January 2017 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for January 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Diabetes Mellitus Prevalence Higher in HIV-Infected Adults

TUESDAY, Jan. 31, 2017 (HealthDay News) -- HIV-infected adults have diabetes mellitus (DM) prevalence of 10.3 percent, which is higher than general population adults, according to a study published in the January issue of BMJ Open Diabetes Research & Care.

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Cardiovascular Event Risks May Be Affected by Timing of Meals

TUESDAY, Jan. 31, 2017 (HealthDay News) -- A new statement from the American Heart Association (AHA), published online Jan. 30 in Circulation, highlights what's known -- and what's not -- about meal timing and cardiovascular health.

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Smoking Imposes Heavy Burden on Global Economy

TUESDAY, Jan. 31, 2017 (HealthDay News) -- Nearly 6 percent of the world's health care spending is tied to smoking, according to research published online Jan. 30 in Tobacco Control.

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Guidelines Developed for Use of Growth Hormone in Children

TUESDAY, Jan. 31, 2017 (HealthDay News) -- Use of growth hormone (GH) in children and adolescents should be considered carefully, with assessment of the risks and benefits necessary for each patient, according to guidelines published in the January issue of Hormone Research in Paediatrics.

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Insulin Glargine 300 U/mL Beats Glargine 100 U/mL in T1DM

TUESDAY, Jan. 31, 2017 (HealthDay News) -- For patients with type 1 diabetes, receipt of insulin glargine 300 U/mL (Gla-300) is associated with better glucose control than glargine 100 U/mL (Gla-100), regardless of injection time, according to a study published online Jan. 23 in Diabetes Care.

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Hypoglycemia Induces Pro-Inflammatory Functional Changes

MONDAY, Jan. 30, 2017 (HealthDay News) -- Hypoglycemia can promote mobilization of specific subsets of leukocytes and induce pro-inflammatory functional changes in immune cells, according to a study published online Jan. 23 in Diabetes.

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Inconsistency Noted in Ocular Symptom Reporting

MONDAY, Jan. 30, 2017 (HealthDay News) -- Patient self-report of symptoms on an Eye Symptom Questionnaire (ESQ) is frequently inconsistent with documentation in the electronic medical record (EMR), according to a study published online Jan. 26 in JAMA Ophthalmology.

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Prediabetes Linked to Sedentary Lifestyle, Even in Slim Adults

FRIDAY, Jan. 27, 2017 (HealthDay News) -- Inactivity is associated with greater risk of prediabetes and diabetes, even for healthy-weight adults, according to a study published online Jan. 19 in the American Journal of Preventive Medicine.

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Economic Benefit for Combo Statin/TG-Specific Tx in T2DM

FRIDAY, Jan. 27, 2017 (HealthDay News) -- For patients with type 2 diabetes mellitus, there is a substantial economic benefit to treatment with statin-triglyceride (TG)-specific combination lipid therapy compared with monotherapy or no lipid pharmacotherapy, according to a study published in the Feb. 1 issue of The American Journal of Cardiology.

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Ketone Monitoring Infrequent in Patients With Type 1 Diabetes

FRIDAY, Jan. 27, 2017 (HealthDay News) -- For patients with type 1 diabetes (T1D), self-reported ketone monitoring is infrequent overall, according to research published online Jan. 18 in Diabetes Care.

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Aromatase Inhibitor + Growth Hormone Can Optimize Height

FRIDAY, Jan. 27, 2017 (HealthDay News) -- Use of an aromatase inhibitor in combination with growth hormone seems effective for optimizing height in 11β-hydroxylase-deficient congenital adrenal hyperplasia (CAH), according to a case report published online Jan. 26 in Pediatrics.

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Risk of Diabetes Down With HCV SVR in HIV/HCV Coinfection

FRIDAY, Jan. 27, 2017 (HealthDay News) -- In patients co-infected with HIV and hepatitis C virus (HCV), eradication of HCV is associated with a reduction in the risk of diabetes mellitus, according to a study published online Jan. 21 in Hepatology.

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Study Questions Tx of Subclinical Hypothyroidism in Pregnancy

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Treatment of subclinical hypothyroidism in pregnancy may not always be the best option, according to a study published online Jan. 25 in The BMJ.

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28% of Adults, 9% of Teens Use Tobacco Products in U.S.

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Despite the dangers, many American adults and teens still use tobacco products, according to a report published in the Jan. 26 issue of the New England Journal of Medicine.

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Most U.S. Children Consume at Least One Sugary Drink a Day

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Nearly two-thirds of boys and girls ages 2 to 19 in the United States drink at least one sugar-sweetened beverage daily, according to a January data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Most PCPs Oppose Complete Repeal of the Affordable Care Act

THURSDAY, Jan. 26, 2017 (HealthDay News) -- A majority of primary care doctors oppose full repeal of the Affordable Care Act, according to a perspective piece published online Jan. 25 in the New England Journal of Medicine.

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Serum Trypsinogen Levels Down in Type 1 Diabetes

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Patients with type 1 diabetes have significantly lower serum trypsinogen levels than those without type 1 diabetes, according to a study published online Jan. 23 in Diabetes Care.

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Strategies Presented for Addressing Uncompensated Time

THURSDAY, Jan. 26, 2017 (HealthDay News) -- Strategies can be employed to help physicians deal with the increasing burden of uncompensated tasks, according to an article published in Medical Economics.

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Continuous Glucose Monitoring Ups Control in T1DM Patients

WEDNESDAY, Jan. 25, 2017 (HealthDay News) -- A continuous glucose monitor (CGM) helps patients with type 1 diabetes better manage their blood glucose levels, according to two studies published in the Jan. 24/31 issue of the Journal of the American Medical Association.

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Diabetes Requiring Insulin Tied to Increased Stroke Risk in A-Fib

WEDNESDAY, Jan. 25, 2017 (HealthDay News) -- For patients with atrial fibrillation (AF), diabetes requiring insulin, but not diabetes without insulin treatment, is associated with an increased risk of stroke/systemic embolism, according to a study published in the Jan. 31 issue of the Journal of the American College of Cardiology.

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Diabetes Care Compromised for Hispanics With Limited English

TUESDAY, Jan. 24, 2017 (HealthDay News) -- Hispanic-American type 2 diabetes patients who lack proficiency in English are much less likely than non-Hispanic patients to take newly prescribed diabetes medications as directed, according to a study published online Jan. 23 in JAMA Internal Medicine.

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ACA Has Increased Coverage, Access for Chronically Ill Patients

TUESDAY, Jan. 24, 2017 (HealthDay News) -- Millions of Americans with a chronic illness gained health insurance coverage after the Affordable Care Act went into effect in 2010, according to a study published online Jan. 24 in the Annals of Internal Medicine.

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In T2DM, Bariatric Surgery Ups Splanchnic Vascular Responses

TUESDAY, Jan. 24, 2017 (HealthDay News) -- For obese patients with type 2 diabetes (T2D), bariatric surgery is associated with improved splanchnic vascular responses, according to a study published online Jan. 17 in Diabetes.

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Step Count Prescription Strategy Can Up Steps/Day

TUESDAY, Jan. 24, 2017 (HealthDay News) -- A physician-delivered step count prescription strategy with an individualized rate of increase can result in an increase in step count/day, according to a study published online Jan. 11 in Diabetes, Obesity and Metabolism.

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GDM Found to Increase Risk for Postpartum Depression

MONDAY, Jan. 23, 2017 (HealthDay News) -- Gestational diabetes mellitus (GDM) may increase a first-time mother's risk of postpartum depression, and a history of maternal depression along with GDM further increases that risk, according to a study published online Jan. 18 in Depression and Anxiety.

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Exenatide, Pioglitazone Effective for Poorly Controlled T2DM

MONDAY, Jan. 23, 2017 (HealthDay News) -- For patients with long-standing poorly controlled type 2 diabetes mellitus (T2DM) on metformin plus a sulfonylurea, combination therapy with exenatide and pioglitazone is effective and safe, according to a study published online Jan. 17 in Diabetes Care.

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QI Initiative Cuts Health Care Use in Children With Epilepsy

MONDAY, Jan. 23, 2017 (HealthDay News) -- A quality improvement (QI) initiative can reduce emergency department and health care utilization for children with epilepsy, according to a report published online Jan. 20 in Pediatrics.

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Obesity Underrepresented in Medical Licensing Exams

FRIDAY, Jan. 20, 2017 (HealthDay News) -- The most important concepts of obesity prevention and treatment are not adequately represented on the U.S. Medical Licensing Examination (USMLE) Step examinations, according to a study published recently in Teaching and Learning in Medicine.

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Type 1 Diabetes Tied to Gut Inflammation, Microbiota

FRIDAY, Jan. 20, 2017 (HealthDay News) -- Patients with type 1 diabetes exhibit inflammation in the digestive tract and gut bacteria in a pattern that differs from individuals who do not have diabetes or those who have celiac disease, according to a study published online Jan. 19 in the Journal of Clinical Endocrinology & Metabolism.

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Iatrogenic Cushing's Syndrome Described in 9-Year-Old Girl

FRIDAY, Jan. 20, 2017 (HealthDay News) -- In a case report published online Jan. 19 in Pediatrics, iatrogenic Cushing's syndrome (CS) is described in a 9-year-old girl who received topical ocular glucocorticoid (GC) treatment for bilateral iridocyclitis.

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Overall Survival Poor in Unresected Anaplastic Thyroid CA

FRIDAY, Jan. 20, 2017 (HealthDay News) -- For patients with unresected anaplastic thyroid carcinoma (ATC), overall survival (OS) is poor, but radiation therapy (RT) dose is associated with improved survival, according to a study published online Dec. 27 in Cancer.

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Hydrolyzed Cow's Milk Formula May Up Islet Autoimmunity

FRIDAY, Jan. 20, 2017 (HealthDay News) -- Use of hydrolyzed cow's milk-based formula introduced during the first seven days is associated with increased risk of islet autoimmunity in infants at increased risk of type 1 diabetes (T1D), according to a study published online Jan. 17 in Diabetes Care.

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Less Sitting Time Can Be Initial Step in Total Fitness Plan

THURSDAY, Jan. 19, 2017 (HealthDay News) -- The reduction and interruption of sitting time can be an initial step in the development of a total physical activity plan for male patients, according to the conclusions of a report published in the December issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Biomarkers, Clinical Risk Improve Prediction of Renal Function

THURSDAY, Jan. 19, 2017 (HealthDay News) -- For patients with type 2 diabetes and chronic kidney disease (CKD), a set of nine molecular biomarkers together with clinical risk factors enhances prediction of renal function loss, according to a study published online Jan. 11 in Diabetes Care.

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Oxytocin Ups Feeding, Social Skills in Infants With Prader-Willi

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- For infants with Prader-Willi syndrome (PWS), oxytocin (OXT) administration is associated with improvement in feeding and social skills, according to a study published online Jan. 18 in Pediatrics.

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Metabolites Linked to Renal Decline, Time to ESRD in T1DM

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- Serum levels of seven modified metabolites are associated with renal function decline and time to end-stage renal disease (ESRD) among patients with type 1 diabetes (T1D), according to a study published online Jan. 13 in Diabetes Care.

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Bariatric Sx May Help Prevent Incident Diabetic Retinopathy

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- There are fewer cases of incident diabetic retinopathy among obese patients with type 2 diabetes undergoing bariatric surgery compared with medical treatment, according to a review and meta-analysis published online Jan. 13 in Obesity Reviews.

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Neurodevelopment at Age 2 Not Worse After ART Conception

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- Cognitive, motor, and language development at age 2 years is similar for children born after assisted reproductive technologies (ART) conception and natural conception, according to a study published in the February issue of Obstetrics & Gynecology.

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Physician Excess Charges Create Financial Burden for Patients

TUESDAY, Jan. 17, 2017 (HealthDay News) -- Many doctors bill their private-paying patients two, three, even six times more than what Medicare pays for the same services, according to a research letter published in the Jan. 17 issue of the Journal of the American Medical Association.

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Normal Vitamin D Intake Not Linked to Kidney Stone Risk

TUESDAY, Jan. 17, 2017 (HealthDay News) -- There is no statistically significant correlation between typical vitamin D intake and incident kidney stones, according to a study published in the February issue of The Journal of Urology.

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Glyburide, Metformin Have Similar Effect in Gestational DM

TUESDAY, Jan. 17, 2017 (HealthDay News) -- For patients with gestational diabetes mellitus (GDM), glyburide and metformin are comparable in terms of glucose control and safety, according to a study published online Jan. 11 in Diabetes Care.

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Mortality Risk in T2DM Increased With Depression and/or Anxiety

MONDAY, Jan. 16, 2017 (HealthDay News) -- For individuals with type 2 diabetes, anxiety symptoms affect mortality risk, independently of depression symptoms, and attenuate the excess mortality associated with depression, according to a study published online Jan. 11 in Diabetes Care.

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Harmonized Normal Range of Testosterone Established

MONDAY, Jan. 16, 2017 (HealthDay News) -- In non-obese European and American men, aged 19 to 39 years, the harmonized normal range of testosterone is 264 to 916 ng/dL (2.5th to 97.5th percentile), according to a study published online Jan. 10 in the Journal of Clinical Endocrinology & Metabolism.

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Artificial Sweetener Use Up in U.S. Children in Recent Years

FRIDAY, Jan. 13, 2017 (HealthDay News) -- Consumption of foods and beverages with low-calorie sweeteners (LCS) such as aspartame, sucralose, and saccharin rose 200 percent among children between 1999 and 2012, while their use rose 54 percent among adults, according to a study published online Jan. 10 in the Journal of the Academy of Nutrition and Dietetics.

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More Education Needed for Clinicians on Transgender Health

FRIDAY, Jan. 13, 2017 (HealthDay News) -- More education relating to transgender health is needed for endocrinologists, according to research published online Jan. 10 in the Journal of Clinical Endocrinology & Metabolism.

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Tobacco Counseling for Youth, Adults Cuts Smoking Prevalence

FRIDAY, Jan. 13, 2017 (HealthDay News) -- Tobacco counseling for youth or adults can reduce the prevalence of smoking cigarettes during adult years, according to a study published in the January/February issue of the Annals of Family Medicine.

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177Lu-Dotatate Ups PFS in Midgut Neuroendocrine Tumors

THURSDAY, Jan. 12, 2017 (HealthDay News) -- For patients with advanced midgut neuroendocrine tumors, lutetium-177 (177Lu)-Dotatate is associated with longer progression-free survival than high-dose octreotide long-acting repeatable (LAR), according to a study published in the Jan. 12 issue of the New England Journal of Medicine.

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Sitagliptin Has Neutral CV Risk Effect in Elderly With T2DM, CVD

THURSDAY, Jan. 12, 2017 (HealthDay News) -- Sitagliptin has a neutral effect on cardiovascular risk among older patients with type 2 diabetes, according to a study published online Jan. 5 in Diabetes Care.

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Low Serum Vitamin D Linked to Frequent Headache in Men

THURSDAY, Jan. 12, 2017 (HealthDay News) -- Low serum 25-hydroxyvitamin D (25[OH]D) is associated with frequent headache in middle-aged and older men, according to a study published online Jan. 3 in Scientific Reports.

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No Cognitive Benefit for Long-Term Lifestyle Intervention

THURSDAY, Jan. 12, 2017 (HealthDay News) -- For overweight and obese adults with diabetes mellitus, a long-term intensive lifestyle intervention does not offer cognitive benefits, according to a study published online Jan. 9 in the Journal of the American Geriatrics Society.

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Excessive FDA Regulation Driving High Drug Prices

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- The excessive regulatory regime at the U.S. Food and Drug Administration is an important driver of high drug prices, and should be curbed to introduce more competition and lower prices, according to a report published online Jan. 5 by the National Center for Policy Analysis.

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Parathyroid Hormone Linked to Arterial Stiffness in T1DM

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- In individuals with type 1 diabetes, parathyroid hormone (PTH) is associated with arterial stiffness, even after adjustment for multiple confounding variables, according to research published online Jan. 6 in Diabetes Care.

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CDC: Renal Failure From Diabetes Declining in Native Americans

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- Diabetes-related end-stage renal disease among Native American adults fell by more than half over almost 20 years, according to research published in the Jan. 10 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Many Families Find High Health Care Deductibles Burdensome

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- High-deductible health plans have multiplied in recent years, and they may pose a significant financial burden on Americans with chronic conditions, according to two studies published online Jan. 9 in JAMA Internal Medicine.

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Tobacco Control Plays Key Role in Saving Both Lives and Dollars

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- Smoking kills about six million people a year, and costs the world more than $1 trillion a year in health care expenses and lost productivity, but billions of dollars and millions of lives could be saved through higher tobacco prices and taxes, according to a report from the World Health Organization and the U.S. National Cancer Institute.

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Enteroviruses May Be Linked to Autoimmunity Leading to T1DM

TUESDAY, Jan. 10, 2017 (HealthDay News) -- Enteroviruses may play a role in the development of at least some cases of type 1 diabetes, according to a study published online Jan. 9 in Diabetologia.

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Mathematical Model Can Simulate HbA1c Progression in T2DM

TUESDAY, Jan. 10, 2017 (HealthDay News) -- A mathematical model (MM) can simulate hemoglobin A1c (HbA1c) trajectories in type 2 diabetes mellitus (T2DM) models, according to a study published online Dec. 27 in Diabetes, Obesity and Metabolism.

