Ixekizumab Efficacious for Psoriasis Over 60 Weeks

This article originally appeared here.
Share this content:
Ixekizumab Efficacious for Psoriasis Over 60 Weeks
Ixekizumab Efficacious for Psoriasis Over 60 Weeks

THURSDAY, June 9, 2016 (HealthDay News) -- The benefits of ixekizumab in the treatment of psoriasis extend to 60 weeks, according to a study published online June 8 in the New England Journal of Medicine.

The findings are based on 3,866 patients who took part in three trials. In one trial, ixekizumab was tested against a placebo; in the other two, it was tested against a placebo and etanercept for the first 12 weeks, and then just placebo from then on. After the initial 12-week period, patients took the drug either once a month or every 12 weeks.

The researchers found that almost three-quarters of patients in the once-a-month group had minimal psoriasis, based on doctors' ratings. That compared with 7 percent of placebo patients. About four out of five patients who took the drug monthly had at least a 75 percent improvement in their skin symptoms. In the initial 12-week study, ixekizumab also outperformed etanercept by a significant margin. The researchers reported adverse events, including neutropenia, candidal infections, and inflammatory bowel disease, with ixekizumab use.

"As with any treatment, the benefits need to be weighed against the risks of adverse events," the authors write. "The efficacy and safety of ixekizumab beyond 60 weeks of treatment are not yet known."

The study was funded by Eli Lilly, the manufacturer of ixekizumab.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves Dupixent to Treat Eczema

FDA Approves Dupixent to Treat Eczema

Active ingredient binds to protein (interleukin-4 receptor alpha subunit) that causes inflammation

Arm, Hand Function Restored in Tetraplegic Patient

Arm, Hand Function Restored in Tetraplegic Patient

Researchers utilized functional electric stimulation + intracortical brain-computer interface system

Total Knee Replacement Typically Has Minimal Impact on QoL

Total Knee Replacement Typically Has Minimal Impact on ...

Cost-effectiveness of the procedure could increase if restricted to more severely affected patients

is free, fast, and customized just for you!

Already a member?

Sign In Now »