Intraoperative Methadone Cuts Post-Op Opioid Use in Spine Sx

Share this content:
Intraoperative Methadone Cuts Post-Op Opioid Use in Spine Sx
Intraoperative Methadone Cuts Post-Op Opioid Use in Spine Sx

MONDAY, May 1, 2017 (HealthDay News) -- For patients undergoing posterior spinal fusion surgery, intraoperative methadone administration is associated with reduced postoperative opioid requirements, according to a study published in the May issue of Anesthesiology.

Glenn S. Murphy, M.D., from the University of Chicago Pritzker School of Medicine in Evanston, Illinois, and colleagues conducted a parallel-group randomized trial to examine the effect of methadone on postoperative analgesic requirements, pain scores, and patient satisfaction after complex spine surgery. One hundred twenty patients undergoing posterior spinal fusion surgery were randomly allocated to receive methadone 0.2 mg/kg at the start of surgery or hydromorphone 2 mg at surgical closure.

Data were analyzed for 115 patients. The researchers found that median hydromorphone use was reduced in the methadone group on postoperative days one (4.56 versus 9.9 mg), two (0.6 versus 3.15 mg), and three (0 versus 0.4 mg). At 21 of 27 assessments, the methadone group had lower pain scores at rest, with movement, and with coughing. The methadone group had higher overall satisfaction with pain management until the morning of postoperative day three compared with the hydromorphone group.

"Intraoperative methadone administration reduced postoperative opioid requirements, decreased pain scores, and improved patient satisfaction with pain management," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »