ISG15 Deficiency Linked to Antiviral Immunity in Humans

Share this content:
ISG15 Deficiency Linked to Antiviral Immunity in Humans
ISG15 Deficiency Linked to Antiviral Immunity in Humans

FRIDAY, May 27, 2016 (HealthDay News) -- Investigators describe a strategy for development of a broad-spectrum anti-viral agent. Their research was published online May 19 in Nature Communications.

Noting that studies in mice have demonstrated a role for Isg15 in antiviral immunity and that human ISG15 has been shown to have critical immune functions, Dusan Bogunovic, Ph.D., assistant professor of microbiology and pediatrics at the Icahn School of Medicine at Mount Sinai, and colleagues examined ISG15 deficiency in humans.

The researchers described ISG15-deficient patients who did not exhibit enhanced susceptibility to viruses in vivo; this was in contrast to Isg15-deficient mice. Enhanced antiviral protection was seen in fibroblasts derived from ISG15-deficient patients; ISG15 expression was found to reduce viral resistance to wild-type control levels.

"We believe a drug that turns off ISG15 in humans for a brief amount of time would help many people facing an emerging viral infection -- but of course, all this needs to be tested," Bogunovic said in a journal news release. He added that his team is now screening millions of small molecules to find a pill that can provide such an antiviral boost.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

USPSTF Urges BP Screening for Pre-eclampsia During Pregnancy

Grade B recommendation suggests substantial net benefit for screening for pre-eclampsia

Evidence Suggests Sodium Guidelines Are Misguided

Evidence Suggests Sodium Guidelines Are Misguided

Dietary sodium intake inversely associated with systolic, diastolic blood pressure in long term

Waiting 10 Months for Colonoscopy May Raise CRC Risk

Waiting 10 Months for Colonoscopy May Raise CRC ...

After positive FIT result, colonoscopy at 10 months also tied to more advanced disease

is free, fast, and customized just for you!

Already a member?

Sign In Now »