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Diabetes May Impair Myocardial Proangiogenic Response

MONDAY, Jan. 9, 2017 (HealthDay News) -- The amplitude of therapeutic revascularization associated with recombinant adeno-associated virus (rAAV) (5 × 1012 viral particles encoding thymosin beta 4 [Tβ4]) is reduced with diabetes mellitus, according to an experimental study published in the Jan. 17 issue of the Journal of the American College of Cardiology.

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Adipose Tissue Insulin Resistance Up in Obese-NGT, IGT, T2DM

MONDAY, Jan. 9, 2017 (HealthDay News) -- Resistance to the antilipolytic effect of insulin (Adipo-IR) is increased in obese individuals with normal glucose tolerance (NGT), and in those with impaired glucose tolerance (IGT) and type 2 diabetes (T2DM), according to a study published online Jan. 4 in Diabetes.

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Very Obese Teens Benefit From Gastric Bypass Over Long Term

FRIDAY, Jan. 6, 2017 (HealthDay News) -- Weight-loss surgery helps severely obese teens maintain weight loss over the long term; however, some young people may need additional surgery to manage complications associated with their rapid post-surgery weight loss, and some may also develop nutritional deficiencies, according to two studies published online Jan. 5 in The Lancet Diabetes & Endocrinology.

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GlycA Linked to Insulin Sensitivity, Independent of CRP

FRIDAY, Jan. 6, 2017 (HealthDay News) -- N-acetylglucosamine/galactosamine (GlycA) is associated with insulin sensitivity, independent of C-reactive protein (CRP), according to a study published online Dec. 28 in Diabetes Care.

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Diabetes Linked to Increased Incidence of Conjunctivitis

FRIDAY, Jan. 6, 2017 (HealthDay News) -- Diabetes is associated with increased incidence of conjunctivitis, according to a study published online Dec. 29 in Diabetes Care.

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Meta-Analysis Links Omega-3 Fatty Acid Consumption to T2DM

THURSDAY, Jan. 5, 2017 (HealthDay News) -- Consumption of single omega-3 is associated with an increased risk of type 2 diabetes (T2D), with dosage, ethnicity, trial duration, and recruited age influencing the effect, according to a meta-analysis published online Dec. 29 in the Journal of Diabetes Investigation.

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Some Apolipoproteins Linked to Incident Type 2 Diabetes

THURSDAY, Jan. 5, 2017 (HealthDay News) -- Apolipoprotein (apo) CIII and apoCIII-to-apoA1 ratio are correlated with incident type 2 diabetes (T2D), according to a study published online Dec. 28 in Diabetes Care.

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DASH Tops the 2017 Rankings for Best Diets

WEDNESDAY, Jan. 4, 2017 (HealthDay News) -- For the seventh year in a row, U.S. News & World Report has named the Dietary Approaches to Stop Hypertension (DASH) dietary plan as the best choice of diet overall, followed by the Mediterranean diet, up from fourth place last year.

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Fenofibrate May Reduce CVD in Patients With DM, Dyslipidemia

WEDNESDAY, Jan. 4, 2017 (HealthDay News) -- Fenofibrate therapy may reduce cardiovascular disease (CVD) in statin-treated patients with diabetes and dyslipidemia, according to a study published online Dec. 28 in JAMA Cardiology.

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Metformin Tied to Better Clinical Outcomes in CKD, CHF, CLD

WEDNESDAY, Jan. 4, 2017 (HealthDay News) -- For patients with chronic kidney disease (CKD), congestive heart failure (CHF), or chronic liver disease (CLD) with hepatic impairment, metformin use is associated with improvements in clinical outcomes, according to a review published online Jan. 3 in the Annals of Internal Medicine.

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Sequential Empagliflozin, Linagliptin Diabetes Tx Effective

WEDNESDAY, Jan. 4, 2017 (HealthDay News) -- After metformin failure, sequential treatment escalation with empagliflozin and linagliptin is an effective diabetes treatment option due to additive effects on postprandial glucose control, according to a study published online Dec. 23 in Diabetes, Obesity and Metabolism.

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Sex Hormone-Sensitive Gene Complex Implicated in PMDD

TUESDAY, Jan. 3, 2017 (HealthDay News) -- The activity of certain genes are associated with premenstrual dysphoric disorder (PMDD), according to a study published online Jan. 3 in Molecular Psychiatry.

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ACP Updates Recommendations for Oral Medications in T2DM

TUESDAY, Jan. 3, 2017 (HealthDay News) -- The American College of Physicians (ACP) has updated recommendations on the oral pharmacologic treatment of type 2 diabetes in adults. The clinical practice guideline update was published online Jan. 3 in the Annals of Internal Medicine.

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