay News) -- The interface between allergic responses and oncology is being explored, which may have implications for treatment, according to a European Academy of Allergy and Clinical Immunology position paper published online Dec. 29 in Allergy.

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Cancer Cachexia Associated With Poor Outcomes

WEDNESDAY, Jan. 4, 2017 (HealthDay News) -- Patients with sustained or newly developed cancer cachexia at six and 12 months after initial treatment for advanced head and neck squamous cell carcinoma (HNSCC) are at higher risk of cancer recurrences, the onset of non-cancer health events, and poor survival outcomes, according to a study published online Dec. 21 in Head & Neck.

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Zoledronic Acid Every 12 Weeks Noninferior in Bone Metastases

TUESDAY, Jan. 3, 2017 (HealthDay News) -- Use of zoledronic acid every 12 weeks does not result in increased risk of skeletal events compared with use every four weeks among patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma, according to a study published in the Jan. 3 issue of the Journal of the American Medical Association.

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More Cognitive Difficulties for Patients After Chemotherapy

TUESDAY, Jan. 3, 2016 (HealthDay News) -- Compared with non-cancer controls, patients with breast cancer treated with chemotherapy have more cognitive difficulties up to six months after treatment, according to a study published online Dec. 28 in the Journal of Clinical Oncology.

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